Results 161 to 170 of about 124,441 (260)

New Developments in Phospholipase D [PDF]

Journal of Biological Chemistry, 1997
openaire   +2 more sources

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

British Journal of Pharmacology, EarlyView.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito, Sridhar Vasudevan, Shaun Hurley, Gary Gilmour, Frederick Westhorpe, Grant Churchill, Trevor Sharp   +6 more
wiley   +1 more source

N-aldehyde-modified phosphatidylethanolamines generated by lipid peroxidation are robust substrates of N-acyl phosphatidylethanolamine phospholipase D. [PDF]

J Lipid Res
Fadaei R, Bernstein AC, Jenkins AN, Pickens AG, Zarrow JE, Alli-Oluwafuyi AM, Tallman KA, Davies SS.   +7 more
europepmc   +1 more source

Study on the mechanism of efficient extracellular expression of toxic streptomyces phospholipase D in Brevibacillus choshinensis under Mg²⁺ stress. [PDF]

Microb Cell Fact, 2022
Chen S, Xiong W, Zhao X, Luo W, Yan X, Lu Y, Chen C, Ling X.   +7 more
europepmc   +1 more source

Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?

British Journal of Pharmacology, EarlyView.
Psychedelic drugs that activate 5‐HT2A receptors have been long used for cultural, medicinal and recreational purposes. Interest in psychedelics for treating psychiatric disorders has resurged recently and is well documented; less well recognised are their anti‐inflammatory properties. Growing evidence now demonstrates that psychedelics modulate immune
Omar Qureshi, Jamie Cowley, Ashley Pegg, Alison J. Cooper, John Gordon, Catherine A. Brady, Antonio Belli, Sam Butterworth, Rachel Upthegrove, Nick Andrews, Nicholas M. Barnes   +10 more
wiley   +1 more source

Predictive analysis of B-cell antigenic epitopes in phospholipase D toxins from <i>Loxosceles</i> spiders. [PDF]

Toxicon X
Catalán A, García C, Sambra V, Cadena N, Rojas J, Arán-Sekul T, San Francisco J, Vásquez-Saez V, Muñoz C, Vásquez A, Araya JE.   +10 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Structural and Energetic Evidence Supports the Non-Covalent Phosphate Cyclization by the Class II Phospholipase D from Loxosceles intermedia. [PDF]

Toxins (Basel)
Gismene C, Ruggiero Bachega JF, Doherty DZ, Veiga SS, Arni RK, Hernández González JE.   +5 more
europepmc   +1 more source

Genome-Wide Analysis and Expression Profiling of the Phospholipase D Gene Family in Solanum tuberosum. [PDF]

Biology (Basel), 2021
Li L, Zhang C, Zhang M, Yang C, Bao Y, Wang D, Chen Q, Chen Y.   +7 more
europepmc   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source