Results 61 to 70 of about 200,907 (241)
Growth Hormone Promotes Lipolysis and Impairs Insulin Sensitivity by Activating the ERK/HSL Signaling Pathway in Bovine Adipocytes
Animal Research and One Health, EarlyView.This study was to evaluate the role of GH in lipolysis and insulin sensitivity in bovine adipocytes and clarify the underlying mechanism. Our findings demonstrate that GH activates ERK/HSL signaling pathway, promotes lipolysis, and impairs insulin sensitivity in bovine adipocytes.Xinxing Gao, Hao Yu, Erminio Trevisi, Cai Lin, Zhiyuan Fang, Xinwei Li, Yuxiang Song, Wenwen Gao, Lin Lei, Xiliang Du, Guowen Liu +10 morewiley +1 more sourceFresh insights into the light‐induced pineal gland circadian rhythm transmission mechanism derived from mRNA and miRNA profiling
Animal Research and One Health, EarlyView.Mechanisms of light in regulating the chick pineal clock. Abstract
The circadian clock significantly impacts animal health and productivity, with light playing a crucial role in regulating circadian rhythms. However, the mechanisms behind light‐induced circadian transmission remain unclear, particularly in light‐sensitive avian species.Yunlei Li, Yanyan Sun, Jingwei Yuan, Xiangchen Li, Lei Shi, Adamu Mani Isa, Yuanmei Wang, Pingzhuang Ge, Yunhe Zong, Panlin Wang, Jilan Chen +10 morewiley +1 more sourceNegative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells. [PDF]
, 2017 The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and invasion.De Lorenzi, Valentina, Jalink, Kees, Kedziora, Katarzyna M., Leyton-Puig, Daniela, Matas-Rico, Elisa, Moolenaar, Wouter H., Perrakis, Anastassis, Sidenius, Nicolai, Stijf-Bultsma, Yvette, van de Wetering, Koen, van den Broek, Bram, van Veen, Michiel +11 morecore +3 more sourcesOptimizing biophysical properties of cellular niches to enhance stem cell‐derived extracellular vesicle function in musculoskeletal regeneration
BMEMat, EarlyView.Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...Yang Xu, Chung Yin Matthew Cheung, Liling Liu, Hoi Pan Harry Cheung, Kam Yu Tam, Dai Fei Elmer Ker, Sarah H. Cartmell, Chuanbin Mao, Zhiyong Zhang, Dan Michelle Wang +9 morewiley +1 more sourceOn the interactions of lipids and proteins in the red blood cell membrane [PDF]
, 1970 The effects of temperature and of the action of a purified phospholipase C enzyme preparation on human red blood cell membranes has been investigated by chemical analyses, circular dichroism, and proton magnetic resonance measurements.Chan, Sunney I., Glaser, Michael, Sheetz, Michael, Simpkins, Henry, Singer, S. J. +4 morecore Implications for oxidative stress and astrocytes following 26S proteasomal depletion in mouse forebrain neurones [PDF]
, 2013 Neurodegenerative diseases are characterized by progressive degeneration of selective neurones in the nervous system, but the underlying mechanisms involved in neuroprotection and neurodegeneration remain unclear.Abisambra, Ambruso, Andersen, Antunes, Aslihan Ugun-Klusek, Beal, Bedford, Beranova-Giorgianni, Bhandary, Chandra, Chatterjee, Choy, Croisier, Demasi, Dennissen, Ding, Dumitru Constantin-Teodosiu, Ebrahimi-Fakhari, Ellen Billett, Erdelmeier, Federico, Ferreiro, Fisher, Fisher, Fisher, Fisher, Freeman, Fribley, Gandhi, Goemaere, Goldberg, Grune, Hussong, Jain, Jamal Elkharaz, James Lowe, Jin, Jourdain, Kalyanaraman, Kamphuis, Karen Lawler, Kastle, Kim, Krapfenbauer, Leavey, Leuner, Lien, Ling, Lowe, Lynn Bedford, Malhotra, Manevich, Manevich, Mayford, Middeldorp, Morawe, Omura, Orre, Paine, Palacino, Pekny, Pickering, Pickering, Pimentel, Power, Power, Pratico, R John Mayer, Rabilloud, Samali, Schapira, Shringarpure, Slater, Sofroniew, Sofroniew, Strey, Tannu, Tsien, Varcin, Wang, Wang, Wang, Wang, Wang, Wang, Xiong, Yata, Zhang, Zoltewicz +88 morecore +1 more sourceUse of LC‐MS to characterize host cell protein removal during depth filtration
Biotechnology Progress, EarlyView.Abstract
The removal of host cell proteins (HCPs) is crucial in biopharmaceutical production, as residual impurities can impact product safety and efficacy. While a number of studies have demonstrated that depth filtration can provide significant HCP removal, there is little information on its effectiveness in removing specific HCPs.Liang‐Kai Chu, Ehsan Espah Borujeni, Xuankuo Xu, Andrew L. Zydney +3 morewiley +1 more sourceVarespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial [PDF]
, 2014 IMPORTANCE: Secretory phospholipase A2(sPLA2) generates bioactive phospholipid products implicated in atherosclerosis. The sPLA2inhibitor varespladib has favorable effects on lipid and inflammatory markers; however, its effect on cardiovascular outcomes ...Abraham, J, Abramson, B, Acheatel, R, Ahmed, M, Akhunova, S, Alegret, JM, Alonso-Pulpón, L, Amerena, J, Amkieh, A, Amlani, M, Anand, D, Anderson, J, Antolin, JM, Areses, EL, Arkhipov, M, Aroney, C, Arstall, M, Asfour, A, Ashchi, M, Auguadro, C, Azar, R, Balog, C, Banker, D, Barbarash, O, Barbarich, V, Bash, Dianna, Battaglia, J, Belenky, D, Benczur, B, BERNI, Andrea, Berti, S, Bertolet, B, Biasucci, LM, Black, R, Blanchard, A, Blonder, R, Bokern, MJ, Bosschaert, M, Braun-Dullaeus, R, Breedveld, RW, Brennan, Danielle M., Brilakis, E, Broadwater, S, Bronisz, M, Bronzwaer, PN, Brown, A, Brown, WV, Browne, K, Burtt, D, Camp, A, Cannon, K, Cavender, JB, Cavender, Matthew A., Cendon, AA, Cervinka, P, Chandna, H, Chandra, S, Chandrashekhar, Y, Chapidze, G, Chawla, K, Chernick, R, Chronos, N, Chumburidze, V, Collins, N, Constance, C, Corrada, E, Cortés, JM, Crowley, S, Csapo, K, Cuccia, C, Dabrowski, M, Dani, S, Dart, A, Davies, C, Delafontaine, P, Della-Siega, A, DeMets, D, Den Hartog, F, den Hartoog, M, Dengler, T, Denning, S, Derlaga, B, Devlin, G, Dezsi, C, Dinnyes, J, Dobrzycki, S, Doevendans, P, Dorsel, T, Dovgalevskiy, Y, Downes, T, Drenning, D, Drozdz, J, Drzewiecki, A, East, C, Eaton, G, Edes, I, Eich, D, Elliott, J, Ermoshkina, L, Esquivias, GB, Farshid, A, Faynyk, A, Fedele, F, Fernández, JD, Ferrier, L, Feskov, O, Fineschi, M, Franco, SN, French, W, Frey, N, Fulwani, M, Gebel, J, Genth-Zotz, S, Genís, AB, Gessek, J, Gielen, S, Gillespie, E, Gniot, J, Go, B, Goloborodko, B, Goloshchekin, B, González, MJ, Gordeev, I, Gormaz, CL, Gosselin, G, Goswami, R, Goya, IL, Gunalingam, B, Gupta, S, Guseva, G, Haldis, T, Haltern, G, Harding, S, Hart, H, Heckman, MJ, Hengstenberg, C, Henry, P, Hermans, W, Herrman, J, Heuer, H, Horak, D, Horowitz, J, Hubacek, J, Huff, C, Hulinsky, V, Hutyra, M, Huynh, T, Ilmer, B, Ingelmo, JM, Janik, M, Jarne, EF, Jay, D, Jukema, J. Wouter, Kahali, D, Kancz, S, Karpenko, O, Karpenko, Y, Kashou, H, Kastelein, John J. P., Katerenchuk, O, Katzan, I, Kedhi, E, Keijzers, M, Khaisheva, L, Khintibidze, I, Kie, SH, Kiss, R, Kleiman, N, Klein, G, Klimovic, T, Klimsa, Z, Kmetzo, J, Kobulia, B, Kochmanski, M, Koenig, W, Koenig, Wolfgang, Kokis, A, Kopytsya, M, Korban, E, Kornacewicz-Jach, Z, Kostenko, V, Kovacs, Z, Koval, O, Kozhukhov, S, Kozlowski, A, Kraiz, I, Kreuzer, J, Kukuy, E, Kuznetsov, V, Lago, VN, Lai, C, Lamas, G, Lambert, C, Lapp, H, Lauer, M, Lavi, S, Leithäuser, B, Lenderink, T, Leschke, M, Libis, R, Lieberman, S, Liem, A, Lincoff, A. Michael, Linev, K, Lioy, E, Lochridge, S, Lok, D, Loussararian, A, Lu, D, Lupkovics, G, MacDonald, L, Madej, A, Magagnini, E, Mahar, L, Maly, M, Mamatsashvili, M, Mann, J, Marenzi, G, Markov, V, Marso, S, Martin Mde, M, Martin, IH, Martin, L, Mayer, O, McCullum, K, Megreladze, I, Mennuni, M, Menon, Venu, Merenda, R, Merkely, B, Miekus, P, Mikhin, V, Minisi, A, Miranda, JM, Monhart, Z, Monraats, P, Montero, JS, Moretti, L, Motovska, Z, Movahed, M, Mudra, H, Mukherjee, A, Muller, G, Musial, W, Möllmann, H, Nagy, A, Nambi, Vijay, Nava, JS, Navarro, MJ, Nicholls, Stephen J., Nierop, P, Nissen,, Nogai, K, Oei, F, Ortiz, AI, Ovcharenko, E, Paradis, JM, Parikh, K, Parker, J, Peñaranda, AS, Pfeffer, M, Piscione, F, Pleva, L, Pluta, W, Polasek, P, Polgar, P, Polk, D, Pollock, S, Ponikowski, P, Prasad, C, Prati, F, Premchand, R, Prokhorov, O, Psuja, P, Pudil, R, Pérez, MB, Rajput, R, Ramaswamy, G, Rassi, A, Reichert, P, Rekosz, J, Rezkalla, S, Richardson, J, Rivera, E, Robertson, R, Rodes-Cabau, J, Roleau, J, Romero, AJ, Romo, AI, Ronaszeki, A, Ronner, E, Rosenberg, M, Rosenson, Robert S., Rotterova, H, Rubio, AM, Ruda, M, Rudenko, L, Runquist, L, Rynkiewicz, A, Sangiorgi, G, Sanmartín, M, Sanz, M, Sanz, RR, Saucedo, J, Schwartz, G, Schwartz, Gregory G., Seigel, P, Semenka, J, Senaratne, M, Sereg, M, Shaburishvili, T, Shah, A, Shalnev, V, Shishehbor, M, Shvarts, Y, Silverman, P, Simanenkov, V, Simonyi, G, Skelding, K, Soriano, FR, Speciale, G, Spinar, J, Stellbrink, C, Steven E., Hennekens C, Stillabower, M, Strain, J, Strasser, R, Sultan, P, Suriano, P, Tans, JG, Testa, R, Thadani, U, Thompson, P, Timofeev, A, Tolerico, P., Treasure, C, Trip, MD, Trivedi, S, Troquay, R, Uchino, K, Ujda, M, Urbano, RH, Vadaganelli, P, Vakaliuk, I, Valgimigli, M, van de Wetering, ML, van der Heijden, R, van Gaal, W, van Wijk, L, Veen, G, Vertes, A, Vest, A, Vijay, N, Vishnevsky, A, Voehringer, HF, Volkova, E, Wachter, R, Werner, N, White, M, Wiley, M, Wilkins, G, Williams, J, Witkowski, A, Wright, R. Scott, Wysokinski, A, Youssef, G, Zadra, R, Zateyshchikov, D, Zishiri, E, Zubiri, JJ +369 morecore +1 more sourceSAAP‐148 Oligomerizes into a Hexamer Forming a Hydrophobic Inner Core
ChemBioChem, EarlyView.The highly cationic and hydrophobic antimicrobial peptide SAP‐148 effectively eradicates multidrug‐resistant bacteria, persistent cells, and biofilms without inducing resistance. Its efficiency is likely due to its ability to disrupt bacterial membranes as an oligomer, forming a stable alpha‐helical hexameric bundle with three parallel dimers that ...Aden Hodzic, Djenana Vejzovic, Altea Topciu, Kirill Kuhlmann, Raj Kumar, Maria Andrea Mroginski, Alejandra de Miguel, Pia Hofmann, Klaus Zangger, Markus Weingarth, Robert A. Cordfunke, Jan W. Drijfhout, Peter Nibbering, Michal Belicka, Karl Lohner, Nermina Malanovic +15 morewiley +1 more source
