Results 121 to 130 of about 144,128 (376)
Frontiers in Microbiology, 2010 Many pathogenic microbes, including many fungi, produce phospholipases which facilitate survival of the pathogen in vivo, invasion and dissemination throughout the host, expression of virulence traits and evasion of host immune defense mechanisms.
Julianne eDjordjevic
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The substrate specificity of phospholipase A
Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects, 1963 Investigations on variously modified analogues of phospholipids elucidated the following substrate characteristics for phospholipase A (Crotalus adamanteus). 1. 1. Within the class of α-phosphoglycerides l-isomers are readily hydrolysed, while d-α-phospholipids appeared not to be attacked. 2. 2.
Deenen, L.L.M. van, Haas, Gerard H. de
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Phospholipase Cβ2 Binds to and Inhibits Phospholipase Cδ1 [PDF]
Journal of Biological Chemistry, 2005 Phospholipase Cβ (PLCβ) isoforms, which are under the control of Gαq and Gβγ subunits, generate Ca2+ signals induced by a broad array of extracellular agonists, whereas PLCδ isoforms depend on a rise in cytosolic Ca2+ for their activation. Here we find that PLCβ2 binds strongly to PLCδ1 and inhibits its catalytic activity in vitro and in living cells ...
Mario J. Rebecchi +2 more
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Advanced Science, EarlyView.ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li +5 more
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Insulin Action on Polyunsaturated Phosphatidic Acid Formation in Rat Brain: An “In Vitro” Model with Synaptic Endings from Cerebral Cortex and Hippocampus [PDF]
, 2009 The highly efficient formation of phosphatidic acid from exogenous 1-stearoyl-2-arachidonoyl-sn-glycerol (SAG) in rat brain synaptic nerve endings (synaptosomes) from cerebral cortex and hippocampus is reported.
Giusto, Norma Maria +2 more
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Phospholipase A2 as a mechanosensor
Biophysical Journal, 1995 Osmotic swelling of large unilamellar vesicles (LUVs) causes membrane stretching and thus reduces the lateral packing of lipids. This is demonstrated to modulate strongly the catalytic activity of phospholipase A2 (PLA2) toward a fluorescent phospholipid, 1-palmitoyl-2-[(6-pyren-1-yl)]decanoyl-sn-glycero-3-phosphocholine (PPDPC) residing in LUVs ...
Paavo K.J. Kinnunen +1 more
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Structural Basis of GABAB Receptor Activation during Evolution
Advanced Science, EarlyView.This study explores the structural and functional mechanisms of the drosophila GABAB receptor, a key role in neurotransmission. Using cryo‐EM, the research reveals how the receptor's activation differs from its human counterpart, highlighting unique evolutionary features.
Guofei Hou +14 more
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Lipase maturation factor 1 is required for endothelial lipase activity[S]
Journal of Lipid Research, 2011 Lipase maturation factor 1 (Lmf1) is an endoplasmic reticulum (ER) membrane protein involved in the posttranslational folding and/or assembly of lipoprotein lipase (LPL) and hepatic lipase (HL) into active enzymes.
Osnat Ben-Zeev +9 more
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Effective antiprotease-antibiotic treatment of experimental anthrax [PDF]
, 2005 BACKGROUND: Inhalation anthrax is characterized by a systemic spread of the challenge agent, Bacillus anthracis. It causes severe damage, including multiple hemorrhagic lesions, to host tissues and organs.
Alibek, Ken +8 more
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Phospholipase A Activity in the Epidermis
Journal of Investigative Dermatology, 1972 Phospholipase A activity has been demonstrated in cow snout epidermis. The activity was higher in the upper layers of the epidermis. The enzyme has been purified by preparing aqueous extracts of acetone powders obtained from epidermal homogenates. The most active preparation gave a pH optimum of 8.3 for the release of free fatty acids from phosphatidyl
V.J.W. Long, H.J. Yardley
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