Results 151 to 160 of about 144,128 (376)

Novel 4,5‐Dihydrothiazole‐Phenylpiperazine Derivatives: Synthesis, Docking Studies and Pharmacological Evaluation as Serotonergic Agents

ChemMedChem, EarlyView.
The synthesis of a new series of 4,5‐dihydrothiazol‐2‐ylphenylpiperazine derivatives as serotoninergic ligands is described and tested for their affinity toward 5‐HT1A, 5‐HT2A,and 5‐HT2C and selected for further in vivo assays to determine their functional activity. The pharmacological studies highlight that among the developed derivatives, FG‐7 and FG‐
Giorgia Andreozzi, Natalia Karkoszka, Rosa Sparaco, Angela Corvino, Beatrice Severino, Vincenzo Santagada, Elisa Magli, Ewa Gibuła‐Tarłowska, Jolanta H. Kotlińska, Kinga Gawel, Raffaele Capasso, Anna Lesniak, Nataliia Semenko, Agnieszka A. Kaczor, Anna Bielenica, Grażyna Biała, Giuseppe Caliendo, Ewa Kędzierska, Ferdinando Fiorino   +18 more
wiley   +1 more source

The Nutritional and Bioactive Components, Potential Health Function and Comprehensive Utilization of Hawthorn: A Review

Food Frontiers, EarlyView.
This review systematically and comprehensively analyzes hawthorn (Crataegus spp.), covering its bioactive constituents, properties, and processed products. ABSTRACT Hawthorn is widely cultivated in China, with excellent varieties and steadily increasing production.
Wenteng Yang, Quanhong Gao, Kun Ran, Mingyue Jiao, Xiaodan Fu, Zhenlin Han, Chao Liu, Ningyang Li   +7 more
wiley   +1 more source

Surface loops of extracellular phospholipase A1 determine both substrate specificity and preference for lysophospholipids

Journal of Lipid Research, 2012
Members of the pancreatic lipase family exhibit both lipase activity toward triacylglycerol and/or phospholipase A1 (PLA1) activity toward certain phospholipids.
Naoaki Arima, Asuka Inoue, Kumiko Makide, Takamasa Nonaka, Junken Aoki   +4 more
doaj  

The purification and properties of phospholipase A from human pancreas [PDF]

, 1962
Wendy L. Magee, Jennifer J. Gallai-Hatchard, H Sanders, RHS THOMPSON   +3 more
openalex   +1 more source

Molecular evolution of MAX effectors in the rice blast fungus Pyricularia oryzae [PDF]

, 2015
Fungal plant pathogens secrete proteins, termed “effectors”, that enable them to interact with their hosts and to influence the outcome of the interaction.
Charriat, F., Cros-Arteil, Sandrine, Fournier, Elisabeth, Gladieux, Pierre, Gracy, Jérôme, Kroj, Thomas, Ravel, Sébastien   +6 more
core  

Comparative Analysis of Differential Metabolites in Panax quinquefolius From China and the United States Using UPLC‐Orbitrap‐MS and LC‐MS/MS

Food Safety and Health, EarlyView.
trans‐ferulic acid and sinapic acid could be used to distinguish Chinese ginseng from American ginseng. Panax quinquefolius from China and the United States produced unique metabolites and phenolic compounds. ABSTRACT Currently, there is a relative paucity of comparative studies on the metabolites of American ginseng from different geographical sources.
Dan Li, Ling Xie, Fan Li, Haoran Li, Zhipeng Zhang, Yi Peng, Liang Gong   +6 more
wiley   +1 more source

Identification of plasma proteins binding oxidized phospholipids using pull-down proteomics and OxLDL masking assay‡

Journal of Lipid Research
Oxidized phospholipids (OxPLs) are increasingly recognized as toxic and proinflammatory mediators, which raises interest in the mechanisms of their detoxification.
Philipp Jokesch, Lisa Holzer, Lydia Jantscher, Sebastian Guttzeit, Rudolf Übelhart, Olga Oskolkova, Valery Bochkov, Bernd Gesslbauer   +7 more
doaj  

HISTAMINE RELEASE BY BEE VENOM PHOSPHOLIPASE A AND MELLITIN IN THE RAT [PDF]

, 1965
A. M. Rothschild
openalex   +1 more source

Adrenergic Control of P2Y6 Receptor‐Dependent Phagocytosis in Rodent and Human Microglia

Glia, EarlyView.
Adrenergic signaling through ADRB2 modulates phagocytosis in microglia. Crosstalk between ADRB2 and P2Y6 receptors conserved in rodent and human microglia. ADRB2 activation inhibits both P2Y6 function and gene expression. ABSTRACT Microglia, the resident immune cells of the central nervous system (CNS), are in constant survey of their environment ...
Thomas Deluc, Ariel Ase, Marie‐France Dorion, Gilles Maussion, Yeman Tang, Rita T. M. Lo, Irina Shlaifer, Valerio E. Piscopo, Thomas M. Durcan, Stefano Stifani, Philippe Séguéla   +10 more
wiley   +1 more source

Phospholipase D and phosphatidic acid in the biogenesis and cargo loading of extracellular vesicles

Journal of Lipid Research, 2018
Extracellular vesicles released by viable cells (exosomes and microvesicles) have emerged as important organelles supporting cell-cell communication.
Antonio Luis Egea-Jimenez, Pascale Zimmermann   +1 more
doaj