Results 151 to 160 of about 43,115 (285)

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Polyamine treatments: an effective strategy to improve crop yield and fruit colour and to preserve quality of ‘Mollar de Elche’ pomegranate fruit during storage at chilling temperatures

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Climate change in Spain is altering the optimal conditions for producing high‐quality ‘Mollar de Elche’ pomegranate fruit, due to reduced colour development in husk and arils. In addition, the pomegranate requires storage above 7–10 °C, depending on cultivar, to preserve its quality because it is susceptible to chilling injury (CI ...
Jenifer Puente‐Moreno, Fernando Garrido‐Auñón, María E García‐Pastor, Fabián Guillén, Salvador Castillo, Daniel Valero, María Serrano   +6 more
wiley   +1 more source

Cnidarian toxins: omics approaches and recombinant proteins. [PDF]

J Venom Anim Toxins Incl Trop Dis
Vega-Tamayo JE, Alcantar-Orozco EJ, Mendoza-Ramírez RA, Silva-Díaz LG, Aguilar-Salazar JA, Salvador-Aguilar DH, Rojas-Molina A.   +6 more
europepmc   +1 more source

Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) is a life‐threatening stroke subtype that lacks effective drug therapy. In the context of ICH, neuroinflammation, and ferroptosis are key contributors to secondary brain injury. In this study, we assessed the neuroprotective effects of matrine (MAT) and its mechanism of action involving the HMGB1/RAGE axis in an ...
Pan‐Di Chen, Tao‐Tao Shi, Dan‐Yang Hu, Xiao‐Na Su, Jian‐Xiang Jin, Mao‐Song Chen, Hao Wang, Wei Chen   +7 more
wiley   +1 more source

Phospholipases A₂ (PLA₂s) and Related Peptides from <i>Bothrops</i> Snake Venoms: History, Structure, Pharmacology, and Inhibitors. [PDF]

Biomolecules
Santos ICD, Romanazzi M, Malachias-Pires GM, Aragão AR, Filardi ETM, Melo-Dos-Santos G, Salvador LC, Cerveja MF, Rocha AM, Magalhães A, de Oliveira IS, Almeida JR, Santos-Filho NA, Pucca MB.   +13 more
europepmc   +1 more source

Exome Sequencing Identifies Variants in MLH1 and ERBB2 as Potential Cancer‐Predisposing Factors in Familial Early‐Onset Colorectal Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Colorectal cancer (CRC) has raised considerable health concerns worldwide, with increasing incidence rates, specifically among younger populations. Despite remarkable progress in diagnosing and treating various diseases, the genetic basis of CRC remains only partially understood.
Behnaz Bagheri, Neda Mohsen‐Pour, Najmeh Salehi, Pardis Ketabi Moghadam, Adel Zeinalpour, Amir Sadeghi, Samira Kalayinia, Nayeralsadat Fatemi   +7 more
wiley   +1 more source

Snake Venom PLA₂ as Anticoagulant Agents: Role of Crotoxin, from <i>Crotalus durissus</i> Rattlesnake, in Hemostasis. [PDF]

Toxins (Basel)
Brasileiro-Martins LM, Marques GD, Maciel JB, Neiva M, Nascimento TP, Reyes DJE, Feitosa AJC, Angiole-Cavalcante S, Aquino PF, Sachett JAG, Monteiro WM, Sartim MA.   +11 more
europepmc   +1 more source

Impact of CYP2C19 Genotype Variants on PCSK9 Inhibitor Efficacy in Lipid‐Lowering Among Patients With Symptomatic Intracranial Atherosclerotic Stenosis

Lipids, EarlyView.
ABSTRACT Ischemic stroke is frequently associated with symptomatic intracranial atherosclerotic stenosis (sICAS), is a leading cause of global disability and mortality. Current guidelines recommend dual antiplatelet and intensive statin therapies. Proprotein convertase subtilisin 9/kexin type 9 (PCSK9) inhibitors have emerged as a potent lipid‐lowering
Chao Zhao, Nuan Wang, Di Shi, Hao Zhou, Dan Chen, Guofang Chen   +5 more
wiley   +1 more source

New Insights into the Bioenergetic and Immunomodulatory Properties of Phospholipases A₂ from <i>Bothrops diporus</i> Venom. [PDF]

Toxins (Basel)
Sasovsky DJ, Oliveira AK, Silva DT, Ojeda GA, Almarza C, Lomonte B, Fox JW, Urra FA, Bustillo S.   +8 more
europepmc   +1 more source