Results 61 to 70 of about 43,115 (285)

Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications [PDF]

, 2019
Since its discovery, the study of the biological role ofα-synuclein and its pathologicalimplications has been the subject of increasing interest. The propensity to adoptdifferent conformational states governing its aggregation and fibrillation makes ...
Alza, Natalia Paola, Conde, Melisa Ailén, Iglesias González, Pablo Andrés, Salvador, Gabriela Alejandra, Uranga, Romina Maria   +4 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Engineering the Rod of Asclepius – A Biochemical Investigation of Snake Venom Components and their Application as Potential Cancer Treatments [PDF]

, 2019
In the wild, venom is crucial to many snakes’ success as predators. While antivenin research focuses on combatting venoms’ abilities to disrupt physiological processes, new studies are attempting to manipulate these same abilities into anticancer ...
Pena, Noel
core   +1 more source

Redirection of lipid flux toward phospholipids in yeast increases fatty acid turnover and secretion [PDF]

, 2018
Bio-based production of fatty acids and fatty acid-derived products can enable sustainable substitution of petroleum-derived fuels and chemicals. However, developing new microbial cell factories for producing high levels of fatty acids requires extensive
Ferreira, Raphael, Nielsen, Jens, Siewers, Verena, Teixeiraa, Paulo Goncalves   +3 more
core   +1 more source

Characterization of Lysophospholipase D Activity in Mammalian Cell Membranes

Cells
Lysophosphatidic acid (LPA) is a lipid mediator that binds to G-protein-coupled receptors, eliciting a wide variety of responses in mammalian cells. Lyso-phospholipids generated via phospholipase A2 (PLA2) can be converted to LPA by a lysophospholipase D
Yuhuan Xie, Krishna M. Ella, Terra C. Gibbs, Marianne E. Yohannan, Stewart M. Knoepp, Pravita Balijepalli, G. Patrick Meier, Kathryn E. Meier   +7 more
doaj   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

The effect of experimental hyperoxia on erythrocytes’ oxygen-transport function [PDF]

, 2018
The aim of this study was to investigate the effect of hyperoxia, calcium ions and pH value on the composition of major phospholipids in human erythrocyte membranes and erythrocytes’ oxygen-transport function. To create a model of hyperoxia, we saturated
Alexander Alexandrovich Moskovkin, Alexander Yurievich Tychkov, Anastasia Nikolaevna Kukina, Anastasia Yurievna Samonova, Bligh EA, Borza C, Dobrotyna NA, Drgová A, Elvira Sergeevna Revina, Gavrilov VB, Gavrilov VB, Igor Pavlovich Grunyushkin, Jean-Christophe Bourdon, Litvitskiy PF, Marangoni AG, Marinetti GV, Morrison WR, Natalia Vasilevna Gromova, Nikolai Zhelev, Novitskiy VV, Sikorski AF, Takakuwa Y, Vasil'yeva YEM, Vercaеmst L, Victor Vasilevich Revin, Vlasov AP   +25 more
core   +4 more sources

Short Linear Motifs Characterizing Snake Venom and Mammalian Phospholipases A2

Toxins, 2021
Snake venom phospholipases A2 (PLA2s) have sequences and structures very similar to those of mammalian group I and II secretory PLA2s, but they possess many toxic properties, ranging from the inhibition of coagulation to the blockage of nerve ...
Caterina Peggion, Fiorella Tonello
doaj   +1 more source