Results 21 to 30 of about 22,642,428 (383)
mBio, 2023 For its replication within red blood cells, the malaria parasite depends on a highly active and regulated lipid metabolism. Enzymes involved in lipid metabolic processes such as phospholipases are, therefore, potential drug targets.
Paul-Christian Burda +12 more
doaj +1 more source
A neurotoxic phospholipase A2 impairs yeast amphiphysin activity and reduces endocytosis. [PDF]
PLoS ONE, 2012 BACKGROUND: Presynaptically neurotoxic phospholipases A(2) inhibit synaptic vesicle recycling through endocytosis. PRINCIPAL FINDINGS: Here we provide insight into the action of a presynaptically neurotoxic phospholipase A(2) ammodytoxin A (AtxA) on ...
Mojca Mattiazzi +9 more
doaj +1 more source
Substrate-Specific Inhibition Constants for Phospholipase A2 Acting on Unique Phospholipid Substrates in Mixed Micelles and Membranes Using Lipidomics. [PDF]
, 2019 Assaying lipolytic enzymes is extremely challenging because they act on water-insoluble lipid substrates, which are normally components of micelles, vesicles, and cellular membranes.
Armando, Aaron +2 more
core +6 more sources
Proceedings of the National Academy of Sciences of the United States of America, 1982 Nephrotoxicity is an important side effect of aminoglycoside antibiotics, which are used to control infections caused by Gram-negative bacteria. Accumulation of aminoglycosides and phospholipids in the lysosomes is a prominent and early feature of ...
K. Hostetler, L. B. Hall
semanticscholar +1 more source
A novel lipase with dual localisation in Trypanosoma brucei
Scientific Reports, 2022 Phospholipases are esterases involved in lipid catabolism. In pathogenic micro-organisms (bacteria, fungi, parasites) they often play a critical role in virulence and pathogenicity. A few phospholipases (PL) have been characterised so far at the gene and
S.G. Monic +7 more
doaj +1 more source
European Journal of Biochemistry, 2005 Two phospholipases A, CM-II and CM-III, were purified from the Siamese cobra (Naja naja kaouthia) venom, from Thailand, by gel filtration on Sephadex G-50 followed by ion-exchange chromatography on CM-cellulose. They each comprise 119 amino acid residues
Francois J. Joubert, N. Taljaard
semanticscholar +1 more source
Secreted Phospholipases A2 - not just Enzymes: Revisited
International Journal on Biological Sciences, 2022 Secreted phospholipases A2 (sPLA2s) participate in a very broad spectrum of biological processes through their enzymatic activity and as ligands for membrane and soluble receptors.
A. Ivanušec, J. Šribar, I. Križaj
semanticscholar +1 more source
Secretory Phospholipases A2 in Plants [PDF]
, 2019 Secreted phospholipases (sPLA2s) in plants are a growing group of enzymes that catalyze the hydrolysis of sn-2 glycerophospholipids to lysophospholipids and free fatty acids. Until today, around only 20 sPLA2s were reported from plants.
Fidelio, Gerardo Daniel +1 more
core +1 more source
Phospholipase A2 and Phospholipase B activities in fungi [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2006 As saprophytes or disease causing microorganisms, fungi acquire nutrients from dead organic material or living host organisms. Lipids as structural components of cell membranes and storage compartments play an important role as energy-rich food source.
Audrey Brenot +5 more
openaire +3 more sources
An amphitropic cAMP-binding protein in yeast mitochondria [PDF]
, 1989 : We describe the first example of a mitochondrial protein with a covalently attached phos-phatidylinositol moiety acting as a membrane anchor. The protein can be metabolically labeled with both stearic acid and inositol.
Bandlow W. +43 more
core +3 more sources