Results 31 to 40 of about 22,642,428 (383)

Role of Phospholipases in Fungal Fitness, Pathogenicity and Drug Development- Lessons from Cryptococcus neoformans

Frontiers in Microbiology, 2010
Many pathogenic microbes, including many fungi, produce phospholipases which facilitate survival of the pathogen in vivo, invasion and dissemination throughout the host, expression of virulence traits and evasion of host immune defense mechanisms.
Julianne eDjordjevic
doaj   +1 more source

Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase

FEBS Open Bio, 2021
Bacterial phospholipases and sphingomyelinases are lipolytic esterases that are structurally and evolutionarily heterogeneous. These enzymes play crucial roles as virulence factors in several human and animal infectious diseases.
Laura Monturiol-Gross, Fabián Villalta-Romero, M. Flores-Dı́az, A. Alape-Girón   +3 more
semanticscholar   +1 more source

PTEN regulates phospholipase D and phospholipase C [PDF]

Human Molecular Genetics, 2007
PTEN is an ubiquitously expressed tumor suppressor which plays a prominent role in the pathogenesis of many types of sporadic solid tumors, including breast cancer, as well as hematologic malignancies. Germline PTEN mutations cause 85% of Cowden syndrome (CS), characterized by a high risk of breast and thyroid cancers, and 65% of Bannayan-Riley ...
Charis Eng, Kristin A. Waite, Kristin A. Waite, Christopher Alvarez-Breckenridge   +3 more
openaire   +3 more sources

Cyclosporin A inhibits PGE2 release from vascular smooth muscle cells [PDF]

, 1987
The influence of the fungoid undecapeptide cyclosporin A (CyA) on PGE2 release from cultured rat aortic smooth muscle cells was investigated in this study.
Koch, K. M., Kurtz, Armin, Kühn, K., Pfeilschifter, J.   +3 more
core   +1 more source

The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming

Toxins, 2021
A global strategy, under the coordination of the World Health Organization, is being unfolded to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure safe and effective treatments.
José María Gutiérrez, Laura-Oana Albulescu, Rachel H. Clare, Nicholas R. Casewell, Tarek Mohamed Abd El-Aziz, Teresa Escalante, Alexandra Rucavado   +6 more
doaj   +1 more source

Comprehensive analysis of the circular RNA expression profile and circRNA–miRNA–mRNA network in the goat skin with divergent wool curvature

Animal Research and One Health, EarlyView., 2023
In our study, we conducted circRNA expression profiling of Zhongwei goat skin exhibiting divergent curvature wool phenotypes at two developmental stages using the RNA‐seq. Functional verification assay demonstrated that circRNA8782 regulated fibroblast proliferation.
Yingxiao Su, Zhanqiang Zhao, Zhanfa Liu, Xiaobo Li, Qian Chen, Yabin Pu, Lin Jiang, Xiaohong He, Yuehui Ma, Qianjun Zhao   +9 more
wiley   +1 more source

Polarization of macrophages toward M2 phenotype is favored by reduction in iPLA2β (group VIA phospholipase A2)* [PDF]

, 2016
Macrophages are important in innate and adaptive immunity. Macrophage participation in inflammation or tissue repair is directed by various extracellular signals and mediated by multiple intracellular pathways.
Ashley, Jason W, Bone, Robert N, Hancock, William D, Nelson, Alexander J, Ramanadham, Sasanka, Tse, Hubert M, Turk, John, Wohltmann, Mary   +7 more
core   +2 more sources

Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine.

Proceedings of the National Academy of Sciences of the United States of America, 1986
Human platelets stimulated by epinephrine undergo enhanced turnover of phosphatidylinositol 4,5-bisphosphate, accumulate inositol trisphosphate, diacylglycerol, and phosphatidic acid, and phosphorylate a 47-kDa protein.
H. S. Banga, Elizabeth R. Simons, L. F. Brass, S. Rittenhouse   +3 more
semanticscholar   +1 more source

Identification of caspase 3 motifs and critical aspartate residues in human Phospholipase D1b and Phopsholipase D2a [PDF]

, 2008
Stimulation of mammalian cells frequently initiates phospholipase D-catalysed hydrolysis of phosphatidylcholine in the plasma membrane to yield phosphatidic acid (PA) a novel lipid messenger.
Ahn, Avila-Flores, Brown, Cazzolli, Chen, Cross, Degterev, Du, Earnshaw, Farquhar, Fisher, Graham Ladds, Guimaraes, Hodgkin, Hui, Iwasaki-Bessho, Kasai, Kusner, Lim, Matthew N. Hodgkin, McDermott, Michelle H. Wright, Michelle J. Farquhar, Mina-olga Aletrari, Nakashima, Nozawa, Oh, O’Luanaigh, Palicz, Park, Ponting, Powner, Powner, Rozengurt, Samejima, Shi, Timmer, Wissing, Xie, Yamada, Zeniou-Meyer, Zhao, Zheng, Zhong   +43 more
core   +1 more source

Candida albicans pathogenicity mechanisms [PDF]

, 2013
Peer reviewedPublisher ...
Alonso-Monge R, Braun BR, Csank C, De Bernardis F, Diez-Orejas R, Fonzi WA, Hube B, Hwang CS, Mühlschlegel FA, Sorger PK, Wysong DR   +10 more
core   +1 more source