Results 111 to 120 of about 498,126 (336)

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation [PDF]

, 2018
Sophie Lepropre, Shakeel Kautbally, Marie Octave, Audrey Ginion, Marie-Blanche Onselaer, Gregory R. Steinberg, Bruce E. Kemp, Alexandre Hego, Odile Wéra, Sanne L. N. Brouns, Frauke Swieringa, Martin Giera, Victor Darley‐Usmar, Jérôme Ambroise, Bruno Guigas, Johan W. M. Heemskerk, Luc Bertrand, Cécile Oury, Christophe Beauloye, Sandrine Horman   +19 more
openalex   +1 more source

Lower Incidence of Necrotizing Enterocolitis in Infants Fed a Preterm Formula with Egg Phospholipids [PDF]

, 1998
Susan E. Carlson, Michael B. Montalto, Debra Ponder, Susan H. Werkman, Sheldon B. Korones   +4 more
openalex   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix

eLife, 2015
Maintenance of energy homeostasis depends on the highly regulated storage and release of triacylglycerol primarily in adipose tissue, and excessive storage is a feature of common metabolic disorders.
David Barneda, Joan Planas-Iglesias, Maria L Gaspar, Dariush Mohammadyani, Sunil Prasannan, Dirk Dormann, Gil-Soo Han, Stephen A Jesch, George M Carman, Valerian Kagan, Malcolm G Parker, Nicholas T Ktistakis, Judith Klein-Seetharaman, Ann M Dixon, Susan A Henry, Mark Christian   +15 more
doaj   +1 more source

Ti6Al4V‐Bioglass‐Copper Composites for Load‐Bearing Implants

Advanced Healthcare Materials, EarlyView.
We have designed and manufactured a novel Ti64‐based composite by adding 45S5 bioglass (BG) and copper (Cu). Adding BG on titanium improves wear resistance and biocompatibility, whereas Cu addition improves mechanical strength while providing inherent lifelong bacterial resistance.
Lochan Upadhayay, Bryson White, Susmita Bose, Amit Bandyopadhyay   +3 more
wiley   +1 more source

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

eLife, 2015
The role of specific phospholipids (PLs) in lipid transport has been difficult to assess due to an inability to selectively manipulate membrane composition in vivo.
Xin Rong, Bo Wang, Merlow M Dunham, Per Niklas Hedde, Jinny S Wong, Enrico Gratton, Stephen G Young, David A Ford, Peter Tontonoz   +8 more
doaj   +1 more source

Injectable Stimuli‐Responsive Amphiphilic Hydrogel for Rapid Hemostasis, Robust Tissue Adhesion, and Controlled Drug Delivery in Trauma and Surgical Care

Advanced Healthcare Materials, EarlyView.
Fast‐acting hydrogel seals bleeding wounds as the illustrated injectable, pH‐responsive network rapidly gels in situ to stop hemorrhage, adhere strongly to wet tissue, and release antibiotics in a controlled, pH‐dependent manner. The material withstands high pressures, shows excellent biocompatibility, and degrades safely, offering a versatile platform
Arvind K. Singh Chandel, Runali Patil, Abrar Ali Khan, Deeksha Pandit, Kaushik Chatterjee, Maurice N. Collins   +5 more
wiley   +1 more source

Immunological Study of Aborted Women Infected with Toxoplasmosis in Basrah Province

Journal of Medical Sciences
Background Toxoplasmosis is regarded as one of the chief sources of miscarriage in pregnant women which caused by an apicomplexan obligatory intracellular parasites called Toxoplasma gondii.
Baydaa F. Swadi, Dawood Mahdi, Khalid Mezeal   +2 more
doaj   +1 more source