Results 101 to 110 of about 336,810 (311)

Extrusion Bioprinting for Wound Healing: Innovations in Functionalized Bioinks and Bioprinting Technology

Advanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting (EBB) has emerged as a versatile biofabrication platform capable of precisely depositing bioinks composed of biomaterials, cells, and bioactive agents to generate patient‐specific, biomimetic skin constructs. This paper presents a state‐of‐the‐art and forward‐looking overview of EBB for wound healing, encompassing printing ...
Hien‐Phuong Le, Anh Tuan Trong Tran, Ammara Waheed, Tran Thanh Tung, Dusan Losic   +4 more
wiley   +1 more source

Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6−/− mice

Journal of Lipid Research, 2008
Elucidation of the metabolic pathways of triacylglycerol (TAG) synthesis is critical to the understanding of chronic metabolic disorders such as obesity, cardiovascular disease, and diabetes.
Cynthia A. Nagle, Laurent Vergnes, Hendrik DeJong, Shuli Wang, Tal M. Lewin, Karen Reue, Rosalind A. Coleman   +6 more
doaj   +1 more source

Kaempferol-Phospholipid Complex: Formulation, and Evaluation of Improved Solubility, In Vivo Bioavailability, and Antioxidant Potential of Kaempferol [PDF]

, 2016
The current work describes the formulation and evaluation of a phospholipid complex of kaempferol to enhance the latter’s aqueous solubility, in vitro dissolution rate, in vivo antioxidant and hepatoprotective activities, and oral bioavailability.
Dave, Vivek S, Darshan R. Telange, Arun T. Patil, Telange, Darshan R., Amol A. Tatode, Fegade, Harshal, Pethe, Anil M., Tatode, Amol A., Anand, Sridhar, Patil, Arun T., Sridhar Anand, Anil M. Pethe, Vivek S. Dave   +12 more
core  

Phospholipid composition of the rat lens is independent of diet

, 2008
Dietary fatty acids are known to influence the phospholipid composition of many tissues in the body, with lipid turnover occurring rapidly. The aim of this study was to investigate whether changes in the fatty acid composition of the diet can affect the ...
Truscott, R. J. W., Nealon, J. R., Mitchell, T. W., Hulbert, A. J., Blanksby, Stephen J., Abbott, S. K.   +5 more
core   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis[S]

Journal of Lipid Research, 2010
Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step during de novo synthesis of glycerolipids. Mammals have at least four GPAT isoforms. Here we report the further characterization of the two recently identified microsomal GPAT3
Dandan Shan, Jian-liang Li, Leeying Wu, Dongmei Li, Jonathan Hurov, James F. Tobin, Ruth E. Gimeno, Jingsong Cao   +7 more
doaj   +1 more source

Cryptococcus flips its lid – membrane phospholipid asymmetry modulates antifungal drug resistance and virulence

, 2016
Human fungal infections are increasing in prevalence and acquisition of antifungal drug resistance, while our antifungal drug armamentarium remains very limited, constituting a significant public health problem. Despite the fact that prominent antifungal
David S. Perlin, Yina Wang, Erika Shor, Chaoyang Xue   +3 more
core   +1 more source

Influence of dietary phospholipid on early development and performance of Atlantic salmon (Salmo salar) [PDF]

, 2015
The present study aimed to confirm the requirement for dietary phospholipid in Atlantic salmon and better define the level and period of requirement. Thus, the effects of dietary supplementation with phospholipid supplied by krill or soy lecithin were ...
Tocher, Douglas R, Walton, James M., Tinch, Alan E, Migaud, Herve, Tocher, Douglas R., Taylor, John F., Taylor, John, Martinez-Rubio, Laura, Walton, Jamie, del Pozo, Jorge, Tinch, Alan E.   +10 more
core   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

Effect of cholesterol in suspension on the incorporation of phosphate into phospholipid by macrophages in vitro

Journal of Lipid Research, 1966
Macrophages obtained from the peritoneal cavity of rabbits were incubated with phosphate-32P in order to investigate the synthesis of phospholipid by these cells.
A.J. Day, N.H. Fidge, G.N. Wilkinson
doaj   +1 more source