Results 21 to 30 of about 300,277 (292)

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

eLife, 2015
The role of specific phospholipids (PLs) in lipid transport has been difficult to assess due to an inability to selectively manipulate membrane composition in vivo.
Xin Rong, Bo Wang, Merlow M Dunham, Per Niklas Hedde, Jinny S Wong, Enrico Gratton, Stephen G Young, David A Ford, Peter Tontonoz   +8 more
doaj   +1 more source

Identification of a lipid scrambling domain in ANO6/TMEM16F

eLife, 2015
Phospholipid scrambling (PLS) is a ubiquitous cellular mechanism involving the regulated bidirectional transport of phospholipids down their concentration gradient between membrane leaflets.
Kuai Yu, Jarred M Whitlock, Kyleen Lee, Eric A Ortlund, Yuan Yuan Cui, H Criss Hartzell   +5 more
doaj   +1 more source

Membrane-bound O-acyltransferase 7 (MBOAT7)-driven phosphatidylinositol remodeling in advanced liver disease

Journal of Lipid Research, 2022
Advanced liver diseases account for approximately 2 million deaths annually worldwide. Roughly, half of liver disease-associated deaths arise from complications of cirrhosis and the other half driven by viral hepatitis and hepatocellular carcinoma ...
Venkateshwari Varadharajan, William J. Massey, J. Mark Brown   +2 more
doaj   +1 more source

Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport

eLife, 2015
Polyunsaturated fatty acids (PUFAs) in phospholipids affect the physical properties of membranes, but it is unclear which biological processes are influenced by their regulation. For example, the functions of membrane arachidonate that are independent of
Tomomi Hashidate-Yoshida, Takeshi Harayama, Daisuke Hishikawa, Ryo Morimoto, Fumie Hamano, Suzumi M Tokuoka, Miki Eto, Miwa Tamura-Nakano, Rieko Yanobu-Takanashi, Yoshiko Mukumoto, Hiroshi Kiyonari, Tadashi Okamura, Yoshihiro Kita, Hideo Shindou, Takao Shimizu   +14 more
doaj   +1 more source

Effects of Cooling Rate and Emulsifier Combination on the Colloidal Stability of Crystalline Dispersions Stabilized by Phospholipids and β-Lactoglobulin

Colloids and Interfaces, 2023
A lot of applications for (semi-)crystalline triacylglycerol (TAG)-in-water dispersions exist in the life science and pharmaceutical industries.
Jasmin Reiner, Charlotte Schüler, Volker Gaukel, Heike Petra Karbstein   +3 more
doaj   +1 more source

Core aldehydes of alkyl glycerophosphocholines in atheroma induce platelet aggregation and inhibit endothelium-dependent arterial relaxation

Journal of Lipid Research, 2002
Plaque disruption with superimposed thrombosis is considered to be responsible for precipitating acute coronary syndrome. We identified sn-1-alkyl- and sn-1-acyl-type glycerophosphocholine (GroPCho) core aldehydes from human atheromas and demonstrated ...
Hiroshi Kamido, Hiroyuki Eguchi, Hisao Ikeda, Tsutomu Imaizumi, Kazunari Yamana, Karsten Hartvigsen, Amir Ravandi, Arnis Kuksis   +7 more
doaj   +1 more source

ATP11C mutation is responsible for the defect in phosphatidylserine uptake in UPS-1 cells

Journal of Lipid Research, 2015
Type IV P-type ATPases (P4-ATPases) translocate phospholipids from the exoplasmic to the cytoplasmic leaflets of cellular membranes. We and others previously showed that ATP11C, a member of the P4-ATPases, translocates phosphatidylserine (PS) at the ...
Naoto Takada, Hiroyuki Takatsu, Rie Miyano, Kazuhisa Nakayama, Hye-Won Shin   +4 more
doaj   +1 more source

Recent Advances in Intranasal Liposomes for Drug, Gene, and Vaccine Delivery

Pharmaceutics, 2023
Liposomes are safe, biocompatible, and biodegradable spherical nanosized vesicles produced from cholesterol and phospholipids. Recently, liposomes have been widely administered intranasally for systemic and brain delivery. From the nasal cavity, liposome-
Van-An Duong, Thi-Thao-Linh Nguyen, Han-Joo Maeng   +2 more
doaj   +1 more source

Novel subcellular localization for alpha-synuclein: possible functional consequences

Frontiers in Neuroanatomy, 2015
α−Synuclein (α-syn) is one of the genes that when mutated or overexpressed causes Parkinson’s Disease (PD). Initially, it was described as a synaptic terminal protein and later was found to be localized at mitochondria. Mitochondria-associated membranes (
Cristina eGuardia-Laguarta, Estela eArea-Gomez, Eric A Schon, Eric A Schon, Serge ePrzedborski   +4 more
doaj   +1 more source

The Phospholipid N-Methyltransferase and Phosphatidylcholine Synthase Pathways and the ChoXWV Choline Uptake System Involved in Phosphatidylcholine Synthesis Are Widely Conserved in Most, but Not All Brucella Species

Frontiers in Microbiology, 2021
The brucellae are facultative intracellular bacteria with a cell envelope rich in phosphatidylcholine (PC). PC is abundant in eukaryotes but rare in prokaryotes, and it has been proposed that Brucella uses PC to mimic eukaryotic-like features and avoid ...
Beatriz Aragón-Aranda, Leyre Palacios-Chaves, Miriam Salvador-Bescós, María Jesús de Miguel, María Jesús de Miguel, Pilar M. Muñoz, Pilar M. Muñoz, Miguel Ángel Vences-Guzmán, Amaia Zúñiga-Ripa, Leticia Lázaro-Antón, Christian Sohlenkamp, Ignacio Moriyón, Maite Iriarte, Raquel Conde-Álvarez   +13 more
doaj   +1 more source