Results 21 to 30 of about 225,303 (298)
eLife, 2015 The role of specific phospholipids (PLs) in lipid transport has been difficult to assess due to an inability to selectively manipulate membrane composition in vivo.
Xin Rong +8 more
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Identification of a lipid scrambling domain in ANO6/TMEM16F
eLife, 2015 Phospholipid scrambling (PLS) is a ubiquitous cellular mechanism involving the regulated bidirectional transport of phospholipids down their concentration gradient between membrane leaflets.
Kuai Yu +5 more
doaj +1 more source
Journal of Lipid Research, 2022 Advanced liver diseases account for approximately 2 million deaths annually worldwide. Roughly, half of liver disease-associated deaths arise from complications of cirrhosis and the other half driven by viral hepatitis and hepatocellular carcinoma ...
Venkateshwari Varadharajan +2 more
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Opsin Is a Phospholipid Flippase [PDF]
Current Biology, 2011 Polar lipids must flip-flop rapidly across biological membranes to sustain cellular life [1, 2], but flipping is energetically costly [3] and its intrinsic rate is low. To overcome this problem, cells have membrane proteins that function as lipid transporters (flippases) to accelerate flipping to a physiologically relevant rate.
Sakmar, TP +9 more
openaire +5 more sources
eLife, 2015 Polyunsaturated fatty acids (PUFAs) in phospholipids affect the physical properties of membranes, but it is unclear which biological processes are influenced by their regulation. For example, the functions of membrane arachidonate that are independent of
Tomomi Hashidate-Yoshida +14 more
doaj +1 more source
Colloids and Interfaces, 2023 A lot of applications for (semi-)crystalline triacylglycerol (TAG)-in-water dispersions exist in the life science and pharmaceutical industries.
Jasmin Reiner +3 more
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Journal of Lipid Research, 2002 Plaque disruption with superimposed thrombosis is considered to be responsible for precipitating acute coronary syndrome. We identified sn-1-alkyl- and sn-1-acyl-type glycerophosphocholine (GroPCho) core aldehydes from human atheromas and demonstrated ...
Hiroshi Kamido +7 more
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ATP11C mutation is responsible for the defect in phosphatidylserine uptake in UPS-1 cells
Journal of Lipid Research, 2015 Type IV P-type ATPases (P4-ATPases) translocate phospholipids from the exoplasmic to the cytoplasmic leaflets of cellular membranes. We and others previously showed that ATP11C, a member of the P4-ATPases, translocates phosphatidylserine (PS) at the ...
Naoto Takada +4 more
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Recent Advances in Intranasal Liposomes for Drug, Gene, and Vaccine Delivery
Pharmaceutics, 2023 Liposomes are safe, biocompatible, and biodegradable spherical nanosized vesicles produced from cholesterol and phospholipids. Recently, liposomes have been widely administered intranasally for systemic and brain delivery. From the nasal cavity, liposome-
Van-An Duong +2 more
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Novel subcellular localization for alpha-synuclein: possible functional consequences
Frontiers in Neuroanatomy, 2015 α−Synuclein (α-syn) is one of the genes that when mutated or overexpressed causes Parkinson’s Disease (PD). Initially, it was described as a synaptic terminal protein and later was found to be localized at mitochondria. Mitochondria-associated membranes (
Cristina eGuardia-Laguarta +4 more
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