Results 51 to 60 of about 300,277 (292)

Biomimetic lipid–fluorescein probe for cellular bioimaging

open access: yesFrontiers in Chemistry, 2023
Fluorescence probe is one of the most powerful tools for cellular imaging. Here, three phospholipid-mimicking fluorescent probes (FP1–FP3) comprising fluorescein and two lipophilic groups of saturated and/or unsaturated C18 fatty acids were synthesized ...
Hyungkyu Moon   +5 more
doaj   +1 more source

Plasma‐Treated Hydrogel for Combined RONS and Chemotherapy Delivery: A Proof‐of‐Concept In Ovo

open access: yesAdvanced Functional Materials, EarlyView.
This study explores plasma‐treated hydrogels (PTH) as a new way to deliver both reactive oxygen and nitrogen species and chemotherapy (Doxorubicin) directly to tumors. In ovo tests show effects after a single dose, especially in osteosarcoma tumors. Tumor weight decrease, and a resistance‐related protein is reduced.
Milica Živanić   +9 more
wiley   +1 more source

Kinetic dependence of phospholipase A2 activity on the detergent Triton X-100

open access: yesJournal of Lipid Research, 1973
A kinetic analysis is presented for the dependence of one form of phospholipase A2 from cobra (Naja naja) venom on the presence of the nonionic detergent Triton X-100 for its activity towards egg phosphatidylcholine and synthetic dipalmitoyl ...
Edward A. Dennis
doaj   +1 more source

A basic model for the association of ligands with membrane cholesterol: application to cytolysin binding

open access: yesJournal of Lipid Research, 2023
Almost all the cholesterol in cellular membranes is associated with phospholipids in simple stoichiometric complexes. This limits the binding of sterol ligands such as filipin and perfringolysin O (PFO) to a small fraction of the total. We offer a simple
Yvonne Lange   +2 more
doaj   +1 more source

Engineering Hybrid Extracellular Vesicles for Functional mRNA Delivery

open access: yesAdvanced Functional Materials, EarlyView.
This study optimizes two methods for the generation of extracellular vesicle (EV)‐mimetic‐Lipid Nanoparticle (LNP) (CELLNPs) and EV‐LNP (HEVs) hybrid nanoparticles for messenger (mRNA) delivery. The authors screen lipid compositions to maximize hybrid nanoparticle formation and analyze the resulting nanoparticles with single particle characterization ...
Ana Filipa Louro   +6 more
wiley   +1 more source

Structure and function of lysosomal phospholipase A2: identification of the catalytic triad and the role of cysteine residues

open access: yesJournal of Lipid Research, 2005
Lysosomal phospholipase A2 (LPLA2) is an acidic phospholipase that is highly expressed in alveolar macrophages and that may play a role in the catabolism of pulmonary surfactant.
Miki Hiraoka   +2 more
doaj   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

open access: yesAdvanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen   +30 more
wiley   +1 more source

Isolation and characterization of a phospholipase A2 from an inflammatory exudate

open access: yesJournal of Lipid Research, 1978
Sterile peritoneal exudates produced in rabbits injected with 1% glycogen contain a phospholipase A activity in a cell-free supernatant fraction that hydrolyzed a synthetic phospholipid (1,2-diacyl-sn-glycero-3-phospho-ethanolamine) and phospholipids of ...
R Franson, Dr   +4 more
doaj   +1 more source

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