Results 81 to 90 of about 498,126 (336)

Marked Long‐term Improvement in Lung Function in Melanoma Differentiation‐associated Protein 5 (MDA5) Antibody Positive Dermatomyositis Patients: Experience of a Single Center Longitudinal Cohort in North America

Arthritis Care &Research, Accepted Article.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation‐associated gene 5 antibody (MDA5 ab) associated dermatomyositis (DM). Methods Thirty patients with MDA5 ab DM were identified in a single center longitudinal cohort of 352 patients with ...
Jenice X Cheah, Sangmee S Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source

Fine structure of frozen-etched lipid granules in the fat body of an insect

Journal of Lipid Research, 1972
Lipid storage in fat-body cells of adult female black flies was examined using freeze-etching electron microscopy. Frozen-etched lipid granules exhibited a laminated structure.
T.P. Liu, D.M. Davies
doaj   +1 more source

The enhancement of the aqueous solubility of ritonavir via formulation of a drug-phospholipid complex [PDF]

, 2015
Objective: To evaluate the enhancement of aqueous solubility of a poorly water soluble drug ritonavir by forming its complex with a phospholipid (Phospholipon®90H)
Bernardez, M., Dave, Vivek S, Dhore, Pradip, Diware, R. G., Haware, Rahul V., Raut, Nishikant, Saoji, Suprit   +6 more
core   +1 more source

Thermodynamic Approach to Phase Coexistence in Ternary Phospholipi-Cholesterol Mixtures

, 2011
We introduce a simple and predictive model for determining the phase stability of ternary phospholipid-cholesterol mixtures. Assuming that competition between the liquid and gel order of the phospholipids is the main driving force behind lipid ...
Marques, Carlos M., Thalmann, Fabrice, Wolff, Jean   +2 more
core   +3 more sources

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Relationship between phospholipid transfer protein activity and HDL level and size among inbred mouse strains

Journal of Lipid Research, 1999
Because of the paucity of data on phospholipid transfer protein (PLTP) activity and lipoprotein phospholipid in mouse strains, plasma PLTP activity (PLTA), plasma phospholipid and cholesterol, HDL phospholipid and cholesterol, and HDL size distribution ...
John J. Albers, Wendy Pitman, Gertrud Wolfbauer, Marian C. Cheung, Hal Kennedy, An-Yue Tu, Santica M. Marcovina, Beverly Paigen   +7 more
doaj   +1 more source

Physical and chemical processes and the morphofunctional characteristics of human erythrocytes in hyperglycaemia [PDF]

, 2017
Background: This study examines the effect of graduated hyperglycaemia on the state and oxygen-binding ability of hemoglobin, the correlation of phospholipid fractions and their metabolites in the membrane, the activity of proteolytic enzymes and the ...
Bourdon, Jean Christophe, Gromova, Natalia V., Grunyushkin, Igor P., Klenova, Natalia A., Pestryakova, Anastasia A., Prosnikova, Ksenia V., Revin, Victor V., Revina, Elvira S., Sadykhova, Anna V., Solomadin, Ilia N., Tychkov, Alexander Y., Zhelev, Nikolai   +11 more
core   +5 more sources

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Substrate specificity of lipoprotein lipase and endothelial lipase: studies of lid chimeras

Journal of Lipid Research, 2006
The triglyceride (TG) lipase gene subfamily, consisting of LPL, HL, and endothelial lipase (EL), plays a central role in plasma lipoprotein metabolism. Compared with LPL and HL, EL is relatively more active as a phospholipase than as a TG lipase.
Nathalie Griffon, Elaine C. Budreck, Christopher J. Long, Uli C. Broedl, Dawn H.L. Marchadier, Jane M. Glick, Daniel J. Rader   +6 more
doaj   +1 more source

Souvenaid in the Management of Mild Cognitive Impairment: An Expert Consensus Opinion [PDF]

, 2019
Background Mild cognitive impairment (MCI) among an aging global population is a growing challenge for healthcare providers and payers. In many cases, MCI is an ominous portent for dementia.
Bertolucci, Paulo, Cappa, Stefano, Chen, Christopher, Chu, Leung-Wing, Cummings, Jeffrey, Engelborghs, Sebastiaan, Garcia-Ribas, Guillermo, Manzano, Sagrario, McGuinness, Bernadette, Mok, Vincent, Passmore, Peter, Woodward, Michael   +11 more
core   +3 more sources