Results 81 to 90 of about 300,277 (292)

3D Printing of Bacteriophage‐Loaded Hydrogels: Development of a Local and Long‐Lasting Delivery System

Advanced Healthcare Materials, EarlyView.
This research investigates the feasibility of 3D‐printing of a bacteriophage‐containing hydrogel made of alginate and methylcellulose. The printed hydrogels steadily release active bacteriophages for up to 35 days which is beneficial to treat implant‐associated infections.
Corina Vater, Gopala Krishna Mannala, Max von Witzleben, Richard Frank Richter, Nike Walter, Michael Gelinsky, Volker Alt, Anja Lode, Markus Rupp   +8 more
wiley   +1 more source

Methotrexate‐Loaded Liposomal Formulation Enables 6‐Week Sustained Intraocular Therapeutic Drug Release in a Porcine Model

Advanced Healthcare Materials, EarlyView.
A liposomal formulation for methotrexate enables minimally invasive, sustained intraocular drug delivery for over six weeks with a single injection. Developed for treating intraocular diseases like lymphoma and PVR, it offers excellent biocompatibility in vivo in a porcine model.
Maximilian Hammer, Lea Skrzypczyk, Sabrina Wohlfart, Bryan Calder Ackermann, Ludwig Geisweid, Simon William Pohl, Margarita Karaivanova, Jonathan Herth, Victor Aristide Augustin, Alexander Studier‐Fischer, Tina Sackmann, Leon Kaulen, Anna Steyer, Walter Mier, David H Steel, Kanmin Xue, Gerd Uwe Auffarth, Philipp Uhl   +17 more
wiley   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

INFLUENCE OF REFINING PROCESSES ON PHOSPHOLIPID CONTENT OF SUNFLOWER OIL

, 2023
Oybek Zufarov, Kamar Serkayev
openalex   +1 more source

Photosensitizing Lipid Nanoparticles for Ferroptosis‐Enhanced Photodynamic Cancer Therapy via GPX4 Silencing

Advanced Healthcare Materials, EarlyView.
Photosensitizing lipid nanoparticles (PLNPs) are engineered by incorporating cholesterol–PEG–pheophorbide a into MC3‐based LNPs and encapsulating GPX4‐targeting siRNA. Upon light activation, PLNPs generate reactive oxygen species (ROS) while silencing GPX4 to induce ferroptosis.
Ga‐Hyun Bae, Seungyong Shin, Joo Dong Park, Eun‐Young Koh, Seunghyo Ko, Jieun Han, Chun Gown Park, Dong‐Hyun Kim, Kun Na, Wooram Park   +9 more
wiley   +1 more source

Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate [PDF]

, 2017
Joanna J. Kaylor, Tongzhou Xu, Norianne T. Ingram, Avian Tsan, H.Ts. Hakobyan, Gordon Fain, Gabriel H. Travis   +6 more
openalex   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

Dendrimers Improve Apolipoprotein Nanoparticle mRNA Delivery to Immune Cells

Advanced Materials, EarlyView.
Apolipoprotein nanoparticle (aNP) platform technology efficiently delivers RNA to immune cells following systemic administration. Here, it is demonstrated that incorporating polyvalent ionizable cationic dendrimers in aNPs enables robust mRNA complexation and functional delivery.
Mirre M. Trines, Daniek Hoorn, Stijn R.J. Hofstraat, Robby C. Zwolsman, Tom Anbergen, Iris Versteeg, Yuri van Elsas, Jeroen Deckers, Merel M.A. Hendrikx, Teun Kleuskens, Youssef B. Darwish, Gijs W.B. Ros, Sjoerd F. Dijkstra, Bram Priem, Matt Timmers, P. Michel Fransen, Maarten J. Pouderoijen, Bas F.M. de Waal, E.W. Meijer, Thijs J. Beldman, Yohana C. Toner, Ewelina Kluza, Willem J.M. Mulder, Henk M. Janssen, Roy van der Meel   +24 more
wiley   +1 more source

Polyphenol‐Mediated Engineering of Lipid Nanoparticles With Crystalline Mesophases

Advanced Materials, EarlyView.
A polyphenol‐mediated strategy enables the one‐step formation of lipid nanoparticles with nonlamellar mesophases, including micellar cubic and hexagonal structures. These highly ordered nanostructures accommodate a wide range of cargos—from metal ions to mRNA—and offer a modular and versatile platform for constructing functional lipid‐based delivery ...
Shiyao Li, Patrick Charchar, Haitao Yu, Zhixing Lin, Hamish G. Brown, Wanjun Xu, Chan‐Jin Kim, Irene Yarovsky, Yi Ju, Frank Caruso   +9 more
wiley   +1 more source