Results 101 to 110 of about 329,041 (285)

Connexin channels and phospholipids: association and modulation

BMC Biology, 2009
Background For membrane proteins, lipids provide a structural framework and means to modulate function. Paired connexin hemichannels form the intercellular channels that compose gap junction plaques while unpaired hemichannels have regulated functions in
Harris Andrew L, Locke Darren
doaj   +1 more source

Cisplatin liposome and 6-amino nicotinamide combination to overcome drug resistance in ovarian cancer cells [PDF]

, 2018
Ovarian cancer is an aggressive and lethal cancer usually treated by cytoreductive surgery followed by chemotherapy. Unfortunately, after an initial response, many patients relapse owing mainly to the development of resistance against the standard ...
Catanzaro, Daniela, Cocetta, Veronica, Montopoli, Monica, Nicolosi, Silvia, Pagetta, Andrea, Pasut, Gianfranco, Ragazzi, Eugenio, Salvalaio, Marika   +7 more
core   +1 more source

Nanothermometry in Living Cells: Physical Limits, Conceptual and Material Challenges

Advanced Functional Materials, EarlyView.
Heat and temperature are fundamental to life. When nanothermometers began probing regions as small as a living cell, they triggered controversial claims of large intracellular temperature gradients. We review physical constraints energy‐conservation, entropy production, thermodynamic fluctuations, and molecular dynamics.
Taras Plakhotnik
wiley   +1 more source

The incorporation of dimethylaminoethanol and dimethylaminoisopropyl alcohol into Phormia regina phospholipids*

Journal of Lipid Research, 1963
The effect of replacing dietary choline with dimethylaminoethanol and dimethylaminoisopropyl alcohol on the larval phospholipids of the blowfly Phormia regina was investigated. It was found that these compounds were incorporated into the phospholipids to
Loran L. Bieber, R.W. Newburgh
doaj   +1 more source

Ion-channel-like behavior in lipid bilayer membranes at the melting transition

, 2010
It is well known that at the gel-liquid phase transition temperature a lipid bilayer membrane exhibits an increased ion permeability. We analyze the quantized currents in which the increased permeability presents itself. The open time histogram shows a "-
B. Hille, D. Colquhoun, J. B. Bassingthwaighte, J. C. Weaver, Jill Gallaher, Katarzyna Wodzińska, Martin Bier, T. Heimburg, Thomas Heimburg   +8 more
core   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

LL‐37 Driven Phase Transition and Stacking in Oligolamellar Gram‐Negative Bacterial Membrane Models

Advanced Functional Materials, EarlyView.
This work establishes oligolamellar bacterial membrane models to investigate how LL‐37 disrupts the complex dual‐bilayer architecture of Gram‐negative bacteria. Combining SAXS, cryo‐TEM, electrophoretic mobility measurements, and coarse‐grained simulations, it reveals cardiolipin‐driven phase transitions leading to bicelle‐like structures and membrane ...
Bettina Tran, Diane C.A. Lima, Linda Sandblad, Madeleine Ramstedt, Thereza A. Soares, Stefan Salentinig   +5 more
wiley   +1 more source

Phospholipid mediated activation of calcium dependent protein kinase 1 (CaCDPK1) from chickpea: a new paradigm of regulation.

PLoS ONE, 2012
Phospholipids, the major structural components of membranes, can also have functions in regulating signaling pathways in plants under biotic and abiotic stress.
Ajay Kumar Dixit, Chelliah Jayabaskaran
doaj   +1 more source

Biocompatible but Antibacterial Mechanism of Graphene Oxide for Sustainable Antibiotics

Advanced Functional Materials, EarlyView.
Graphene oxide (GO) exhibits selective antibacterial activity through specific interactions between its oxygen functional groups and bacterial membrane phospholipid POPG, causing membrane destabilization while maintaining biocompatibility. Model membrane studies and infected wound models in mice and pigs demonstrate effective bacterial suppression and ...
Sujin Cha, Ju Yeon Chung, Seungju Yang, Seung Cheol Lee, Chan Woo Lee, Colin Wing‐Lok Cheng, Jun Beom Kim, Nam Jun Kim, Ayoung Park, Heewon Choi, Junpyo Sinn, Ralph Weissleder, Nicholas A. Kotov, Myungeun Seo, Hyun Jung Chung, Sang Ouk Kim   +15 more
wiley   +1 more source

Lipid composition of hepatitis B virus surface antigen particles and the particle-producing human hepatoma cell lines.

Journal of Lipid Research, 1990
More than 90% of lipids of hepatitis B virus surface antigen (HBsAg) particles produced by two human hepatoma cell lines (huGK-14 and PLC/PRF/5) were composed of phospholipids, with phosphatidylcholine being the dominant component, accounting for more ...
O Satoh, M Umeda, H Imai, H Tunoo, K Inoue   +4 more
doaj   +1 more source