Results 211 to 220 of about 379,007 (338)

Phospholipid Interconversion and Transport Are Altered in Glaucoma. [PDF]

open access: yesFASEB J
Edwards G   +5 more
europepmc   +1 more source

A role for neutral sphingomyelinase activation in the inhibition of LPS action by phospholipid oxidation products [PDF]

open access: hybrid, 2006
Kimberly A. Walton   +6 more
openalex   +1 more source

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

open access: yesAdvanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan   +16 more
wiley   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

open access: yesAdvanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong   +15 more
wiley   +1 more source

96-Well Agarose-Gel Electromembrane Extraction. [PDF]

open access: yesAnal Chem
Samkumpim T   +6 more
europepmc   +1 more source

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