Results 221 to 230 of about 330,074 (303)

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Phospholipid-driven conformational switching of HCV NS5A links protein folding to replication membrane remodeling. [PDF]

Sci Adv
Bulankina AV, Richter RM, Nettles JH, Yamane D, Grimm C, Karami Y, Stanton RA, Introini B, Hermann J, Charif H, König MS, Stroß C, Ortiz C, Kraus N, Wood D, Galceran F, Abele R, Maigret B, Schinazi RF, Zeuzem S, Biondi RM, Yi M, Tampé R, Kudryashev M, Welsch C.   +24 more
europepmc   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

An siRNA targeting <i>S6k1</i> identifies photoreceptor phospholipid metabolism as a contributor to lipid buildup in age-related macular degeneration. [PDF]

Mol Ther Nucleic Acids
Cheng SY, Giguere D, Kim S, Seddon JM, Caiazzi J, Gross K, McHugh N, Echeverria D, Alterman JF, Gray-Edwards H, Benatti HR, Renner L, Woolard H, Stoddard J, McGill TJ, Neuringer M, Brush RS, Agbaga MP, Khvorova A, Punzo C.   +19 more
europepmc   +1 more source

Predominance of Ferroptotic Cell Death Mechanisms in Substantia Nigra Neurodegeneration in Parkinson's Disease

Annals of Neurology, EarlyView.
Objective The extent of neuronal loss in Parkinson's disease (PD) and the pathogenic processes underlying neuronal dysfunction and loss remain poorly understood. Here, we analyzed the expression of key molecules representing different cell death signaling pathways and their association with Lewy pathology, dopaminergic (DA) neuron loss and stage of PD ...
Yue Jing Heng, Anusha Jayaraman, Richard Reynolds, Jia Nee Foo   +3 more
wiley   +1 more source

Aggregation‐State Dynamics Drive Double Cooperativity Between Antimicrobial Peptides LL‐37 and HNP1

Angewandte Chemie, EarlyView.
The double cooperative effect between LL‐37 and HNP1 arises from dynamic changes in their aggregation state. These LL‐37/HNP1 assemblies reorganize in a target‐dependent manner, suppressing activity toward mammalian cells while enabling potent antibacterial action.
Yuge Hou, Jing Zhang, Koh Takeuchi, Hideo Higuchi, Motoshi Kaya, Rui Li, Jianlu Zheng, Jiali Chen, Go Watanabe, Kaori Sugihara   +9 more
wiley   +2 more sources

The role of lipids in neuromodulation for psychiatric disorders: A narrative review. [PDF]

Transl Psychiatry
Karaszewska DM, van Kesteren M, Bergfeld I, Lok A, Assies J, Dols A, van den Munckhof P, Schuurman R, Denys D, Mocking RJT.   +9 more
europepmc   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Melissa phospholipids improves sleep quality and mental well-being: concluding results from clinical study in adults with emotional distress. [PDF]

Food Nutr Res
Rondanelli M, Mazzola G, Barrile GC, Misiano P, Perna S.   +4 more
europepmc   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source