Results 61 to 70 of about 87,699 (269)

Phosphoprotein Profiling by PA-GeLC−MS/MS

, 2016
A significant consequence of protein phosphorylation is to alter protein−protein interactions, leading to dynamic regulation of the components of protein complexes that direct many core biological processes.
Stephen J. Kron (2108671), Kolbrun Kristjansdottir (2432182), David Sigfredo Angulo (2432179), Donald Wolfgeher (2432176), Nick Lucius (2432185)   +4 more
core   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Heterologous Caseins: The Role of Phosphorylation in Their Functionality and How to Achieve It

Biomolecules
Heterologous expression of caseins in non-mammalian systems offers a sustainable and scalable alternative for producing milk proteins, with potential applications in the food and biopharmaceutical industries.
Soledad Mora Vásquez, Santiago García-Jacobo, Guy A. Cardineau, Silverio García-Lara   +3 more
doaj   +1 more source

Phosphoprotein Profile of Ameloblastoma

Asian Pacific Journal of Cancer Prevention
Ameloblastoma (AM) is a well-known benign odontogenic tumor recognized for its aggressive nature, believed to originate from tooth-forming tissue or the dental follicle (DF). Phosphoproteins are crucial for cellular signaling, enabling intracellular communication and regulating various physiological processes. In cancer, phosphoproteins are fundamental
Sanguansin, Sirima, Kengkarn, Sudaporn, Klongnoi, Boworn, Topanurak, Supachai, Roytrakul, Sittirak, Chujan, Suthipong, Kitkumthorn, Nakarin   +6 more
openaire   +2 more sources

Conformation of the Phosphoprotein, Phosvitin

Journal of Biological Chemistry, 1970
Studies of viscosity, optical rotatory dispersion (ORD), and circular dichroism (CD) are reported on the phosphoprotein, phosvitin. From viscosity measurements it was shown that phosvitin in some of its properties resembles a polyelectrolyte. At low ionic strength the protein molecules, because of the strong electrostatic repulsion between the charged ...
K, Grizzuti, G E, Perlmann
openaire   +2 more sources

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Phosphoprotein Gene Contributes to the Enhanced Apoptosis Induced by Wild-Type Rabies Virus GD-SH-01 In Vitro

Frontiers in Microbiology, 2017
Previous research demonstrated that the matrix protein (M) and glycoprotein (G) of attenuated rabies virus (RABV) strains are involved in the induction of host cell apoptosis.
Qin Tian, Qin Tian, Yifei Wang, Yifei Wang, Qiong Zhang, Qiong Zhang, Jun Luo, Jun Luo, He Jiang, He Jiang, Boyue Zhang, Boyue Zhang, Mingzhu Mei, Mingzhu Mei, Fan Wu, Fan Wu, Yuting Wu, Yuting Wu, Jiaojiao Peng, Jiaojiao Peng, Teng Long, Teng Long, Yongwen Luo, Yongwen Luo, Xiaofeng Guo, Xiaofeng Guo   +25 more
doaj   +1 more source

Single‐Cell and Spatial Transcriptomics Unveil Key Regulators Governing Cell Differentiation for Schistosoma japonicum Sexual Development

Advanced Science, EarlyView.
Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu, Xiaoxu Wang, Shun Li, Xuxin Li, Pengfei Du, Yameng Zheng, Lu Liu, Yanyan Zhang, Omri Wurtzel, Guofeng Cheng   +9 more
wiley   +1 more source

Rapid, Multiplexed Phosphoprotein Profiling Using Silicon Photonic Sensor Arrays

, 2015
Extracellular signaling is commonly mediated through post-translational protein modifications that propagate messages from membrane-bound receptors to ultimately regulate gene expression.
Johnson, Mark, Wade, James H., Yang, Hongwei, Mark D. Johnson, Hongwei Yang (1367979), Bailey, Ryan C., Aurora T. Alsop, Nicholas R. Vertin, Ryan C. Bailey (482859), Nicholas R. Vertin (1367976), Alsop, Aurora T., James H. Wade, Hongwei Yang, Vertin, Nicholas R., Ryan C. Bailey, Mark D. Johnson (1367970), James H. Wade (1367967), Aurora T. Alsop (1367973)   +17 more
core   +1 more source

Unexpected catalytic site variation in phosphoprotein phosphatase homologues of cofactor-dependent phosphoglycerate mutase [PDF]

, 2003
The cofactor-dependent phosphoglycerate mutase (dPGM) superfamily contains, besides mutases, a variety of phosphatases, both broadly and narrowly substrate-specific.
Rigden, Daniel J., Daniel J. Rigden
core   +1 more source