Results 71 to 80 of about 81,959 (297)

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Structure of the tetramerization domain of measles virus phosphoprotein.

, 2013
International audienceThe atomic structure of the stable tetramerization domain of the measles virus phosphoprotein shows a tight four-stranded coiled coil. Although at first sight similar to the tetramerization domain of the Sendai virus phosphoprotein,
Jensen, Malene Ringkjøbing, Crépin, Thibaut, Maurin, Damien, Communie, Guillaume, Blackledge, Martin, Ruigrok, Rob W H   +5 more
core   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

SITES OF FORMATION OF PLASMA PHOSPHOPROTEIN AND PHOSPHOLIPID IN THE ESTROGENIZED COCKEREL

, 1957
Estrogen increased plasma Ca, but not plasma total protein, phosphoprotein P, or phospholipid P, in functionally hepatectomized cockerels. Estrogen increased all four plasma constituents in sham-operated cockerels.
W. E. Vanstone, D. G. Dale, W. F. Oliver, R. H. Common   +3 more
core   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

The effect of two different types of forces on possible root resorption in relation to dentin phosphoprotein levels: a single-blind, split-mouth, randomized controlled trial

Progress in Orthodontics, 2021
Background The purpose of this 2-arm-parallel split-mouth trial was to evaluate and compare the extent of possible root resorption using dentin phosphoprotein levels in gingival crevicular fluid between controlled continuous and intermittent orthodontic ...
Sherifa Ghaleb, Nazla Tamish, Walid ElKenany, Myriam Guindi   +3 more
doaj   +1 more source

Secreted phosphoprotein 1 expression in endometrium and placental tissues of Hyperprolific Large White and Meishan gilts

, 2013
Chantier qualité GAIncreased litter size and within-litter uniformity in birth weight would improve pig reproductive efficiency. This study compared the location and gene and protein expression of secreted phosphoprotein 1 in placental and uterine ...
Billon, Yvon, Ashworth, Cheryl J., C. J., Hogg, Charis O., C. O., Sanchez, Marie-Pierre, Archibald, Alan L., A. L., Bidanel, Jean Pierre, Hernandez, Silvia C., S. C., Haley, Christopher S., C. S.   +7 more
core   +1 more source

The molybdate-stabilized glucocorticoid binding complex of L-cells contains a 98-100 kdalton steroid binding phosphoprotein and a 90 kdalton nonsteroid-binding phosphoprotein that is part of the murine heat-shock complex [PDF]

, 1986
This paper summarizes our work performed with glucocorticoid-binding complexes in molybdate-stabilized cytosol prepared from 32P-labeled L-cells. In our early work, we showed that cytosol prepared from 32P-labeled L-cells contains two phosphoproteins (a ...
Sanchez, Edwin R., Pratt, William B., Housley, Paul R.   +2 more
core   +1 more source

Macrophage‐to‐Myofibroblast Transdifferentiation Contributes to Pulmonary Fibrosis via the MERTK‐SPP1‐SRC‐TKS5 Signaling Axis

Advanced Science, EarlyView.
MERTK is upregulated in fibrotic macrophages and regulates the expression and activity of SRC and TKS5 through SPP1, mediating transdifferentiation of macrophages‐to‐myofibroblasts (MMT) and promoting pulmonary fibrosis. The figure was created with BioRender.com.
Yungeng Wei, Hua Guo, Xiangsheng Yang, Xiao Xiao Tang   +3 more
wiley   +1 more source

The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex

mBio, 2018
Human respiratory syncytial virus (HRSV) is a negative-stranded RNA virus that causes a globally prevalent respiratory infection, which can cause life-threatening illness, particularly in the young, elderly, and immunocompromised.
Muniyandi Selvaraj, Kavestri Yegambaram, Eleanor J. A. A. Todd, Charles-Adrien Richard, Rachel L. Dods, Georgia M. Pangratiou, Chi H. Trinh, Sophie L. Moul, James C. Murphy, Jamel Mankouri, Jean-François Éléouët, John N. Barr, Thomas A. Edwards   +12 more
doaj   +1 more source