Results 71 to 80 of about 87,699 (269)
Advanced Science, EarlyView.Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su +7 more
wiley +1 more source
Journal of Advanced Biotechnology and Experimental Therapeutics, 2018 VGF (non-acronymic), belonging to a large granin family, gives rise to a number of bioactive peptides by proteolysis and exert an extensive array of biological effects on energy metabolism, pain modulation, gastric secretion function, reproduction, mood ...
Md Shamim Akhter +1 more
doaj +1 more source
Advanced Science, EarlyView.Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai +9 more
wiley +1 more source
Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis
Advanced Science, EarlyView.A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa +5 more
wiley +1 more source
, 2005 Novel Galpha13 signaling partners: Serotonin 5HT4a receptor and vasodilator-stimulated ...
Jasmina. Profirovic (7989293)
core +6 more sources
Advanced Science, EarlyView.Single‐cell mechanomics demonstrates that pharmacological perturbation changes cytoskeletal and cortical structure, suppressing cancer cell invasiveness. By integrating atomic force microscopy (AFM)‐based cortical measurements with stimulated emission depletion (STED)‐resolved adhesion and cytoskeletal organization, this approach identifies nanoscale ...
Minhee Ku +4 more
wiley +1 more source
Immunohistochemistry of colorectal cancer biomarker phosphorylation requires controlled tissue fixation. [PDF]
PLoS ONE, 2014 Phosphorylated signaling molecules are biomarkers of cancer pathophysiology and resistance to therapy, but because phosphoprotein analytes are often labile, poorly controlled clinical laboratory practices could prevent translation of research findings in
Abbey P Theiss +4 more
doaj +1 more source
Structure of the tetramerization domain of measles virus phosphoprotein.
, 2013 International audienceThe atomic structure of the stable tetramerization domain of the measles virus phosphoprotein shows a tight four-stranded coiled coil. Although at first sight similar to the tetramerization domain of the Sendai virus phosphoprotein,
Jensen, Malene Ringkjøbing +5 more
core +1 more source
Advanced Science, EarlyView.Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh +22 more
wiley +1 more source
SITES OF FORMATION OF PLASMA PHOSPHOPROTEIN AND PHOSPHOLIPID IN THE ESTROGENIZED COCKEREL
, 1957 Estrogen increased plasma Ca, but not plasma total protein, phosphoprotein P, or phospholipid P, in functionally hepatectomized cockerels. Estrogen increased all four plasma constituents in sham-operated cockerels.
W. E. Vanstone +3 more
core +1 more source