Results 51 to 60 of about 81,959 (297)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Sequence homology between purple acid phosphatases and phosphoprotein phosphatases Are phosphoprotein phosphatases metalloproteins containing oxide-bridged dinuclear metal centers?

, 1990
The amino acid sequences of mammalian purple acid phosphatases and phosphoprotein phosphatases are shown to possess regions of significant homology. The conserved residues contain a high percentage of possible metal-binding residues.
Averill, Bruce A., John B. Vincent, Vincent, John B., Bruce A. Averill   +3 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Phosphoprotein Gene of Wild-Type Rabies Virus Plays a Role in Limiting Viral Pathogenicity and Lowering the Enhancement of BBB Permeability

Frontiers in Microbiology, 2020
Enhancement of blood–brain barrier (BBB) permeability is necessary for clearing virus in the central nervous system (CNS). It has been reported that only laboratory-attenuated rabies virus (RABV) induces inflammatory response to lead BBB transient ...
Teng Long, Boyue Zhang, Ruqi Fan, Yuting Wu, Meijun Mo, Jun Luo, Yiran Chang, Qin Tian, Mingzhu Mei, He Jiang, Yongwen Luo, Xiaofeng Guo   +11 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Leucine-Rich Repeat Kinase 1 Signaling Targets Proteins Critical for Endosome/Lysosome Sorting and Trafficking in Osteoclasts

Biology
Global knockout (KO) of the Lrrk1 gene in mice causes severe osteopetrosis because of the failure of osteoclasts to resorb bone. The molecular mechanism of LRRK1 regulation of osteoclast function is not fully understood.
Weirong Xing, Yian Chen, Anakha Udayakumar, Haibo Zhao, Subburaman Mohan   +4 more
doaj   +1 more source

Phosphoprotein Profiling by PA-GeLC−MS/MS

, 2016
A significant consequence of protein phosphorylation is to alter protein−protein interactions, leading to dynamic regulation of the components of protein complexes that direct many core biological processes.
Stephen J. Kron (2108671), Kolbrun Kristjansdottir (2432182), David Sigfredo Angulo (2432179), Donald Wolfgeher (2432176), Nick Lucius (2432185)   +4 more
core   +1 more source

Interface‐Engineered Binary Framework Composites: Advancing Porous Materials for Precision Medicine

Advanced Materials Interfaces, EarlyView.
Binary framework composites integrate two complementary porous architectures into a unified platform, enabling multifunctional design, enhanced structural tunability, and improved physicochemical performance. By combining high surface area, ordered porosity, interfacial synergy, and versatile functionalization, these hybrid materials offer new ...
Navid Rabiee, Mohammad Rabiee, Mohammad Akrami‐Hasan‐Kohal, Sidi A. Bencherif   +3 more
wiley   +1 more source

Heterologous Caseins: The Role of Phosphorylation in Their Functionality and How to Achieve It

Biomolecules
Heterologous expression of caseins in non-mammalian systems offers a sustainable and scalable alternative for producing milk proteins, with potential applications in the food and biopharmaceutical industries.
Soledad Mora Vásquez, Santiago García-Jacobo, Guy A. Cardineau, Silverio García-Lara   +3 more
doaj   +1 more source

Phosphoprotein Gene Contributes to the Enhanced Apoptosis Induced by Wild-Type Rabies Virus GD-SH-01 In Vitro

Frontiers in Microbiology, 2017
Previous research demonstrated that the matrix protein (M) and glycoprotein (G) of attenuated rabies virus (RABV) strains are involved in the induction of host cell apoptosis.
Qin Tian, Qin Tian, Yifei Wang, Yifei Wang, Qiong Zhang, Qiong Zhang, Jun Luo, Jun Luo, He Jiang, He Jiang, Boyue Zhang, Boyue Zhang, Mingzhu Mei, Mingzhu Mei, Fan Wu, Fan Wu, Yuting Wu, Yuting Wu, Jiaojiao Peng, Jiaojiao Peng, Teng Long, Teng Long, Yongwen Luo, Yongwen Luo, Xiaofeng Guo, Xiaofeng Guo   +25 more
doaj   +1 more source