Results 51 to 60 of about 87,699 (269)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

In vitro mineral induction by immobilized phosphoprotein : Effect of phosphate group on interfacial tension for mineral induction [PDF]

, 1999
P(論文)Phosphoproteins are thought to play a primary role in the deposition of mineral on the collagen of dentin. We previously reported that immobilized phosphoproteins reduced activation energy for mineral induction in metastable mineralizing solutions ...
SAITO, Takashi, 25440, 25442, ITO, Shuichi, 25441, TOYOOKA, Hiroki, MATSUDA, Koichi, 25443, CRENSHAW, Miles A., 25439   +9 more
core  

DAB2 (disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)) [PDF]

, 2010
Review on DAB2 (disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)), with data on DNA, on the protein encoded, and where the gene is ...
M Orlandini, Orlandini, M, ORLANDINI, MAURIZIO   +2 more
core   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Phosphoprotein Gene of Wild-Type Rabies Virus Plays a Role in Limiting Viral Pathogenicity and Lowering the Enhancement of BBB Permeability

Frontiers in Microbiology, 2020
Enhancement of blood–brain barrier (BBB) permeability is necessary for clearing virus in the central nervous system (CNS). It has been reported that only laboratory-attenuated rabies virus (RABV) induces inflammatory response to lead BBB transient ...
Teng Long, Boyue Zhang, Ruqi Fan, Yuting Wu, Meijun Mo, Jun Luo, Yiran Chang, Qin Tian, Mingzhu Mei, He Jiang, Yongwen Luo, Xiaofeng Guo   +11 more
doaj   +1 more source

Biosynthesis of Phosphoprotein in the Frog

Experimental Biology and Medicine, 1958
SummaryIntraperitoneal administration of radioactive phosphorus to Rana esculenta resulted in an appreciable incorporation of the isotope in the phosphoprotein fraction of liver and very much less in the corresponding fraction of ovary. The presence, in liver, of a metabolically active phosphopeptide, was demonstrated.
K S, SAMPATH KUMAR, T A, SUNDARARAJAN, P S, SARMA   +2 more
openaire   +2 more sources

The Assembly of the Measles Virus Nucleoprotein into Nucleocapsid-like Particles Is Modulated by the Phosphoprotein [PDF]

, 1997
Measles virus nucleoprotein encoded from the vaccinia virus genome assembles into nucleocapsids similar in many respects to those observed during a natural measles virus infection.
Drillien, Robert, Spehner, Danièle, Howley, Paul M.   +2 more
core   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Leucine-Rich Repeat Kinase 1 Signaling Targets Proteins Critical for Endosome/Lysosome Sorting and Trafficking in Osteoclasts

Biology
Global knockout (KO) of the Lrrk1 gene in mice causes severe osteopetrosis because of the failure of osteoclasts to resorb bone. The molecular mechanism of LRRK1 regulation of osteoclast function is not fully understood.
Weirong Xing, Yian Chen, Anakha Udayakumar, Haibo Zhao, Subburaman Mohan   +4 more
doaj   +1 more source