Results 41 to 50 of about 19,090 (263)

Synthetic trap-peptides identify a TOM complex phosphatase - PP2A dephosphorylates Tom6. [PDF]

FEBS J
Synthetic trap‐peptides facilitate the identification of complete holoenzymes that bind to the target sequence remarkably close to the phosphorylation site. PP4 bound to, but did not dephosphorylate, the peptide substrate taken from yeast Tom6 pSer16, showing that proximity alone does not induce phosphatase activity.
Scheinost L, Ludwig C, Höfflin N, Taskin AA, Marada A, Vögtle FN, Meisinger C, Köhn M.   +7 more
europepmc   +2 more sources

Phospho-Proteomics Identifies D-Group MAP Kinases as Substrates of the <i>Arabidopsis</i> Tyrosine Phosphatase RLPH2. [PDF]

Plant Direct
ABSTRACT Despite being one of the few bona fide plant tyrosine phosphatases, the Arabidopsis thaliana Rhizobiales‐like phosphatase 2 (RLPH2) has no known substrates. Utilizing phospho‐proteomics, we identified the activation loop phospho‐tyrosine of several A. thaliana D‐group mitogen‐activated protein kinases (MPKs) as potential RLPH2 substrates.
Labandera AM, Toth R, Mitchell S, Johnson JJ, Kurucz B, Puyaubert J, Baudouin E, Uhrig RG, Moorhead GB.   +8 more
europepmc   +2 more sources

Special Sensitization Pattern in Adenosine-Induced Myocardial Responses After Thyroxine-Treatment

Journal of Pharmacological Sciences, 2003
Chronic thyroxine treatment reduces the susceptibility of atrial myocardium to adenosine. While the possible role of membrane adenosine receptors in this action is supported by several studies, the involvement of intracellular adenosine mechanisms has ...
Rudolf Gesztelyi, Judit Zsuga, Ágnes Cseppentõ, Ágnes Bajza, Judit Zs. Szabó, József Szentmiklósi   +5 more
doaj   +1 more source

LRRK2 Kinase Activity and Biology are Not Uniformly Predicted by its Autophosphorylation and Cellular Phosphorylation Site Status

Frontiers in Molecular Neuroscience, 2014
Missense mutations in the Leucine Rich Repeat protein Kinase 2 (LRRK2) gene are the most common genetic predisposition to develop Parkinson’s disease (PD) LRRK2 is a large multi-domain phosphoprotein with a GTPase domain and a serine/threonine protein ...
April eReynolds, Elizabeth A Doggett, Steven M. Riddle, Connie S Lebakken, R. Jeremy eNichols   +4 more
doaj   +1 more source

PiTRAQ, a strategy to simultaneously correlate protein expression and phosphorylation stoichiometry between different samples: evaluation on different mass spectrometers [PDF]

, 2013
C
Colaert, Niklaas, Deforce, Dieter, Dhaenens, Maarten, Glibert, Pieter, Martens, Lennart, Meert, Paulien, Van Nieuwerburgh, Filip   +6 more
core   +1 more source

Protein Phosphatase 2A in the Regulatory Network Underlying Biotic Stress Resistance in Plants [PDF]

, 2016
Biotic stress factors pose a major threat to plant health and can significantly deteriorate plant productivity by impairing the physiological functions of the plant.
Alegre, Sara, Brosche, Mikael, Durian, Guido, Kangasjarvi, Saijaliisa, Rahikainen, Moona   +4 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Sequence homology between purple acid phosphatases and phosphoprotein phosphatases [PDF]

FEBS Letters, 1990
The amino acid sequences of mammalian purple acid phosphatases and phosphoprotein phosphatases are shown to possess regions of significant homology. The conserved residues contain a high percentage of possible metal‐binding residues. The phosphoprotein phosphatases 1, 2A and 2B are proposed to be iron‐zinc metalloenzymes with active sites isostructural
Vincent, John B., Averill, Bruce A.
openaire   +2 more sources

Phosphorylation by protein kinase C and the responsiveness of Mg2+-ATPase to Ca2+ of myofibrils isolated from stunned and non-stunned porcine myocardinm [PDF]

, 1997
Previously we showed in an in situ porcine model that the thiadiazinone derivative [+]EMD 60263, a Ca2+ sensitizer without phosphodiesterase III inhibitory properties, increased contractility more profoundly in stunned than in non-stunned myocardium ...
Bezstarosti, K. (Karel), Lamers, J.M.J. (Jos), Soei, L.K. (Lou Kie), Verdouw, P.D. (Pieter)   +3 more
core   +3 more sources

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source