Results 51 to 60 of about 19,090 (263)

Phosphoinositides in the Hepatitis C Virus Life Cycle

Viruses, 2012
Eukaryotes possess seven different phosphoinositides (PIPs) that help form the unique signatures of various intracellular membranes. PIPs serve as docking sites for the recruitment of specific proteins to mediate membrane alterations and integrate ...
Aleem Siddiqui, Bryan Bishé, Gulam Syed
doaj   +1 more source

3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research

Advanced Functional Materials, EarlyView.
A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram, Majd Machour, Janette Zavin, Roy Meretzki, Reut Lev‐Ari, Shulamit Levenberg   +5 more
wiley   +1 more source

Centromeric binding and activity of Protein Phosphatase 4 [PDF]

, 2015
The cell division cycle requires tight coupling between protein phosphorylation and dephosphorylation. However, understanding the cell cycle roles of multimeric protein phosphatases has been limited by the lack of knowledge of how their diverse ...
Glover, David M., Lefevre, Stephane, Lipinszki, Zoltan, Przewloka, Marcin, Savoian, Matthew S., Singleton, Martin R.   +5 more
core   +1 more source

Cell Calcification Models and Their Implications for Medicine and Biomaterial Research

Advanced Healthcare Materials, EarlyView.
Calcification, is the process by which the tissues containing minerals are formed, occurring during normal physiological processes, or in pathological conditions. Here, it is aimed to give a comprehensive overview of the range of cell models available, and the approaches taken by these models, highlighting when and how methodological divergences arise,
Luke Hunter, Caterina Vanelli Coralli, Robert Dzhanaev, Aaron Morgan, Willi Jahnen‐Dechent, Sergio Bertazzo   +5 more
wiley   +1 more source

Regulation of Op18 during Spindle Assembly in Xenopus Egg Extracts [PDF]

, 2001
Oncoprotein 18 (Op18) is a microtubule-destabilizing protein that is negatively regulated by phosphorylation. To evaluate the role of the three Op18 phosphorylation sites in Xenopus (Ser 16, 25, and 39), we added wild-type Op18, a nonphosphorylatable ...
Andersen, Andersen, Arnaud, Bahler, Belmont, Brattsand, Carmena, Cassimeris, Charles, Curmi, Curmi, Desai, Desai, Descombes, Di Paolo, Felix, Gard, Gavet, Gigant, Glover, Golsteyn, Gruss, Hamanaka, Heald, Heald, Heald, Heald, Hirano, Horwitz, Howell, Howell, Hyman, Jourdain, Karaiskou, Kotani, Kumagai, Kumagai, Lane, Larsson, Lawler, Llamazares, Logarinho, Luo, Marklund, Maucuer, McKim, Moutinho-Santos, Murray, Nachury, Nigg, Ohkura, Qian, Qian, Sandaltzopoulos, Sawin, Schubart, Shirayama, Steinmetz, Sunkel, Taagepera, Tournebize, Vernos, Walczak, Wallon, Wianny, Wiese, Wray, Zhang   +67 more
core   +4 more sources

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

Isolation of human mitotic protein phosphatase complexes: identification of a complex between protein phosphatase 1 and the RNA helicase Ddx21.

PLoS ONE, 2012
Metazoan mitosis requires remodelling of sub-cellular structures to ensure proper division of cellular and genetic material. Faults often lead to genomic instability, cell cycle arrests and disease onset.
Veerle De Wever, David C Lloyd, Isha Nasa, Mhairi Nimick, Laura Trinkle-Mulcahy, Robert Gourlay, Nick Morrice, Greg B G Moorhead   +7 more
doaj   +1 more source

Activation of Ciona sperm motility: phosphorylation of dynein polypeptides and effects of a tyrosine kinase inhibitor [PDF]

, 1991
A high molecular mass dynein ATPase polypeptide and a 18–20 kDa dynein light chain of Ciona sperm flagella are phosphorylated during in vivo activation of motility or in vitro activation of motility by incubation with cyclic AMP.
Brokaw, Charles J., Dey, Chinmoy S.
core  

Protein phosphatase beta, a putative type-2A protein phosphatase from the human malaria parasite Plasmodium falciparum. [PDF]

, 1997
Protein phosphatases play a critical role in the regulation of the eukaryotic cell cycle and signal transduction. A putative protein serine/threonine phosphatase gene has been isolated from the human malaria parasite Plasmodium falciparum.
Arndt K. T., Barton G. J., Bruce M. C., Chen J., Chen J., Day K. P., Favre B., Kamibayashi C., Kennelly P. I., Lee J., Li I. L., Lin F. C., Lorca T., Nussenzweig R. S., Pallas D. C., Posas F., Rangachari K., Read L. K., Ronne H., Ross-MacDonald P. B., Shima H., Snaith H. A., Sneddon A. A., Stone S. R., Sutton A., Wera S., Xie H., Zhang Z., Zhang Z., Zhao Y., Zhao Y., Zhuo S., Zolnierowicz S.   +32 more
core   +1 more source

Cholesterol‐DNA Origami Nanostructures for Synthetic Lipid Rafts Induce Early T Cell Activation Signals

Advanced Materials Interfaces, EarlyView.
Here, we present a nanotechnology approach to construct synthetic lipid rafts on the live T cell membrane, leveraging a versatile DNA origami‐enabled platform named as the “cholesterol nano‐patch” (CNP). Our investigation highlights the effectiveness of DNA nanotechnology in exploring the impact of nanoscale arrangement of cholesterols on the ...
Yunmin Jung, Young‐Joo Kim, Kunwoo Noh, Sunmi Lee, Minsuk Kwak   +4 more
wiley   +1 more source