ABSTRACT Background Critically ill patients requiring intensive care unit (ICU) admission suffer from muscle weakness that persists for years. Recently, altered RNA expression was documented in muscle of former ICU patients 5 years after critical illness that suggested disrupted mitochondrial function, disturbed lipid metabolism and fibrosis, of which ...
Ceren Uzun Ayar +4 more
wiley +1 more source
Phosphopeptidome Profiling of Human Plasma for Hepatocellular Carcinoma Biomarker Discovery. [PDF]
Saleem S +5 more
europepmc +1 more source
Differences in Src phosphorylation of PSD‐93 and PSD‐95 drive differences in scaffolding activity
Abstract Scaffold proteins contain multiple binding modules that allow for co‐localization of proteins that lack a direct interaction. Evolution resulted in different combinations of binding modules that rewired existing signal transduction pathways.
Frank A. Mindlin +3 more
wiley +1 more source
Integrated proteomic and phosphoproteomic profiling demonstrated that protein kinase MoCK2 modulated mitochondrial energetics, ribosomal biogenesis, and cellular signaling networks in rice blast fungus, Magnaporthe oryzae. [PDF]
Zhang L +14 more
europepmc +1 more source
ABSTRACT Background Microscopic colitis (MC), comprising lymphocytic colitis (LC) and collagenous colitis (CC), is an inflammatory bowel disease with increasing incidence. MC etiopathogenesis remains unknown; however, altered colonic epithelial integrity may underlie uncontrolled luminal antigen passage, triggering immuno‐inflammatory responses ...
Danila Guagnozzi +18 more
wiley +1 more source
Phosphoprotein Profile of Ameloblastoma. [PDF]
Sanguansin S +6 more
europepmc +1 more source
Hevin Promotes Aging‐Related Cardiac Dysfunction via Facilitating Cardiac Inflammation in Male Mice
Hevin released by iWAT into circulation stimulates cardiac macrophages through TLR4, inducing their polarization and CCL5 secretion, leading to worsened cardiac dysfunction and subsequent recruitment of additional inflammatory cells for pro‐inflammatory factor release.
Shi‐Yu Huang +4 more
wiley +1 more source
Phosphoproteomic Analysis Reveals Impairment of Rice Germination by Chloramphenicol. [PDF]
Li R +4 more
europepmc +1 more source
Regulation of transformation-sensitive secreted phosphoprotein (SPPI/osteopontin) expression by transforming growth factor-β. Comparisons with expression of SPARC (secreted acidic cysteine-rich protein) [PDF]
Jeffrey L. Wrana +6 more
openalex +1 more source

