Results 191 to 200 of about 36,892 (294)

Endogenous Bornavirus‐Like Nucleoprotein 1 Regulates Cellular Processes and DNA Double‐Strand Breaks in U‐87 MG Glioblastoma Cells

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Glioblastoma (GBM) is a common brain cancer with a poor prognosis and a high recurrence rate. DNA damage repair plays a crucial role in GBM carcinogenesis and treatment resistance. Human endogenous bornavirus‐like nucleoprotein 1 (EBLN1) regulates cellular processes and genetic stability. However, the biological role of EBLN1 in GBM
Jing Liang, Dongdong Zeng, Yujie Guo, Cuiyuan Jing, Lin Tang, Zhanpeng Luo, Peng He   +6 more
wiley   +1 more source

Deciphering the Protein Phosphorylation Dynamics Triggered by Seconds of Force Stimulation. [PDF]

Mol Cell Proteomics
Yang N, Sing Pun S, Wong EOY, Dai S, Li X, Leung M, Burlingame A, Wang ZY, Yang M, Lu Y, An Y, Zhang Y, Yang Z, Yu W, Li N.   +14 more
europepmc   +1 more source

Dysregulated circRNA expression profile and associated miRNA sponging in abnormal lung development in congenital diaphragmatic hernia

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Circular RNAs (circRNAs) are stable, stage‐ and tissue‐specific regulators of gene expression warranting their study in abnormal fetal lung development in congenital diaphragmatic hernia (CDH). We present a CDH‐specific circRNA biosignature in the nitrofen rat model (E15/E21) using orthogonal validation with human comparison and discovered conserved ...
Marietta Jank, Arzu Ozturk Aptekmann, Rina Tanaka, Muntahi Mourin, Nolan De Leon, Matthew Kraljevic, Daywin Patel, Wai Hei Tse, Claire McCallum, Richard Wagner, Shana Kahnamoui, Yuichiro Miyake, Athanasios Zovoilis, Takashi Doi, Michael Boettcher, Richard LeDuc, Richard Keijzer   +16 more
wiley   +1 more source

Uncovering the signaling networks of disseminated glioblastoma cells in vivo with INSIGHT. [PDF]

Nat Commun
Ahn R, D'Souza AD, Long L, Cui Y, Gantchev J, Baquer G, Burgenske D, Bakken KK, Ott LL, Carlson BL, Zhou G, Kohale IN, Whittaker CA, Temple H, Yaron-Barir TM, Wyckoff J, Burns TC, Vaubel RA, Flower CT, Huang W, Tuma A, Johnson JL, Agar NYR, Ursini-Siegel J, Jann S, White FM.   +25 more
europepmc   +1 more source

Tryptophan metabolism in colorectal cancer: From mechanistic insights to novel therapeutic strategies

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Tryptophan metabolism modulates CRC via three microbiota‐regulated pathways with distinct dual‐mode effects. The kynurenine pathway provides biomarkers, serotonin pathway supports SSRI‐combined immunotherapy, indole pathway yields immunostimulatory metabolites, collectively offering translational prospects.
Ran Wang, Wenke Shen, Ping Yang, Dongxue Yang, Yuepeng Cao, Yuping Zhou   +5 more
wiley   +1 more source

Deciphering Site-Specific Regulatory Networks of the Kinesin Protein KIF21A Through Integrative Phosphoproteomic Analysis. [PDF]

Int J Mol Sci
Rai SB, Sujina A, Ahmed M, Kammarambath SR, Subair S, Gopalakrishnan AP, Kalasa Anil Kumar AP, John L, Raju R, Palollathil A.   +9 more
europepmc   +1 more source

Spatiotemporal immune heterogeneity and precision immunotherapy for ovarian cancer

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Graphical Highlights Spatiotemporal immune heterogeneity shapes distinct and evolving immune ecosystems in ovarian cancer. Multimodal biomarkers enable biologically informed patient stratification beyond static single‐marker approaches. Precision immunotherapy should match dominant immune barriers across lesions and treatment stages.
Xinfeng Yang, Yida Wang, Haiyue You, Jingyi Gao, Yangkun Feng, Feng Zhang, Yan Zhang, Bing Zhang, Shaojie Zhao, Yanfang Gu   +9 more
wiley   +1 more source

PD-1/LAG-3 signaling rewires T-cells via MYC inhibition. [PDF]

Signal Transduct Target Ther
Chocarro L, Fernández-Rubio L, Ausin K, Blanco E, Echaide M, Vilaplana B, Santamaría E, Fernández-Irigoyen J, Kochan G, Escors D.   +9 more
europepmc   +1 more source

Fisetin Attenuates Amyloid‐Beta‐Induced Neurotoxicity in Human Neuroblastoma SH‐SY5Y Cells: Integrating In Silico Target Prediction and In Vitro Validation

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
The in‐silico data showed that fisetin binds stably with the autophagy receptors and synaptic density regulators. Further, in‐vitro data confirmed the restoration of Aβ1‐42 disrupted autophagy by fisetin. Fisetin restored the oxidative stress and ion channels, along with a reduction of AChE activity.
Charu Jaiswal, Ishika Singh, Abhishek Kumar Singh   +2 more
wiley   +1 more source

Phosphoproteomic Profiling Reveals Overlapping and Distinct Signaling Pathways in <i>Dictyostelium discoideum</i> in Response to Two Different Chemorepellents. [PDF]

Cells
Uddin SZ, Rijal R, Pilling D, Gomer RH.
europepmc   +1 more source