Results 1 to 10 of about 20,263 (273)
Clinical Applications of Phosphoproteomics: Illuminating Cancer Signaling and Enabling Rational Therapeutic Strategies. [PDF]
Cancer SciMass spectrometry‐based phosphoproteomics for mechanistic dissection of cancer signaling pathways and uncovering therapeutic vulnerabilities. ABSTRACT Protein phosphorylation is a central post‐translational modification regulating cellular signaling, frequently dysregulated in cancer.
Shoji H, Boku N, Adachi J.
europepmc +2 more sources
Multi-proteomic profiling indicates potential regulatory signatures underlying rice resistance to Magnaporthe oryzae. [PDF]
Plant JSUMMARY Omics‐driven approaches can capture systemic plant responses to pathogens. While transcriptomics is a mainstay, it alone cannot capture post‐translational modifications or protein abundance. Because of this, we employed multi‐proteomics to compare the proteome, phosphoproteome, and acetylome of two rice genotypes differing in resistance to ...
Auler PA +5 more
europepmc +2 more sources
Cross-Species Analysis of ABA-Induced Phosphosignaling Landscapes in Rice, Soybean, and Arabidopsis [PDF]
ProteomesBackground: Abscisic acid (ABA) is a key phytohormone that regulates plant growth and stress responses through protein phosphorylation. While ABA-induced phosphosignaling has been extensively studied in Arabidopsis thaliana, its conservation and ...
Hinano Takase +8 more
doaj +2 more sources
Molecular Responses to Climate Change: How Warming and Acidification Reshape the Proteome and Phosphoproteome of the Endangered Mira Chub. [PDF]
Ecol EvolMoreno JM +5 more
europepmc +3 more sources
Phosphoproteome Discovery in Human Biological Fluids
Proteomes, 2016 Phosphorylation plays a critical role in regulating protein function and thus influences a vast spectrum of cellular processes. With the advent of modern bioanalytical technologies, examination of protein phosphorylation on a global scale has become one ...
Francesco Giorgianni
exaly +3 more sources
Cells, 2021 To investigate the biological role of protein phosphorylation in human nonfunctional pituitary neuroendocrine tumors (NF-PitNETs), proteins extracted from NF-PitNET and control tissues were analyzed with tandem mass tag (TMT)-based quantitative ...
Jiajia Li +4 more
doaj +1 more source
BMC Plant Biology, 2021 Background Proteins are the workforce of the cell and their phosphorylation status tailors specific responses efficiently. One of the main challenges of phosphoproteomic approaches is to deconvolute biological processes that specifically respond to an ...
Denise S. Arico +3 more
doaj +1 more source
Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source
Phosphoproteome Dynamics of Streptomyces rimosus during Submerged Growth and Antibiotic Production
mSystems, 2022 Streptomyces rimosus is an industrial streptomycete, best known as a producer of oxytetracycline, one of the most widely used antibiotics. Despite the significant contribution of Streptomyces species to the pharmaceutical industry, most omics analyses ...
Ela Šarić +10 more
doaj +1 more source