Results 1 to 10 of about 12,382 (182)

Phosphoproteome Study of Escherichia coli Devoid of Ser/Thr Kinase YeaG During the Metabolic Shift From Glucose to Malate

Frontiers in Microbiology, 2021
Understanding phosphorylation-mediated regulation of metabolic enzymes, pathways, and cell phenotypes under metabolic shifts represents a major challenge.
Abida Sultan, Carsten Jers, Tariq A. Ganief, Lei Shi, Meriem Senissar, Julie Bonne Køhler, Boris Macek, Ivan Mijakovic, Ivan Mijakovic   +8 more
doaj   +1 more source

Integrated proteomics and phosphoproteomics revealed druggable kinases in neoadjuvant chemotherapy resistant tongue cancer

Frontiers in Cell and Developmental Biology, 2022
Tongue squamous cell carcinoma is an aggressive oral cancer with a high incidence of metastasis and poor prognosis. Most of the oral cavity cancer patients present in clinics with locally advanced unresectable tumors.
Irene A. George, Irene A. George, Gajanan Sathe, Gajanan Sathe, Vivek Ghose, Vivek Ghose, Anuradha Chougule, Pratik Chandrani, Vijay Patil, Vanita Noronha, R. Venkataramanan, Sewanti Limaye, Akhilesh Pandey, Akhilesh Pandey, Akhilesh Pandey, Akhilesh Pandey, Kumar Prabhash, Prashant Kumar, Prashant Kumar, Prashant Kumar   +19 more
doaj   +1 more source

Phosphoproteomics reveals that cinobufotalin promotes intrahepatic cholangiocarcinoma cell apoptosis by activating the ATM/CHK2/p53 signaling pathway

Frontiers in Oncology, 2022
Intrahepatic cholangiocarcinoma (ICC) is a malignant tumor that originates from bile duct’s epithelial cells and is usually characterized by insidious symptoms and poor prognosis.
Zhili Xia, Minzhen Li, Meng Hu, Yanyan Lin, Yanyan Lin, Lawrence Lawer Atteh, Wenkang Fu, Long Gao, Mingzhen Bai, Chongfei Huang, Ping Yue, Ping Yue, Yu Liu, Wenbo Meng, Wenbo Meng, Wenbo Meng   +15 more
doaj   +1 more source

Assessment of Protein Content and Phosphorylation Level in Synechocystis sp. PCC 6803 under Various Growth Conditions Using Quantitative Phosphoproteomic Analysis

Molecules, 2020
The photosynthetic apparatus and metabolic enzymes of cyanobacteria are subject to various controls, such as transcriptional regulation and post-translational modifications, to ensure that the entire cellular system functions optimally.
Masakazu Toyoshima, Yuma Tokumaru, Fumio Matsuda, Hiroshi Shimizu   +3 more
doaj   +1 more source

Reprogramming of cardiac phosphoproteome, proteome, and transcriptome confers resilience to chronic adenylyl cyclase-driven stress

eLife
Our prior study (Tarasov et al., 2022) discovered that numerous adaptive mechanisms emerge in response to cardiac-specific overexpression of adenylyl cyclase type 8 (TGAC8) which included overexpression of a large number of proteins.
Jia-Hua Qu, Khalid Chakir, Kirill V Tarasov, Daniel R Riordon, Maria Grazia Perino, Allwin Jennifa Silvester, Edward G Lakatta   +6 more
doaj   +1 more source

Comparative Proteome and Phosphoproteome Analyses Reveal Different Molecular Mechanism Between Stone Planting Under the Forest and Greenhouse Planting of Dendrobium huoshanense

Frontiers in Plant Science, 2022
The highly esteemed Chinese herb, Dendrobium huoshanense, whose major metabolites are polysaccharides and alkaloids, is on the verge of extinction. The stone planting under the forest (SPUF) and greenhouse planting (GP) of D.
Liping Wu, Xiaoxi Meng, Huizhen Huang, Yingying Liu, Weimin Jiang, Xinglong Su, Zhaojian Wang, Fei Meng, Longhai Wang, Daiyin Peng, Daiyin Peng, Daiyin Peng, Shihai Xing, Shihai Xing, Shihai Xing   +14 more
doaj   +1 more source

Systems Biology of Recombinant 2G12 and 353/11 mAb Production in CHO-K1 Cell Lines at Phosphoproteome Level

Proteomes
Background: Chinese hamster ovary (CHO) cells are extensively used in the pharmaceutical industry for producing complex proteins, primarily because of their ability to perform human-like post-translational modifications.
Eldi Sulaj, Felix L. Sandell, Linda Schwaigerlehner, Gorji Marzban, Juliane C. Dohm, Renate Kunert   +5 more
doaj   +1 more source

Regulation of yeast central metabolism by enzyme phosphorylation

Molecular Systems Biology, 2012
As a frequent post‐translational modification, protein phosphorylation regulates many cellular processes. Although several hundred phosphorylation sites have been mapped to metabolic enzymes in Saccharomyces cerevisiae, functionality was demonstrated for
Ana Paula Oliveira, Christina Ludwig, Paola Picotti, Maria Kogadeeva, Ruedi Aebersold, Uwe Sauer   +5 more
doaj   +1 more source

Cross-Species Analysis of ABA-Induced Phosphosignaling Landscapes in Rice, Soybean, and Arabidopsis

Proteomes
Background: Abscisic acid (ABA) is a key phytohormone that regulates plant growth and stress responses through protein phosphorylation. While ABA-induced phosphosignaling has been extensively studied in Arabidopsis thaliana, its conservation and ...
Hinano Takase, Sotaro Katagiri, Takuma Ide, Aina Nagano, Haruki Sakurai, Hana Kokubo, Taiki Yanagisawa, Masanori Okamoto, Taishi Umezawa   +8 more
doaj   +1 more source

Kinase activities in pancreatic ductal adenocarcinoma with prognostic and therapeutic avenues

Molecular Oncology
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a limited number of known driver mutations but considerable cancer cell heterogeneity.
Andrea Vallés‐Martí, Richard R. deGoeij‐de Haas, Alex A. Henneman, Sander R. Piersma, Thang V. Pham, Jaco C. Knol, Joanne Verheij, Frederike Dijk, Hans Halfwerk, Elisa Giovannetti, Connie R. Jiménez, Maarten F. Bijlsma   +11 more
doaj   +1 more source