Results 41 to 50 of about 20,263 (273)
The Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells
Frontiers in Microbiology, 2021 Clostridioides difficile is a major cause of nosocomial infection worldwide causing antibiotic-associated diarrhea and some cases are leading to pseudomembranous colitis. The main virulence factors are toxin A and toxin B.
Florian Stieglitz +4 more
doaj +1 more source
Phosphoproteomics‐based network medicine [PDF]
The FEBS Journal, 2013 One of the major tasks of phosphoproteomics is providing potential biomarkers for either diagnosis or drug targets in medical applications. Because most complex diseases are due to the actions of multiple genes/proteins, the identification of complex phospho‐signatures containing multiple phosphorylation events within phosphoproteomics‐based networks ...
Zexian, Liu, Yongbo, Wang, Yu, Xue
openaire +2 more sources
An evolutionary perspective on the kinome of malaria parasites [PDF]
, 2012 Malaria parasites belong to an ancient lineage that diverged very early from the main branch of eukaryotes. The approximately 90-member plasmodial kinome includes a majority of eukaryotic protein kinases that clearly cluster within the AGC, CMGC, TKL ...
Andrew B. Tobin +6 more
core +1 more source
mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes
Cell Reports, 2016 FGF21 improves the metabolic profile of obese animals through its actions on adipocytes. To elucidate the signaling network responsible for mediating these effects, we quantified dynamic changes in the adipocyte phosphoproteome following acute exposure ...
Annabel Y. Minard +9 more
doaj +1 more source
Phosphoproteomics taken to heart [PDF]
Cell Cycle, 2013 The last decade has witnessed a tremendous advance in mass spectrometric instrumentation, sample preparation, and computational proteomics developments that now make it possible to analyze proteins1 or post-translational modifications (PTMs) of proteins2 on a global scale and compare their relative abundance between different cell states.
Lundby, A., Olsen, J.V.
openaire +3 more sources
HIV-1 Activates T Cell Signaling Independently of Antigen to Drive Viral Spread [PDF]
, 2016 open access articleHIV-1 spreads between CD4 T cells most efficiently through virus-induced cell-cell contacts. To test whether this process potentiates viral spread by activating signaling pathways, we developed an approach to analyze the ...
Jolly, Clare +3 more
core +2 more sources
Frontiers in Microbiology, 2018 The large clostridial glucosylating toxin B (TcdB) is a major virulence factor of the nosocomial pathogen Clostridioides difficile. TcdB inhibits small GTPases by glucosylation leading to impaired downstream signaling.
Johannes Junemann +3 more
doaj +1 more source
Molecular Oncology, 2010 AbstractReversible protein phosphorylation serves as a basis for regulating a number of cellular processes. Aberrant activation of kinase signaling pathways is commonly associated with several cancers. Recent developments in phosphoprotein/phosphopeptide enrichment strategies and quantitative mass spectrometry have resulted in robust pipelines for high‐
H C, Harsha, Akhilesh, Pandey
openaire +3 more sources
Supplementary Figure 3 from Global Quantitative Phosphoproteome Analysis of Human Tumor Xenografts Treated with a CD44 Antagonist [PDF]
, 2023 Stefan Weigand +7 more
openalex +2 more sources
Large‐scale phosphorylation mapping reveals the extent of tyrosine phosphorylation in Arabidopsis
Molecular Systems Biology, 2008 Protein phosphorylation regulates a wide range of cellular processes. Here, we report the proteome‐wide mapping of in vivo phosphorylation sites in Arabidopsis by using complementary phosphopeptide enrichment techniques coupled with high‐accuracy mass ...
Naoyuki Sugiyama +6 more
doaj +1 more source