Results 41 to 50 of about 12,382 (182)

Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks [PDF]

, 2014
The focus of the present study was to characterize the phosphoproteome of cytotoxic T cells and to explore the role of the serine threonine kinase PKD2 (Protein Kinase D2) in the phosphorylation networks of this key lymphocyte population.
Goebel, Juergen, Hukelmann, Jens L., Cantrell, Doreen A., Navarro, Maria N.   +3 more
core   +1 more source

Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells

Frontiers in Microbiology, 2018
The large clostridial glucosylating toxin B (TcdB) is a major virulence factor of the nosocomial pathogen Clostridioides difficile. TcdB inhibits small GTPases by glucosylation leading to impaired downstream signaling.
Johannes Junemann, Ingo Just, Ralf Gerhard, Andreas Pich   +3 more
doaj   +1 more source

Large‐scale phosphorylation mapping reveals the extent of tyrosine phosphorylation in Arabidopsis

Molecular Systems Biology, 2008
Protein phosphorylation regulates a wide range of cellular processes. Here, we report the proteome‐wide mapping of in vivo phosphorylation sites in Arabidopsis by using complementary phosphopeptide enrichment techniques coupled with high‐accuracy mass ...
Naoyuki Sugiyama, Hirofumi Nakagami, Keiichi Mochida, Arsalan Daudi, Masaru Tomita, Ken Shirasu, Yasushi Ishihama   +6 more
doaj   +1 more source

Induction of Macrophage Function in Human THP-1 Cells is Associated with MAPK Signaling and Activation of MAP3K7 (TAK1) Protein Kinase

Frontiers in Cell and Developmental Biology, 2016
Macrophages represent the primary human host response to pathogen infection and link the immediate defense to the adaptive immune system. Mature tissue macrophages convert from circulating monocyte precursor cells by terminal differentiation in a process
Erik eRichter, Katharina eVentz, Manuela eHarms, Joerg eMostertz, Falko eHochgräfe   +4 more
doaj   +1 more source

Proteomics Analysis of Duck Lung Tissues in Response to Highly Pathogenic Avian Influenza Virus

Microorganisms
Domestic ducks (Anas platyrhynchos domesticus) are resistant to most of the highly pathogenic avian influenza virus (HPAIV) infections. In this study, we characterized the lung proteome and phosphoproteome of ducks infected with the HPAI H5N1 virus (A ...
Periyasamy Vijayakumar, Anamika Mishra, Ram Pratim Deka, Sneha M. Pinto, Yashwanth Subbannayya, Richa Sood, Thottethodi Subrahmanya Keshava Prasad, Ashwin Ashok Raut   +7 more
doaj   +1 more source

Development of phosphopeptide enrichment techniques for phosphoproteome analysis

, 2008
Protein phosphorylation is one of the most biologically relevant and ubiquitous post-translational modifications. The analysis of protein phosphorylation is very challenging due to its highly dynamic nature and low stoichiometry.
Han, Guanghui, Zou, Hanfa, 邹汉法, Ye, Mingliang   +3 more
core   +1 more source

The Mitogen‐Activated Protein Kinase GhNTF3 Modulates the Arbuscular Mycorrhizal Symbiosis‐Immunity Trade‐Off in Cotton by Regulating Salicylic Acid Biosynthesis

Advanced Science, EarlyView.
AM symbiosis induces GhWAK13 to promote fungal colonization. GhNTF3 negatively regulates symbiosis by promoting SA biosynthesis. GhWAK13 sequesters GhNTF3 at the membrane, limiting its nuclear translocation and relieving SA‐mediated suppression. Under Verticillium stress, GhNTF3 enters the nucleus and interacts with GhJAZ6 to activate SA signaling ...
Shuangjie Jia, Jingshang Wen, Jihang Li, Meina Feng, Yiming He, Ruojun Liu, Qian Liu, Junli Zhang, Kai Cheng, Xiangyu Zhang, Xiao Zhang   +10 more
wiley   +1 more source

Global Phosphoproteomics Analysis of IBRS-2 Cells Infected With Senecavirus A

Frontiers in Microbiology, 2022
Phosphorylation is a widespread posttranslational modification that regulates numerous biological processes. Viruses can alter the physiological activities of host cells to promote virus particle replication, and manipulating phosphorylation is one of ...
Jieyi Li, Zhongwang Zhang, Zhongwang Zhang, Jianliang Lv, Jianliang Lv, Zhongyuan Ma, Li Pan, Li Pan, Yongguang Zhang, Yongguang Zhang   +9 more
doaj   +1 more source

CaMKIIδ Phosphorylates AUP1 to Promote Pancreatic Tissue Repair and Acinar‐to‐Ductal Metaplasia Formation via Mediating PERK‐Dependent Unfolded Protein Responses

Advanced Science, EarlyView.
CaMKIIδ–AUP1 signaling maintains PERK‐dependent ER homeostasis during ADM‐mediated pancreatic repair. ABSTRACT Pancreatic repair after acute pancreatitis (AP) is essential for restoring tissue integrity, but the intrinsic mechanisms coordinating acinar plasticity and regeneration remain poorly understood.
Yonghao Chen, Ziying Han, Zihan Yang, Jie Wu, Kaixin Peng, Xiuli Zhang, Bintao Qiu, Jianqiang Wu, Xiaomin Hu, Dong Wu, Li Wen   +10 more
wiley   +1 more source

An Unbiased Approach to Mapping the Signaling Network of the Pseudorabies Virus US3 Protein

Pathogens, 2020
The US3 serine/threonine protein kinase is conserved among the alphaherpesvirus family and represents an important virulence factor. US3 plays a role in viral nuclear egress, induces dramatic alterations of the cytoskeleton, represses apoptosis, enhances
Robert J. J. Jansens, Sandra Marmiroli, Herman W. Favoreel   +2 more
doaj   +1 more source