Results 51 to 60 of about 12,382 (182)
Open Biology, 2021 Fluctuations in TOR, AMPK and MAP-kinase signalling maintain cellular homeostasis and coordinate growth and division with environmental context. We have applied quantitative, SILAC mass spectrometry to map TOR and nutrient-controlled signalling in the ...
Lenka Halova +10 more
doaj +1 more source
Angewandte Chemie, EarlyView.Um außergewöhnlich wirksame Wirkstoffe zu entwickeln, ist es erforderlich, über die Bindungsstelle hinaus zu denken. Diese Arbeit zeigt, dass die auf den ersten Blick kontraintuitive Adressierung einer konservierten Region der Kinase zu einer hochselektiven Bindung führen kann.
Nico J. Seidler +20 more
wiley +1 more source
Two-dimensional gel electrophoresis approach for CTL phosphoproteome analysis.
, 2014 Phosphorylation of proteins plays a pivotal role in signal transduction processes, and it is a key regulator of many biological cell functions. Various strategies have been proposed for the study of phosphoproteome; most of them require a multi-step ...
Rocchetti M. T. +8 more
core +1 more source
Angewandte Chemie International Edition, EarlyView.To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler +20 more
wiley +1 more source
iMetaMed, EarlyView.We presented an organ‐resolved, multiple PTM remodeling atlas of systemic T. marneffei infection, integrating quantitative proteome, phosphoproteome, ubiquitinome, acetylome, and lactylome data across the liver, lung, and spleen. The atlas delineated organ‐specific PTM signatures and a functional convergence of divergent modification types on immune ...
Wudi Wei +16 more
wiley +1 more source
, 2023 List of the differentially phosphorylated proteins involved in tachyzoite division as revealed by phosphoproteome analysis.
Qin-Li Liang (5689277) +9 more
core +1 more source
Interdisciplinary Medicine, EarlyView.This review outlines specific peptide enrichment strategies, including metal, magnetic oxides, functional polymers, and antibody‐based approaches, and their mechanisms, highlighting applications in biomarker discovery for major neurological and psychiatric disorders.
Xue Zhang +8 more
wiley +1 more source
Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles
Mass Spectrometry Reviews, EarlyView.ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág +5 more
wiley +1 more source
Precision Radiation Oncology, EarlyView.This study underscores the critical role of PTMs in mediating cellular responses to X‐ray and Carbon ion irradiation radiotherapy in HNSCC. The integration of multi‐omics data provides insights into the molecular mechanisms underlying radiation‐induced changes, offering valuable clues for improving therapeutic outcomes and advancing precision medicine ...
Fan‐Tong Xia +13 more
wiley +1 more source
The developmental phosphoproteome of Haemonchus contortus
, 2020 Protein phosphorylation plays essential roles in many cellular processes. Despite recent progress in the genomics, transcriptomics and proteomics of socioeconomically important parasitic nematodes, there is scant phosphoproteomic data to underpin ...
Korhonen, PK +9 more
core +1 more source