Results 61 to 70 of about 12,382 (182)
Andrology, EarlyView.ABSTRACT Background Sperm cryopreservation causes cryodamage, but the roles of posttranslational modifications (PTMs) and stress granules (SGs) in this process remain unclear. Objectives To investigate the molecular mechanism of cryodamage via the TRIM21–AKAP3 axis, PTMs, and SGs.
Yan Wang +9 more
wiley +1 more source
Quest for the Crypto-phosphoproteome
, 2021 Protein phosphorylation is one of the most studied post???translational modifications (PTMs). Despite the remarkable advances in phosphoproteomics, a chemically less???stable subset of the phosphosites, which we call the crypto???phosphoproteome, has ...
Hoyoung Jung +5 more
core +1 more source
PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes
British Journal of Pharmacology, EarlyView.Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier +9 more
wiley +1 more source
A guide to laser microdissection‐based proteomics
The FEBS Journal, EarlyView.This review takes researchers through the full laser microdissection proteomics workflow—from tissue preparation and image analysis to sample processing and mass spectrometry—offering practical solutions to common challenges at each step. Real‐world examples from across the field illustrate how the technology is being applied to disease tissue, making ...
Cheng Shen +3 more
wiley +1 more source
Outline of the experimental workflow for phosphoproteome profiling of TGFβ1 signaling.
, 2013 Outline of the experimental workflow for phosphoproteome profiling of TGFβ1 signaling.
Monica Cojoc (417190) +3 more
core +1 more source
Phosphorylation of BigH1 regulates its expression pattern and promotes embryonic development
The FEBS Journal, EarlyView.Phosphorylation is a key regulator of the linker histone variant BigH1 during Drosophila embryogenesis. We reveal that N‐terminal phosphorylation promotes the timely removal of BigH1 from chromatin. In contrast, C‐terminal phosphorylation supports early nuclear divisions and embryonic viability.
Ramóna Pék +9 more
wiley +1 more source
SMSNet's predictions for HLA peptidome and human phosphoproteome datasets
, 2019 SMSNet's predicted amino acid sequences for a public HLA peptidome dataset (MassIVE accession MSV000080527) and human phosphoproteome dataset (PRIDE accession PXD009227).
Sira Sriswasdi (6695909)
core +1 more source
New Phytologist, EarlyView.Multiple facets of Chlorella ohadii biological properties and potential as a research model and biotechnology platform. Summary Since its isolation from the sand dunes of the Negev Desert over a decade ago, the unicellular green alga Chlorella ohadii has turned into a reference organism for studying photosynthesis, metabolism, and abiotic stress ...
Or Geffen +4 more
wiley +1 more source
An AGC kinase cascade regulates ROP signaling for the correct timing of pollen germination
New Phytologist, EarlyView.Model for PDK1‐AGC1.5/7 kinase cascade function in controlling pollen germination. Summary In flowering plants, the timing of pollen germination is crucial for successful fertilization and an important trait for seed and fruit crops. Environmental factors tightly regulate pollen germination, with germination‐suppressing conditions on the pollen ...
Tong Zhao +10 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 21, 12 November 2026.Can a single element help address the multifactorial nature of ALS? Boron‐containing compounds combine responsiveness to reactive oxygen species (ROS), neuroprotective activity, and favorable pharmacological properties, offering a distinctive framework for disease modification in a complex disease like ALS.
Nitesh Sanghai +5 more
wiley +1 more source