Results 81 to 90 of about 20,263 (273)

Reprogramming of cardiac phosphoproteome, proteome, and transcriptome confers resilience to chronic adenylyl cyclase-driven stress

eLife
Our prior study (Tarasov et al., 2022) discovered that numerous adaptive mechanisms emerge in response to cardiac-specific overexpression of adenylyl cyclase type 8 (TGAC8) which included overexpression of a large number of proteins.
Jia-Hua Qu, Khalid Chakir, Kirill V Tarasov, Daniel R Riordon, Maria Grazia Perino, Allwin Jennifa Silvester, Edward G Lakatta   +6 more
doaj   +1 more source

Fully Tunable Phosphorylation of RPS6A Ensures the Successful Development of Arabidopsis Seedlings

Plant, Cell &Environment, Volume 49, Issue 5, Page 2783-2794, May 2026.
ABSTRACT Light enhances protein translation, enabling young seedlings to rapidly and timely acquire photosynthetic capacities. Sequential phosphorylation of ribosomal protein S6 (RPS6) was implicated in the light‐enhanced translation; however, the exact phosphorylation sites and the biological relevance of RPS6 multi‐phosphorylation in seedling ...
Yueh Cho, Guan‐Hong Chen, Shu‐Hsing Wu   +2 more
wiley   +1 more source

PhosFox : a bioinformatics tool for peptide-level processing of LC-MS/MS-based phosphoproteomic data [PDF]

, 2014
Peer ...
Aittokallio, Tero, Hintsanen, Petteri, Nyman, Tuula A., Ohman, Tiina, Söderholm, Sandra   +4 more
core   +1 more source

Tracking tau and cellular responses in human iPSC‐microglia: from uptake to seedable secretion, including in extracellular vesicles

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Microglia have been implicated in the templated spread of tau aggregates in tauopathies through mouse studies. However, it is unclear whether these findings translate to human disease. METHODS We challenged human induced pluripotent stem cell (iPSC)‐derived microglia‐like‐cells (iMGL) with monomeric and fibrillar recombinant tau ...
Maria Kreger Karabova, Anna del Ser‐Badia, Anne Hedegaard, Sam J. Washer, Zeynep Baykam, Darragh P. O'Brien, Iolanda Vendrell, Svenja S. Hester, Roman Fischer, Errin Johnson, Charlotte E. Melia, Teige R. S. Matthews‐Palmer, Rishi Matadeen, Alessia Santambrogio, Michael A. Metrick II, Michele Vendruscolo, Sophie Keeling, Kimberly Ai Xian Cheam, William A. McEwan, Kenneth S. Kosik, Theresa A. Day, William S. James, Sally A. Cowley   +22 more
wiley   +1 more source

The dynamic organization of fungal acetyl-CoA carboxylase [PDF]

, 2016
Acetyl-CoA carboxylases (ACCs) catalyse the committed step in fatty-acid biosynthesis: the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. They are important regulatory hubs for metabolic control and relevant drug targets for the treatment of ...
Hagmann, Anna, Hunkeler, Moritz, Imseng, Stefan, Maier, Timm, Stuttfeld, Edward   +4 more
core   +1 more source

Hepatic‐Differentiated Subpopulation in Clear Cell Renal Cell Carcinoma: A Multi‐Omics Analysis of Tumors With Lymphovascular Invasion

Cancer Medicine, Volume 15, Issue 4, April 2026.
A hepatic‐differentiated subpopulation is associated with lymphovascular invasion in clear cell renal cell carcinoma. A visual summary of the key findings from our multi‐omics analysis. The TITANIA framework enabled the identification of a hepatic‐differentiated ccRCC subpopulation characterized by the upregulation of liver‐like metabolic pathways and ...
Shugo Yajima, Yuichiro Tsukada, Riu Yamashita, Takao Fujisawa, Takeshi Kuwata, Reiko Watanabe, Genichiro Ishii, Nina Gabelia, Hartmut Juhl, Yoshikatsu Koga, Takayuki Yoshino, Masaaki Ito, Hitoshi Masuda   +12 more
wiley   +1 more source

Quantitative phosphoproteome analysis of embryonic stem cell differentiation toward blood [PDF]

, 2015
Murine embryonic stem (ES) cells can differentiate in vitro into three germ layers (endodermic, mesodermic, ectodermic). Studies on the differentiation of these cells to specific early differentiation stages has been aided by an ES cell line carrying the
Cocco, Lucio, Kouskoff, Valerie, Lacaud, Georges, Lee, Chia-Fang, McCubrey, James A., NC DOCKS at East Carolina University, Pearson, Stella, Piazzi, Manuela, Whetton, Anthony D., Williamson, Andrew   +9 more
core   +2 more sources

Phosphoproteome Profiling of Mouse Liver During Normal Aging [PDF]

, 2021
Jiangfeng Liu, Yue Wu, Ye-Hong Yang, Songfeng Wu, Shu Liu, Ping Xu, Juntao Yang   +6 more
openalex   +1 more source

PRKD3 Overexpression May Improve Survival and Suppresses Proliferation in Colorectal Cancer

Cancer Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Objective The study aimed to explore PRKD3 protein expression in colorectal cancer and its clinical implications. Methods PRKD3 expression was assessed in 189 paired colorectal cancer tissues and their corresponding adjacent non‐cancerous counterparts using tissue microarray‐based immunohistochemistry. The associations of PRKD3 expression with
Bin Zhang, Chen Chang, Jingli Chen, Yue Cao, Yu Chang, Lele Liu, Wensheng Li, Guorong Wang   +7 more
wiley   +1 more source

Phosphoproteomics Illuminates Opioid Actions

Biochemistry, 2018
Opioids are widely used analgesic medications with a high potential for tolerance and dependence and represent a frequent cause of death due to overdose. Opioids mediate their actions via a family of opioid G protein coupled receptors. Elucidating the biochemical mechanism(s) responsible for both the therapeutic and deleterious side effects of opioids ...
Tao Che, Bryan L. Roth
openaire   +3 more sources