Results 81 to 90 of about 73,329 (379)

Phospho.ELM:a database of experimentally verified phosphorylation sites in eukaryotic proteins [PDF]

, 2004
BACKGROUND: Post-translational phosphorylation is one of the most common protein modifications. Phosphoserine, threonine and tyrosine residues play critical roles in the regulation of many cellular processes.
Blom, Nikolaj, Cameron, Scott, Diella, Francesca, Gemünd, Christine, Gibson, Toby J., Kuster, Bernhard, Linding, Rune, Sicheritz-Pontén, Thomas, Via, Allegra   +8 more
core   +4 more sources

Visualization of the Phosphoproteomic Data from AfCS with the Google Motion Chart Gadget [PDF]

, 2009
Results from multivariate molecular biological experiments become increasingly complex. Hence, the challenge of projecting high-dimensional data onto few dimensions for effective data visualization is becoming increasingly important in Systems Biology ...
Avi Ma', Huilei Xu
core   +1 more source

Cytokine-associated drug toxicity in human hepatocytes is associated signaling network dysregulation [PDF]

, 2009
Refer to Web version on PubMed Central for supplementary material.Idiosyncratic drug hepatotoxicity is a major problem in pharmaceutical development due to poor prediction capability of standard preclinical toxicity assessments and limited knowledge of ...
Ballif, Bart S. Hendriks, Benjamin D. Cosgrove, Bylesjö, Chokki, Clayton, Cosgrove, Cosgrove, Deng, Deng, Deng, Douglas A. Lauffenburger, Fielden, Ganey, Gaudet, Geladi, Gunawan, Hatano, Hotamisligil, Janes, Janes, Janes, Janes, Kaplowitz, Kaplowitz, Kemp, Kim, Kolls, Kumar, Kumar, Le, Lee, Leonidas G. Alexopoulos, Linda G. Griffith, Malhi, McCubrey, Miller-Jensen, Ono, Peter K. Sorger, Saez-Rodriguez, Sarbassov, Schwabe, Shaw, Ta-chun Hang, Tacke, Tukov, Wajant, Wold, Xu, Xu, Yuan   +50 more
core   +1 more source

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells.

PLoS ONE, 2008
Hematopoietic stem cells (HSCs) are probably the best-studied adult tissue-restricted stem cells. Although methods for flow cytometric detection of phosphoproteins in hematopoeitic progenitors and mature cells are available, analogous protocols for HSC ...
Demetrios Kalaitzidis, Benjamin G Neel
doaj   +1 more source

iTRAQ-Based Phosphoproteomic Analysis of Toxoplasma gondii Tachyzoites Provides Insight Into the Role of Phosphorylation for its Invasion and Egress

Frontiers in Cellular and Infection Microbiology, 2020
The invasion and egress are two key steps in lytic cycle vital to the propagation of Toxoplasma gondii infection, and phosphorylation is believed to play important roles in these processes. However, the phosphoproteome of T.
Cheng He, Mei-zhen Xu, Shuai Pan, Hui Wang, Hong-juan Peng, Zhuan-zhuan Liu   +5 more
doaj   +1 more source

Quantitative and functional post-translational modification proteomics reveals that TREPH1 plays a role in plant thigmomorphogenesis

, 2018
Plants can sense both intracellular and extracellular mechanical forces and can respond through morphological changes. The signaling components responsible for mechanotransduction of the touch response are largely unknown.
Braam, Janet, Chehab, E. Wassim, Dai, Chen, Li, Ning, Liu, Jun, Liu, Shichang, Qing, Dongjin, Ren, Feng, Wang, Kai, Wu, Madeline, Yang, Zhu, Zhang, Weiping, Zheng, Qingsong   +12 more
core   +2 more sources

Metformin suppresses lung adenocarcinoma by downregulating long non-coding RNA (lncRNA) AFAP1-AS1 and secreted phosphoprotein 1 (SPP1) while upregulating miR-3163 [PDF]

, 2022
Caiyu Qiu, Chuanxiang Li, Quan Zheng, Fang Si, Jianqun Xu, Hongjuan Wang, Hongrong Guo   +6 more
openalex   +1 more source

Cholesterol‐DNA Origami Nanostructures for Synthetic Lipid Rafts Induce Early T Cell Activation Signals

Advanced Materials Interfaces, EarlyView.
Here, we present a nanotechnology approach to construct synthetic lipid rafts on the live T cell membrane, leveraging a versatile DNA origami‐enabled platform named as the “cholesterol nano‐patch” (CNP). Our investigation highlights the effectiveness of DNA nanotechnology in exploring the impact of nanoscale arrangement of cholesterols on the ...
Yunmin Jung, Young‐Joo Kim, Kunwoo Noh, Sunmi Lee, Minsuk Kwak   +4 more
wiley   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source