Results 91 to 100 of about 37,055 (269)

Treatment‐Driven Peripheral Blood Transcriptomic Remodeling and Baseline Predictors of ESSDAI and STAR Response to B Cell Therapy in Sjögren's Disease

Arthritis &Rheumatology, EarlyView.
Graphical Abstract Objective This study aimed to characterize whole blood transcriptomic profiles in adults with active Sjögren's disease (SjD) treated with anti‐CD20 or B lymphocyte stimulator/BAFF inhibition, identify markers of clinical response, and define inflammatory pathways linked to nonresponse. Methods Whole blood RNA sequencing was performed
Aimen Ibrahim, Junjie Peng, Eileen Tian, Lucia Martin‐Gutierrez, John Casement, Kyle Thompson, Wan‐Fai Ng, André van Maurik, Elizabeth C. Jury, Coziana Ciurtin   +9 more
wiley   +1 more source

Role of post-translational phosphorylation on post-slaughter meat quality differences between cattle-yak and yak longissimus thoracis

Journal of Future Foods
We used tandem mass tag proteomics to explore and compare phosphoprotein profiles and the mechanisms underlying protein phosphorylation regulation in cattle-yak longissimus thoracis (CYLT) and yak longissimus thoracis (YLT).
Xinping Chang, Zhendong Liu, Zhang Luo, Xuedong Gu, Jinqiu Wang, Fang Geng   +5 more
doaj   +1 more source

Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells.

PLoS ONE, 2008
Hematopoietic stem cells (HSCs) are probably the best-studied adult tissue-restricted stem cells. Although methods for flow cytometric detection of phosphoproteins in hematopoeitic progenitors and mature cells are available, analogous protocols for HSC ...
Demetrios Kalaitzidis, Benjamin G Neel
doaj   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Optimized micro‐sized cell sphere‐matrix niche co‐aggregates promote efficient oral and craniomaxillofacial bone regeneration

BMEMat, EarlyView.
The construct of cell‐niche co‐aggregates (GelMA‐SHED sphere‐DDMPs) promotes cranial and periodontal bone regeneration and ensures angiogenic‐osteogenic coupling by downregulating miR‐34c‐5p to enhance the expression of NOTCH1 and its intracellular domain (NICD).
Xiao‐Hui Zhang, Shi‐Han Mu, Yi‐Han Xiao, Lu‐Fan Yang, Peng‐Fei Wang, Teng‐Fei Hu, Jun‐Xi He, Jiong‐Zhen Piao, Sha Zhang, Jin‐Yu Liu, Yi‐De He, Ying‐Ying Wu, Si‐Qi Ying, Xin‐Yue Cai, Chen‐Han Li, Zi‐Qi Zhang, Xiao Lei, Ji Chen, Jian‐Fei Liang, Yan Jin, Bing‐Dong Sui, Chao Ma, Chen‐Xi Zheng, Fang Jin   +23 more
wiley   +1 more source

TiO2 NPs@UiO-66 TiZr dual active centers demonstrate excellent performance in phosphoprotein detection in sweat

Sensing and Bio-Sensing Research
Protein phosphorylation in sweat metabolites plays a key role in nerve activity, muscle contraction, and other activities, and abnormal protein phosphorylation may lead to diseases such as neurodegenerative disorders. Real-time non-invasive monitoring of
Ce Bian, Xiang Guan, Zhi Jia, Yu Tang, Peng Zhang, Bingxin Liu, Li Gao, Lijuan Qiao   +7 more
doaj   +1 more source

Function classifications of identified metabolism-related proteins (A) and phosphoproteins (B).

, 2014
Function classifications of identified metabolism-related proteins (A) and phosphoproteins (B).
Zhixing Zhang (219430), Jun Tang (32983), Dongmei Chen (124974), Zhong Li (324520), Zhou Li (140418), Wenxiong Lin (219445), Hong Zhao (325)   +6 more
core   +1 more source

Multiscale Modeling of an 8‐Week Combination Regimen of Bemnifosbuvir and Ruzasvir in Patients with Chronic Hepatitis C Virus Infection

Clinical Pharmacology &Therapeutics, EarlyView.
Bemnifosbuvir (BEM) and ruzasvir (RZR) are pan‐genotypic HCV polymerase (NS5B) and NS5A inhibitors, respectively. In a single‐arm study (NCT05904470), 215 treatment‐naïve, adherent participants with chronic HCV (with or without cirrhosis) received BEM 550 mg QD plus RZR 180 mg QD for 8 weeks.
Carolin Zitzmann, Ruy M. Ribeiro, Aurelien Marc, Xiao‐Jian Zhou, Alan S. Perelson   +4 more
wiley   +1 more source

Significantly enriched Kyoto Encyclopedia of Genes and Genomes pathways of the identified phosphoproteins in jejunum tissue.

, 2022
Significantly enriched Kyoto Encyclopedia of Genes and Genomes pathways of the identified phosphoproteins in jejunum tissue.
Xiaowei Zhao (10501319)
core   +1 more source

Dental development in the tropical gar (Atractosteus tropicus) and the evolution of vertebrate dentitions

Developmental Dynamics, EarlyView.
Abstract Background Dentitions have diversified enormously during vertebrate evolution, involving reductions, modifications, or allocations to prey seizing and processing regions. A combination of ancient and novel features related to dental and oropharyngeal apparatuses is found in extant lineages of non‐teleost fishes, such as the gars.
Anna Pospisilova, Jan Stundl, Lenin Arias‐Rodriguez, Robert Cerny, Vladimír Soukup   +4 more
wiley   +1 more source