Results 81 to 90 of about 31,335 (237)
Frontiers in Plant Science, 2014 Mitogen-activated protein kinases (MAPKs) target a variety of protein substrates to regulate cellular signaling processes in eukaryotes. In plants, the number of identified MAPK substrates that control plant defense responses is still limited.
Ines eLassowskat +5 more
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Quantitative phosphoproteomics of proteasome inhibition in multiple myeloma cells.
PLoS ONE, 2010 The proteasome inhibitor bortezomib represents an important advance in the treatment of multiple myeloma (MM). Bortezomib inhibits the activity of the 26S proteasome and induces cell death in a variety of tumor cells; however, the mechanism of ...
Feng Ge +9 more
doaj +1 more source
Cancer Management and Research, 2020 Xincong Lin,1,2,* Yao Huang,1,2,* Ying Sun,2 Xionghong Tan,2 Jiahe Ouyang,2 Bixing Zhao,2 Yingchao Wang,2 Xiaohua Xing,1,2 Jingfeng Liu1,2 1The First Affiliated Hospital of Fujian Medical University, Fuzhou 350007, People’s Republic of China; 2The United
Lin X +8 more
doaj
Majorbio Cloud 2026 Update: An End‐to‐End Solution for Proteomics Research
iMetaMed, EarlyView.The recent upgrade of Majorbio Cloud facilitates a more streamlined and accurate research process, aiding researchers across the various proteomics subfields. Furthermore, it propels the advancement of multi‐layered, multi‐omics scientific investigations centered around proteins.
Caiping Shi +17 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.Inspired by the role of Mg2+ in stabilizing RNA secondary structures, we developed a one‐pot biomimetic mineralization method for synthesizing a circular RNA‐based nanovaccine (circRNA@FAiNVac) that integrates formulation and adjuvant functions. This nanovaccine exhibits potent immunostimulatory activation enabling multimodal immune responses and ...
Liangru Lin +10 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu +6 more
wiley +1 more source
Experiencing 50 Years of Synergistic Development in Structural Biology and Enzymology
Journal of the Chinese Chemical Society, EarlyView.Picture of Sunney Chan with Academia Sinica (AS) President James C. Liao and three Vice Presidents: Shin‐Kun Peng (left one), Tang K. Tang (right one), and Mei‐Yin Chou (right 2), taken at the annual Chinese New Year's Banquet of AS, February 7, 2025. This was likely Sunney's last appearance in formal activities of AS.
Ming‐Daw Tsai
wiley +1 more source
Ion Activation Methods for Top‐Down Proteomics
Mass Spectrometry Reviews, EarlyView.ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley +1 more source
Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles
Mass Spectrometry Reviews, EarlyView.ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág +5 more
wiley +1 more source