Results 111 to 120 of about 20,263 (273)

Data from Computational Analysis of Cholangiocarcinoma Phosphoproteomes Identifies Patient-Specific Drug Targets

, 2023
Shirin Elizabeth Khorsandi, Arran Dokal, Vinothini Rajeeve, David J. Britton, Megan S. Illingworth, Nigel Heaton, Pedro R. Cutillas   +6 more
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Mapping the phosphoproteome of influenza A and B viruses by mass spectrometry [PDF]

, 2012
Protein phosphorylation is a common post-translational modification in eukaryotic cells and has a wide range of functional effects. Here, we used mass spectrometry to search for phosphorylated residues in all the proteins of influenza A and B viruses ...
Denham, Eleanor M., Fodor, Ervin, Hester, Svenja S., Hutchinson, Edward C., Ridlova, Gabriela, Thomas, Benjamin, Trudgian, David C., Turrell, Lauren, York, Ashley   +8 more
core   +3 more sources

Mass spectrometry-based proteomic exploration of the human immune system : focus on the inflammasome, global protein secretion, and T cells [PDF]

, 2017
Introduction: The immune system is our defense system against microbial infections and tissue injury, and understanding how it works in detail is essential for developing drugs for different diseases.
Cypryk, Wojciech, Lorey, Martina B., Matikainen, Sampsa, Nyman, Tuula A.   +3 more
core   +1 more source

Fast and Deep Phosphoproteome Analysis with the Orbitrap Astral Mass Spectrometer [PDF]

, 2023
Noah M. Lancaster, Pavel Sinitcyn, Patrick Forny, Trenton M. Peters-Clarke, Caroline Fecher, Andrew J. H. Smith, Evgenia Shishkova, Tabiwang N. Arrey, Anna Pashkova, Margaret Lea Robinson, Nicholas L. Arp, Jing Fan, J N Hansen, Andrea Galmozzi, Lia R. Serrano, Julie Rojas, Audrey P. Gasch, Michael S. Westphall, Hamish Stewart, Christian Hock, Eugen Damoc, David J. Pagliarini, Vlad Zabrouskov, Joshua J. Coon   +23 more
openalex   +1 more source

Large-scale phosphoproteome analysis in seedling leaves of Brachypodium distachyon L. [PDF]

, 2014
BACKGROUND: Protein phosphorylation is one of the most important post-translational modifications involved in the regulation of plant growth and development as well as diverse stress response. As a member of the Poaceae, Brachypodium distachyon L.
Ai-Qin Gu, Chang Wang, Dong-Wen Lv, Ming Zhang, Shou-Min Zhen, Xiao-Hui Li, Xin Li, Yue-Ming Yan   +7 more
core   +1 more source

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling [PDF]

, 2010
September 21 Author ManuscriptThe mammalian target of rapamycin (mTOR) protein kinase is a master growth promoter that nucleates two complexes, mTORC1 and mTORC2. Despite the diverse processes controlled by mTOR, few substrates are known.
Cao, Coller, D. Lim, D. M. Sabatini, Dowling, Feldman, Holt, Huber, Hutti, J. A. Marto, J. Rameseder, K. A. Ottina, Laplante, M. B. Yaffe, Mok, Morrione, N. S. Gray, O'Reilly, P. P. Hsu, Parker, Pearce, Pearce, S. A. Kang, Shah, T. R. Peterson, Wan, Y. Choi, Y. Zhang, Yip, Zoncu   +29 more
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Kinase activities in pancreatic ductal adenocarcinoma with prognostic and therapeutic avenues

Molecular Oncology
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a limited number of known driver mutations but considerable cancer cell heterogeneity.
Andrea Vallés‐Martí, Richard R. deGoeij‐de Haas, Alex A. Henneman, Sander R. Piersma, Thang V. Pham, Jaco C. Knol, Joanne Verheij, Frederike Dijk, Hans Halfwerk, Elisa Giovannetti, Connie R. Jiménez, Maarten F. Bijlsma   +11 more
doaj   +1 more source

Cellular reprogramming through mitogen-activated protein kinases

Frontiers in Plant Science, 2015
Mitogen-activated protein kinase (MAPK) cascades are conserved eukaryote signaling modules where MAPKs, as the final kinases in the cascade, phosphorylate protein substrates to regulate cellular processes.
Justin eLee, Lennart eEschen-Lippold, Ines eLassowskat, Ines eLassowskat, Ines eLassowskat, Christoph eBoettcher, Christoph eBoettcher, Dierk eScheel   +7 more
doaj   +1 more source

Phosphoproteome analyses pinpoint the F‐box protein SLOW MOTION as a regulator of warm temperature‐mediated hypocotyl growth in Arabidopsis [PDF]

, 2023
Shanshuo Zhu, Lixia Pan, Lam Dai Vu, Xiangyu Xu, Beatriz Orosa‐Puente, Tingting Zhu, Pia Neyt, Brigitte van de Cotte, Thomas B. Jacobs, Joshua M. Gendron, Steven H. Spoel, Kris Gevaert, Ive De Smet   +12 more
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology
B‐cell chronic lymphocytic leukemia (B‐CLL) is characterized by highly heterogeneous genomic alterations and altered signaling pathways, with limited studies on its proteome. Our study presents a comprehensive analysis of the proteome and phosphoproteome
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
doaj   +1 more source