Results 21 to 30 of about 3,489 (142)

Alkaline Phosphatase: A Reliable Endogenous Partner for Drug Delivery and Diagnostics

Advanced Therapeutics, Volume 5, Issue 2, February 2022., 2022
Alkaline phosphatase has been an endogenous partner for phosphate prodrugs for decades. More recently, it has been utilized as a reliable partner for enzyme‐responsive drug nanocarriers and diagnostic systems constructed from novel phosphate‐functionalized biomaterials.
Bao Le‐Vinh, Zeynep Burcu Akkuş‐Dağdeviren, Nguyet‐Minh Nguyen Le, Imran Nazir, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Strategies of organic phosphorus recycling by soil bacteria: acquisition, metabolism, and regulation

Environmental Microbiology Reports, Volume 14, Issue 1, Page 3-24, February 2022., 2022
Summary Critical to meeting cellular phosphorus (P) demand, soil bacteria deploy a number of strategies to overcome limitation in inorganic P (Pi) in soils. As a significant contributor to P recycling, soil bacteria secrete extracellular enzymes to degrade organic P (Po) in soils into the readily bioavailable Pi.
Yeonsoo Park, Mina Solhtalab, Wiriya Thongsomboon, Ludmilla Aristilde   +3 more
wiley   +1 more source

IL1RN and PRRX1 as a Prognostic Biomarker Correlated with Immune Infiltrates in Colorectal Cancer: Evidence from Bioinformatic Analysis

International Journal of Genomics, Volume 2022, Issue 1, 2022., 2022
The extensive morbidity of colorectal cancer (CRC) and the inferior prognosis of terminal CRC urgently call for reliable prognostic biomarkers. For this, we identified 704 differentially expressed genes (DEGs) by intersecting three datasets, GSE41328, GSE37364, and GSE15960 from Gene Expression Omnibus database, to maximize the accuracy of the results.
Qi Wang, Xufeng Huang, Shujing Zhou, Yuntao Ding, Huizhi Wang, Weiye Jiang, Min Xu, Monika Dmitrzak-Weglarz   +7 more
wiley   +1 more source

Asymmetric Addition and Cycloaddition Reactions with Ylidene‐Five‐Membered Heterocycles

Advanced Synthesis &Catalysis, Volume 363, Issue 23, Page 5196-5234, December 7, 2021., 2021
Abstract Five‐membered heterocycles bearing an exocyclic double bond have been successfully used as substrates in asymmetric addition and cycloaddition reactions. Ylidene‐heterocycles are attractive substrates due to their high functionalization and the presence of an electrophilic conjugated exocyclic double bound that can participate in nucleophilic ...
Ricardo Torán, Rubén Miguélez, Amparo Sanz‐Marco, Carlos Vila, José R. Pedro, Gonzalo Blay   +5 more
wiley   +1 more source

Identifcation of small molecule enzyme inhibitors as broad-spectrum anthelmintics [PDF]

, 2019
Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers, autoimmune disorders and infectious diseases. This is also a cornerstone approach for discovery and development of anthelmintics against nematode and flatworm parasites.
Aroian, Raffi V., Brindley, Paul J., Bulman, Christina A., Elfawal, Mostafa A., Helander, Jon, Janetka, James W., Mitreva, Makedonka, Rosa, Bruce A., Sakanari, Judy, Tyagi, Rahul, Wildman, Scott A.   +10 more
core   +2 more sources

Proteomics insights into the Burkholderia cenocepacia phosphorus stress response

Environmental Microbiology, Volume 23, Issue 9, Page 5069-5086, September 2021., 2021
Summary The Burkholderia cepacia complex is a group of Burkholderia species that are opportunistic pathogens causing high mortality rates in patients with cystic fibrosis. An environmental stress often encountered by these soil‐dwelling and pathogenic bacteria is phosphorus limitation, an essential element for cellular processes.
Holly Shropshire, Rebekah A. Jones, María M. Aguilo‐Ferretjans, David J. Scanlan, Yin Chen   +4 more
wiley   +1 more source

Tripartite parasitic and symbiotic interactions as a possible mechanism of horizontal gene transfer

Ecology and Evolution, Volume 11, Issue 11, Page 7018-7028, June 2021., 2021
Halyomorpha halys acquired phospholipase C (PLC) genes from Xenorhabdus through the mechanism of horizontal gene transfer (HGT), likely mediated by a nematode during its parasitizing an insect host. This study revealed that an herbivore might enhance adaptation through gaining genes from an endosymbiont of its parasite in the tripartite parasitic and ...
Chaoyang Zhao, Shaoming Miao, Yanfang Yin, Yanjuan Zhu, Paul Nabity, Raman Bansal, Chenxi Liu   +6 more
wiley   +1 more source

Complementary Sources of Protein Functional Information: The Far Side of GO. [PDF]

, 2016
The GO captures many aspects of functional annotations, but there are other alternative complementary sources of protein function information. For example, enzyme functional annotations are described in a range of resources from the Enzyme Commission (E ...
Furnham, N
core   +1 more source

Metal Fluorides as Analogs for Studies on Phosphoryl Transfer Enzymes [PDF]

, 2017
The 1994 structure of a transition state analog with AlF4- and GDP complexed to G1, a small G protein, heralded a new field of research into structure and mechanism of enzymes that manipulate transfer of the phosphoryl (PO3-) group.
Admiraal, Anderson, Antony, Batsanov, Baur, Baxter, Baxter, Baxter, Baxter, Berente, Bigay, Blackburn, Blackburn, Bock, Boone, Bowler, Bruice, Brunk, Burgos, Cavalli, Cleland, Cliff, Coleman, Du, Field, Fisher, Fovet, Frey, Geerlings, Graham, Graham, Griffin, Grigorenko, Grigorenko, Hemsworth, Henry, Higashijima, Hilbert, Himo, Hoffman, Hur, Issartel, Jackson, Jin, Jin, Jin, Kamerlin, Khrenova, Klink, Klähn, Knowles, Kowalinski, Lahiri, Lassila, Leigh, Lienhard, Liu, Lowe, Madhusudan, Maegley, Marcos, Martin, Martin, Maruta, Mesmer, Mildvan, Oldfield, Park, Pauling, Plotnikov, Praefcke, Prasad, Pylypenko, Pérez-Gallegos, Pérez-Gallegos, Ribeiro, Rittinger, Scheffzek, Schlichting, Schlichting, Senn, Sheftic, Shinoda, Shurki, Siegbahn, Smith, Sondek, Sośnicki, Sternweis, Thorsell, Topol, Toyoshima, Valiev, Wang, Warshel, Webster, Wolfenden, Zhang   +97 more
core   +5 more sources

Rates of Spontaneous Cleavage of Glucose, Fructose, Sucrose, and Trehalose in Water, and the Catalytic Proficiencies of Invertase and Trehalas [PDF]

, 2008
Most of the early experimental work on enzyme kinetics was based on the properties of yeast invertase (-fructo-furanosidase, EC 3.2.1.26), whose robust activity1 (together with the availability of a continuous polarimetric assay) enabled Michaelis and ...
Wolfenden, Richard, Yuan, Yang
core   +3 more sources