Results 71 to 80 of about 38,432 (313)

Synthesis of Substituted 1,2,4-Triazole-3-Thione Nucleosides Using E. coli Purine Nucleoside Phosphorylase

Biomolecules
1,2,4-Triazole derivatives have a wide range of biological activities. The most well-known drug that contains 1,2,4-triazole as part of its structure is the nucleoside analogue ribavirin, an antiviral drug. Finding new nucleosides based on 1,2,4-triazole
Ilya V. Fateev, Sobirdjan A. Sasmakov, Jaloliddin M. Abdurakhmanov, Abdukhakim A. Ziyaev, Shukhrat Sh. Khasanov, Farkhod B. Eshboev, Oybek N. Ashirov, Valeriya D. Frolova, Barbara Z. Eletskaya, Olga S. Smirnova, Maria Ya. Berzina, Alexandra O. Arnautova, Yulia A. Abramchik, Maria A. Kostromina, Alexey L. Kayushin, Konstantin V. Antonov, Alexander S. Paramonov, Valeria L. Andronova, Georgiy A. Galegov, Roman S. Esipov, Shakhnoz S. Azimova, Anatoly I. Miroshnikov, Irina D. Konstantinova   +22 more
doaj   +1 more source

Impaired cardiac glycolysis and glycogen depletion are linked to poor myocardial outcomes in juvenile male swine with metabolic syndrome and ischemia

Physiological Reports, 2023
Obesity continues to rise in the juveniles and obese children are more likely to develop metabolic syndrome (MetS) and related cardiovascular disease. Unfortunately, effective prevention and long‐term treatment options remain limited.
Mark Broadwin, Dwight D. Harris, Sharif A. Sabe, Elif Sengun, Amber J. Sylvestre, Boian S. Alexandrov, Frank W. Sellke, Anny Usheva   +7 more
doaj   +1 more source

Dietary essential oils modulate post‐mortem oxidative damage in trout fillets exposed to slaughter stress during frozen storage

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Slaughter is a critical phase in aquaculture that can severely compromise both animal welfare and product quality. Stress responses triggered during this stage may accelerate post‐mortem biochemical degradation and promote oxidative damage in fish fillets. Essential oils, known for their antioxidant and anti‐inflammatory properties,
Lucía Méndez, Giulia Secci, Lorena Barros, Gabriel Dasilva, Giuliana Parisi, Isabel Medina   +5 more
wiley   +1 more source

Reactive Oxygen Species: A Key Constituent in Cancer Survival

Biomarker Insights, 2018
Background: Cancer is one of the major heterogeneous disease with high morbidity and mortality with poor prognosis. Elevated levels of reactive oxygen species (ROS), alteration in redox balance, and deregulated redox signaling are common hallmarks of ...
Seema Kumari, Anil Kumar Badana, Murali Mohan G, Shailender G, RamaRao Malla   +4 more
doaj   +1 more source

Measurement of the Proteinase Inhibitors of the Bovine Pancreas by Radioimmunoassay [PDF]

, 1976
Bovine pancreas contains two polypeptide trypsin inhibitors that are not homologous and differ in their inhibitory activity towards chymotrypsin, kallikrein, elastase, and other serine proteinases. The Kunitz inhibitor and the Kazal inhibitor are present
Fink, Edwin, Greene, Lewis J., Peeters, H.   +2 more
core   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Ethenoguanines undergo glycosylation by nucleoside 2'-deoxyribosyltransferases at non-natural sites. [PDF]

PLoS ONE, 2014
Deoxyribosyl transferases and functionally related purine nucleoside phosphorylases are used extensively for synthesis of non-natural deoxynucleosides as pharmaceuticals or standards for characterizing and quantitating DNA adducts.
Wenjie Ye, Debamita Paul, Lina Gao, Jolita Seckute, Ramiah Sangaiah, Karupiah Jayaraj, Zhenfa Zhang, P Alexandre Kaminski, Steven E Ealick, Avram Gold, Louise M Ball   +10 more
doaj   +1 more source

Acclimation responses of Arabidopsis thaliana to sustained phosphite treatments [PDF]

, 2013
Phosphite () induces a range of physiological and developmental responses in plants by disturbing the homeostasis of the macronutrient phosphate. Because of its close structural resemblance to phosphate, phosphite impairs the sensing, membrane transport,
Berkowitz, O., Fenske, R., Finnegan, P.M., Hardy, G.E.S.J., Jost, R., Kollehn, D.O., Lambers, H., O'Brien, P.A.   +7 more
core   +2 more sources

Role of Glycoside Phosphorylases in Mannose Foraging by Human Gut Bacteria*

Journal of Biological Chemistry, 2013
Background: The relations between the gut microbiota, food, and host play a crucial role in human health. Results: Prevalent bacterial glycoside phosphorylases are able to break down dietary carbohydrates and the N-glycans lining the intestinal ...
S. Ladevèze, Laurence Tarquis, D. Cecchini, J. Bercovici, I. André, C. Topham, S. Morel, É. Laville, P. Monsan, V. Lombard, B. Henrissat, G. Potocki-Veronese   +11 more
semanticscholar   +1 more source

Individualized T3‐4N+ Rectal Cancer Treatment Strategies: Exploring the Efficacy of Preoperative Synchronized Lateral Lymph Node Simultaneous Integrated Boost Radiation Therapy

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Anatomical Diagram: It shows a cross‐section of the pelvic area highlighting the rectum and lateral lymph nodes, which are the focal points of the treatment strategy discussed in the paper. Flowchart: It outlines the treatment process from preoperative synchronized radiation therapy to the subsequent surgical procedures, illustrating the sequence of ...
Xinjue Shi, Siyao Zhong, Xianbin Zheng, Xianxiu Nan, Xuan Liu, Qiteng Liu, Jing Yuan, Yuyan Gao   +7 more
wiley   +1 more source