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The human phosphorylated pathway: a multienzyme metabolic assembly for l-serine biosynthesis
FEBS Journal, 2023 De novo l-serine biosynthesis in the mammalian astrocytes proceeds via a linear, three-step pathway (the phosphorylated pathway) catalysed by 3-phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase (PSAT) and phosphoserine phosphatase ...
Silvia Sacchi +2 more
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Effect of aging on the oxidative phosphorylation pathway
Mechanisms of Ageing and Development, 1990The proposed study was undertaken to investigate the effect of aging on control of the oxidative phosphorylation pathway. Flux control coefficients for adenine nucleotide translocase and cytochrome c oxidase were determined using the procedure of Groen et al. [J. Biol. Chem., 257 (1982) 137-144].
J R, Darnold, M L, Vorbeck, A P, Martin
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Activation of the FA pathway mediated by phosphorylation and ubiquitination
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2017Fanconi anemia (FA) is a devastating hereditary condition that impacts genome integrity, leading to clinical features such as skeletal and visceral organ malformations, attrition of bone marrow stem cells, and carcinogenesis. At least 21 proteins, when absent or defective, have been implicated in this disorder, and they together constitute the FA ...
Masamichi, Ishiai +5 more
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The effects of time delays in a phosphorylation–dephosphorylation pathway
Biophysical Chemistry, 2007Complex signaling cascades involve many interlocked positive and negative feedback loops which have inherent delays. Modeling these complex cascades often requires a large number of variables and parameters. Delay differential equation models have been helpful in describing inherent time lags and also in reducing the number of governing equations ...
J, Srividhya +2 more
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Phosphorylation Networks in the Abscisic Acid Signaling Pathway
2014Abscisic acid (ABA) is one of the major phytohormones and regulates various processes in the plant life cycle, for example, seed development and abiotic/biotic stress responses. Recent studies have made significant progress in elucidating ABA signaling and established a simple ABA signaling model consisting of three core components: PYR/PYL/RCAR ...
Taishi, Umezawa +2 more
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SIGNAL TRANSDUCTION PATHWAYS INVOLVING PROTEIN PHOSPHORYLATION IN PROKARYOTES
Annual Review of Biochemistry, 1991Bacteria are capable of sensing a wide variety of environmental signals, including changes in chemical concentrations, the presence of a host organism, or variation in physical parameters such as temperature, osmolarity, viscosity, or light.
Bourret, Robert B. +2 more
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