Results 261 to 270 of about 1,554,099 (296)

Effect of Selenium Deficiency on Phosphorylation of the AMPK Pathway in Rats

Biological Trace Element Research, 2015
Selenium is an important trace element for human health. Previous studies have raised concern that dietary selenium intake may change energy metabolism. AMP-activated protein kinase (AMPK) is a sensor of energy status that controls cellular energy homeostasis.
Shulan, He, Xiong, Guo, Wuhong, Tan, Xiaohui, Su, Jiangping, Li, Wang, Pan, Hongyan, Qiu   +6 more
openaire   +2 more sources

Signaling pathways regulating murine cardiac CREB phosphorylation

Biochemical and Biophysical Research Communications, 2006
Using the mouse Langendorff heart perfusion model, the signaling pathways that regulate cardiac CREB-S133 phosphorylation have been defined. In mouse hearts stimulated with isoproterenol (ISO) (10(-8) M), endothelin-1 (ET-1) (10(-8) M), and phorbol 12-myristate 13-acetate (TPA) (10(-7) M), CREB-S133 phosphorylation was attained only by TPA-treatment ...
Bailing, Li, Marcia A, Kaetzel, John R, Dedman   +2 more
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eIF4E Phosphorylation Downstream of MAPK Pathway

2014
Tumor cells are dependent on high protein synthesis rates to fuel their neoplastic growth. eIF4E is a 5′ mRNA cap-binding protein that recruits mRNA to the ribosome and exhibits oncogenic properties. Mitogens, nutrients and growth factors stimulate the MAPK and PI3K pathways that converge on eIF4E.
Luc Furic, Emma Beardsley, Ivan Topisirovic   +2 more
openaire   +1 more source

Phosphorylation of three proteins in the signaling pathway of bacterial chemotaxis

Cell, 1988
Six cytoplasmic che gene products are required for signal transduction in bacterial chemotaxis, but the nature of their biochemical interactions is not known. We show that in vitro the CheA protein becomes autophosphorylated in the presence of ATP.
J F, Hess, K, Oosawa, N, Kaplan, M I, Simon   +3 more
openaire   +2 more sources

Direct phosphorylation of proliferative and survival pathway proteins by RET

Surgery, 2005
Gain-of-function mutations in the RET tyrosine kinase receptor cause the multiple endocrine neoplasia syndromes type 2a and 2b, and medullary thyroid cancer. We have previously shown that RET signals through focal adhesion kinase (FAK) in medullary thyroid cancer cells and that extracellular signal-regulated kinase (ERK) activity can be blocked by pp2,
Ganesh R, Panta, Lihua, Du, Fiemu E, Nwariaku, Lawrence T, Kim   +3 more
openaire   +2 more sources

Redox regulation of the signaling pathways leading to eNOS phosphorylation

Free Radical Biology and Medicine, 2005
Oxidative stress mediates positive and negative effects on physiological processes. Recent reports show that H(2)O(2) induces phosphorylation and activation of endothelial nitric oxide synthase (eNOS) through an Akt-phosphorylation-dependent pathway.
Toru, Tanaka, Hajime, Nakamura, Junji, Yodoi, Eda T, Bloom   +3 more
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Signaling pathways activated by protein tyrosine phosphorylation in lymphocytes

Current Opinion in Immunology, 1994
Antigen and cytokine receptors induce rapid tyrosine phosphorylation of receptor subunits, other membrane proteins, and signaling components. Each receptor induces phosphorylation of a number of proteins. Although there is often overlap between targets of different receptors, any given receptor only induces phosphorylation of a subset of possible ...
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ATP Synthesis Pathways: Oxidative Phosphorylation

2002
The heart derives over 90% of its energy production from the oxidation of carbon-based fuels. Unlike glycolysis, which takes place in the cytosol, oxidative metabolism occurs in the mitochondria. Adult cardiac mitochondria are ellipsoid-shaped organelles typically ∼1µm long × 0.5µm in diameter.
openaire   +1 more source

TNF inhibits NKCC2 phosphorylation by a calcineurin-dependent pathway

American Journal of Physiology-Renal Physiology
The beneficial immunosuppressive effects of CsA are tempered by renal side effects including reduction of GFR, proximal tubule damage, reduced urinary concentration, fibrosis and hypertension. As chronic administration of CN inhibitors frequently induce hypertension and renal nephropathy in humans, understanding the molecular mechanisms by which CN ...
Shoujin Hao, Anna Pia Lasaracina, Jarred Epps, Nicholas R. Ferreri   +3 more
openaire   +2 more sources

Proteomics approaches to understand protein phosphorylation in pathway modulation

Current Opinion in Plant Biology, 2010
Signaling pathways in all organisms consist of series of phosphorylation and dephosphorylation events that define directionality and allow different levels of feedback-regulation. Mass spectrometry-based proteomic analyses in recent years have led to a proteome-wide identification of thousands of phosphorylation sites in various plant species.
openaire   +3 more sources