Results 31 to 40 of about 1,571,698 (347)
Nature Communications, 2021 PKCε is known to exert a role in genome protection by directly phosphorylating and switching the specificity of Aurora B. Here the authors identify SERBP1 as a parallel mitotic PKCε substrate controlling translation and ensuring the integrity of ...
Silvia Martini +11 more
doaj +1 more source
The role of serine/threonine phosphatases in human development: Evidence from congenital disorders
Frontiers in Cell and Developmental Biology, 2022 Reversible protein phosphorylation is a fundamental regulation mechanism in eukaryotic cell and organismal physiology, and in human health and disease.
Pieter Vaneynde +5 more
doaj +1 more source
HIF1a-dependent mitophagy facilitates cardiomyoblast differentiation
Cell Stress, 2020 Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process.
Jin-Feng Zhao +4 more
doaj +1 more source
eLife, 2021 Parkinson’s disease (PD) is a major and progressive neurodegenerative disorder, yet the biological mechanisms involved in its aetiology are poorly understood.
Francois Singh +5 more
doaj +1 more source
Phosphorylation of ovine rhodopsin. Identification of the phosphorylated sites [PDF]
Biochemical Journal, 1984 Light-dependent phosphorylation of sheep opsin was obtained in purified discs to which was added a partially purified preparation of rhodopsin kinase. A maximum ratio of 1.8 mol of phosphate/mol of rhodopsin bleached was obtained. Perturbing the lipid bilayer did not alter the phosphorylation ratio. Dephosphorylation in both segments and discs was only
J B C Findlay, P Thompson
openaire +3 more sources
The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids
eLife, 2016 The mechanistic Target of Rapamycin complex 1 (mTORC1) senses intracellular amino acid levels through an intricate machinery, which includes the Rag GTPases, Ragulator and vacuolar ATPase (V-ATPase).
Gerta Hoxhaj +9 more
doaj +1 more source
Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase
eLife, 2022 The p97/Cdc48 ATPase and its ubiquitin receptors Ufd1-Npl4 are essential to unfold ubiquitylated proteins in many areas of eukaryotic cell biology.
Ryo Fujisawa +2 more
doaj +1 more source
Phospho.ELM:a database of experimentally verified phosphorylation sites in eukaryotic proteins [PDF]
, 2004 BACKGROUND: Post-translational phosphorylation is one of the most common protein modifications. Phosphoserine, threonine and tyrosine residues play critical roles in the regulation of many cellular processes.
Blom, Nikolaj +8 more
core +3 more sources
Revisiting Frank–Starling: regulatory light chain phosphorylation alters the rate of force redevelopment (ktr) in a length-dependent fashion [PDF]
, 2016 Force and power in cardiac muscle have a known dependence on phosphorylation of the myosin-associated regulatory light chain (RLC). We explore the effect of RLC phosphorylation on the ability of cardiac preparations to redevelop force (ktr ) in maximally
Abraham +72 more
core +1 more source
On the Control of TCR Phosphorylation [PDF]
Frontiers in Immunology, 2012 The T-cell receptor (TCR) is responsible first of all for recognizing small peptides embedded in major histocompatibility complex molecules (pMHC). The information that a complex has thus formed is then transduced across the membrane via “triggering” of the TCR.
Fernandes, R +4 more
openaire +4 more sources