Results 21 to 30 of about 953,482 (170)
Nature Communications, 2021 PKCε is known to exert a role in genome protection by directly phosphorylating and switching the specificity of Aurora B. Here the authors identify SERBP1 as a parallel mitotic PKCε substrate controlling translation and ensuring the integrity of ...
Silvia Martini +11 more
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PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
eLife, 2019 Mutations that activate LRRK2 protein kinase cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases within their Switch-II motif controlling interaction with effectors.
Kerryn Berndsen +11 more
doaj +1 more source
Journal of Advanced Research, 2023 Introduction: The structural and dynamic determinants that confer highly selective RET kinase inhibition are poorly understood. Objectives: To explore the druggability landscape of the RET active site in order to uncover structural and dynamic ...
Moustafa A. Shehata +6 more
doaj +1 more source
To phosphorylate or not to phosphorylate [PDF]
Cell Adhesion & Migration, 2013 EphB tyrosine kinase receptors have been implicated in multiple developmental processes; however, the signaling mechanism underlying these events remains unclear. Through a triple knock-in mouse line for three neurally expressed EphBs, Sokis et al. demonstrated that EphB tyrosine kinase activity is required for axon guidance but does not influence ...
Dhanasak, Dhanasobhon +2 more
openaire +2 more sources
USP45 and Spindly are part of the same complex implicated in cell migration
Scientific Reports, 2018 Ubiquitylation is a protein modification implicated in several cellular processes. This process is reversible by the action of deubiquinating enzymes (DUBs).
Claudia Conte +3 more
doaj +1 more source
Determination of VPS34/PIK3C3 Activity in vitro Utilising 32P-γATP
Bio-Protocol, 2016 VPS34 is the only class III phosphatidylinositol-3-kinase (PI3K) in mammalian cells and produces the vast majority of cellular phosphatidylinositol-3-phosphate [PI(3)P].
Michael Munson, Ian Ganley
doaj +1 more source
Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes
eLife, 2021 Tissue-resident intestinal intraepithelial T lymphocytes (T-IEL) patrol the gut and have important roles in regulating intestinal homeostasis. T-IEL include both induced T-IEL, derived from systemic antigen-experienced lymphocytes, and natural T-IEL ...
Alejandro J Brenes +8 more
doaj +1 more source
Phosphorylation of ovine rhodopsin. Identification of the phosphorylated sites [PDF]
Biochemical Journal, 1984 Light-dependent phosphorylation of sheep opsin was obtained in purified discs to which was added a partially purified preparation of rhodopsin kinase. A maximum ratio of 1.8 mol of phosphate/mol of rhodopsin bleached was obtained. Perturbing the lipid bilayer did not alter the phosphorylation ratio. Dephosphorylation in both segments and discs was only
P, Thompson, J B, Findlay
openaire +2 more sources
Characteristics of phosphorylated and non-phosphorylated dentine phosphoprotein [PDF]
Biochemical Journal, 1992 Heterogeneity among the odontoblast-specific, highly phosphorylated acidic protein dentine phosphoprotein (DPP) obtained from different species has been reported by several investigators. In the present study, the apparent molecular-mass variations in rabbit and mouse DPP were investigated.
M, MacDougall +2 more
openaire +2 more sources
Nature Communications, 2023 Autophosphorylation controls the transition between discrete functional and conformational states in protein kinases, yet the structural and molecular determinants underlying this fundamental process remain unclear.
Hipólito Nicolás Cuesta-Hernández +10 more
doaj +1 more source