Results 21 to 30 of about 1,594,903 (314)

Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae [PDF]

, 2014
The chromosomal passenger complex (CPC) is a key regulator of eukaryotic cell division, consisting of the protein kinase Aurora B/Ipl1 in association with its activator (INCENP/Sli15) and two additional proteins (Survivin/Bir1 and Borealin/Nbl1). Here we
Corbishley, Stephen, Makrantoni, Vasso, Morrice, Nicholas A., Rachidi, Najma, Robinson, David A., Stark, Michael J. R.   +5 more
core   +10 more sources

Pathogenic FAM83G palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling. [version 1; peer review: 2 approved]

Wellcome Open Research, 2019
Background: Two recessive mutations in the FAM83G gene, causing A34E and R52P amino acid substitutions in the DUF1669 domain of the PAWS1 protein, are associated with palmoplantar keratoderma (PPK) in humans and dogs respectively.
Kevin Z.L. Wu, Rebecca A. Jones, Theresa Tachie-Menson, Thomas J. Macartney, Nicola T. Wood, Joby Varghese, Robert Gourlay, Renata F. Soares, James C. Smith, Gopal P. Sapkota   +9 more
doaj   +1 more source

Revisiting Frank–Starling: regulatory light chain phosphorylation alters the rate of force redevelopment (ktr) in a length-dependent fashion [PDF]

, 2016
Force and power in cardiac muscle have a known dependence on phosphorylation of the myosin-associated regulatory light chain (RLC). We explore the effect of RLC phosphorylation on the ability of cardiac preparations to redevelop force (ktr ) in maximally
Abraham, Adhikari, Aoki, Araujo, Barany, Blue, Bremel, Brenner, Brenner, Colson, Curtin, Davis, Ding, Ferenczi, Fitzsimons, Greenberg, Greenberg, Gu, Guccione, Hanft, Hanft, He, Hidalgo, Hooijman, Huang, Huxley, Huxley, Ishijima, Karabina, Katz, Kentish, Korte, Levine, Mansfield, Metzger, Milani-Nejad, Morano, Morano, Moss, Muthu, Nag, Nishio, Nyitrai, Okamoto, Olsson, Pate, Patel, Podolsky, Prakash, Prakash, Pulcastro, Regnier, Regnier, Regnier, Rhodes, Sanbe, Scruggs, Sheikh, Sheikh, Sonnenblick, Stelzer, Stelzer, Stracher, Sweeney, Takagi, Toepfer, Tombe, Tombe, Ueno, Wang, Warren, Wolff, Yuan   +72 more
core   +1 more source

Mapping the phosphoproteome of influenza A and B viruses by mass spectrometry [PDF]

, 2012
Protein phosphorylation is a common post-translational modification in eukaryotic cells and has a wide range of functional effects. Here, we used mass spectrometry to search for phosphorylated residues in all the proteins of influenza A and B viruses ...
Denham, Eleanor M., Fodor, Ervin, Hester, Svenja S., Hutchinson, Edward C., Ridlova, Gabriela, Thomas, Benjamin, Trudgian, David C., Turrell, Lauren, York, Ashley   +8 more
core   +3 more sources

Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4TopBP1 [PDF]

, 2013
The BRCT-domain protein Rad4(TopBP1) facilitates activation of the DNA damage checkpoint in Schizosaccharomyces pombe by physically coupling the Rad9-Rad1-Hus1 clamp, the Rad3(ATR) -Rad26(ATRIP) kinase complex, and the Crb2(53BP1) mediator.
Alcasabas, Antony M. Carr, Antony W. Oliver, Boos, Cescutti, Christopher P. Wardlaw, Du, Du, Du, Esashi, Fenech, Fukuura, Furuya, Garcia, Gong, Jing-Yi Ren, Kilkenny, Kumagai, Kumagai, Kumagai, Laurence H. Pearl, Lee, Lee, Li-Lin Du, Lin, Mathieu Rappas, Matthew Day, Meng Qu, Qu, Rappas, Rothbauer, Saka, Shiozaki, Smits, Stucki, Takeishi, Tanaka, Taylor, Valerie Garcia, Williams, Willson   +40 more
core   +1 more source

Prevention and partial reversion of the lupus phenotype in ABIN1[D485N] mice by an IRAK4 inhibitor

Lupus Science and Medicine, 2021
Objective We have reported previously that the IRAK4 inhibitor PF06426779 given to ubiquitin-binding-defective ABIN1[D485N] mice at 6 weeks of age prevents the major facets of lupus that develop 10 weeks later.
Philip Cohen, Tsvetana Petrova, Sambit K Nanda, Cheryl Scudamore, Stephen W Wright, Vikram R Rao   +5 more
doaj   +1 more source

Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase

eLife, 2022
The p97/Cdc48 ATPase and its ubiquitin receptors Ufd1-Npl4 are essential to unfold ubiquitylated proteins in many areas of eukaryotic cell biology.
Ryo Fujisawa, Cristian Polo Rivera, Karim PM Labib   +2 more
doaj   +1 more source

Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway [PDF]

, 2003
Objective. Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation of erythroid cells.
Bieber, Boer, Chung, Decker, Gabrilove, Gonzalez, Goodnough, Gotoh, Haq, Jain, Jain, Jonk, Kaptein, Kirito, Kirito, Kirito, Lim, Millot, Miyazaki, Mulcahy, Ng, Schuringa, Schuringa, Schuringa, Smithgall, Socolovsky, Teglund, Tilbrook, Turkson, Watowich, Wen, Wen, Woetmann, Yokogami, Youssoufian, Yu, Zhang   +36 more
core   +1 more source

Mapping and Functional Role of Phosphorylation Sites in the Thyroid Transcription Factor-1 (TTF-1) [PDF]

, 1996
The phosphorylation of thyroid transcription factor-1 (TTF-1), a homeodomain-containing transcription factor that is required for thyroid-specific expression of the thyroglobulin and thyroperoxidase gene promoters, has been studied.
Acebron, Alvaro, Arnone, Maria Ina, De Felice, Mario, Di Lauro, Roberto, Martin-Pérez, Jorge, Santisteban, Pilar, Zannini, Mariastella   +6 more
core   +1 more source

An Affinity-directed Protein Missile (AdPROM) System for Targeted Destruction of Endogenous Proteins

Bio-Protocol, 2017
We recently reported an Affinity-directed PROtein Missile (AdPROM) system for the targeted proteolysis of endogenous proteins of interest (POI) (Fulcher et al., 2016 and 2017).
Thomas Macartney, Gopal Sapkota, Luke Fulcher   +2 more
doaj   +1 more source