Results 31 to 40 of about 1,252,336 (318)

Phosphorylation of acetylhexosamines [PDF]

Archives of Biochemistry and Biophysics, 1958
Abstract The phosphorylation of acetylglucosamine and acetylgalactosamine by adenosine triphosphate catalyzed by extracts of rat organs has been studied. The reaction products had the properties of acetylglucosamine 6-phosphate and acetylgalactosamine 1-phosphate, respectively. The enzymes appear to be different from other kinases.
Leloir, Luis Federico, Cardini, Carlos E., Olavarría, José M.   +2 more
openaire   +3 more sources

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

eLife, 2016
The mechanistic Target of Rapamycin complex 1 (mTORC1) senses intracellular amino acid levels through an intricate machinery, which includes the Rag GTPases, Ragulator and vacuolar ATPase (V-ATPase).
Gerta Hoxhaj, Edward Caddye, Ayaz Najafov, Vanessa P Houde, Catherine Johnson, Kumara Dissanayake, Rachel Toth, David G Campbell, Alan R Prescott, Carol MacKintosh   +9 more
doaj   +1 more source

Pharmacological rescue of impaired mitophagy in Parkinson’s disease-related LRRK2 G2019S knock-in mice

eLife, 2021
Parkinson’s disease (PD) is a major and progressive neurodegenerative disorder, yet the biological mechanisms involved in its aetiology are poorly understood.
Francois Singh, Alan R Prescott, Philippa Rosewell, Graeme Ball, Alastair D Reith, Ian G Ganley   +5 more
doaj   +1 more source

Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae [PDF]

, 2014
The chromosomal passenger complex (CPC) is a key regulator of eukaryotic cell division, consisting of the protein kinase Aurora B/Ipl1 in association with its activator (INCENP/Sli15) and two additional proteins (Survivin/Bir1 and Borealin/Nbl1). Here we
David A Robinson, Robinson, David A., Corbishley, Stephen, Stark, Michael J. R., Vasso Makrantoni, Michael J R Stark, Makrantoni Vasso, Najma Rachidi, Morrice Nicholas A., Robinson David A., Corbishley Stephen J., Makrantoni, Vasso, Stephen J Corbishley, Stark Michael J. R., Nicholas A Morrice, Rachidi, Najma, Morrice, Nicholas A., Rachidi Najma   +17 more
core   +1 more source

HIF1a-dependent mitophagy facilitates cardiomyoblast differentiation

Cell Stress, 2020
Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process.
Jin-Feng Zhao, Catherine E. Rodger, George F. G. Allen, Simone Weidlich, Ian G. Ganley   +4 more
doaj   +1 more source

The role of serine/threonine phosphatases in human development: Evidence from congenital disorders

Frontiers in Cell and Developmental Biology, 2022
Reversible protein phosphorylation is a fundamental regulation mechanism in eukaryotic cell and organismal physiology, and in human health and disease.
Pieter Vaneynde, Pieter Vaneynde, Iris Verbinnen, Iris Verbinnen, Veerle Janssens, Veerle Janssens   +5 more
doaj   +1 more source

Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation [PDF]

, 2009
Splicing requires reversible phosphorylation of serine/arginine-rich (SR) proteins, which direct splice site selection in eukaryotic mRNA. These phosphorylation events are dependent on SR protein (SRPK) and cdc2-like kinase (CLK) families.
Bullock, AN, Niesen, Frank H., Amos, AL, Ghosh, Gourisankar, Turk, BE, Fedorov, Oleg, Cho, S, Amos, Ann L, Papagrigoriou, E, Niesen, FH, Cho, Suhyung, Guo, K, Bullock, Alex N., Knapp, Stefan, Papagrigoriou, Evangelos, Turk, Benjamin E, Knapp, S, Amos, Ann L., Fedorov, O, Debreczeni, Judit É., Das, Sanjan, Ghosh, G, Rellos, P, Debreczeni, Judit E, Rellos, Peter, Guo, Kunde, Das, S, Bullock, Alex N, Niesen, Frank H, Bullock, Alexander, Debreczeni, JE, Turk, Benjamin E.   +31 more
core   +1 more source

PKCɛ switches Aurora B specificity to exit the abscission checkpoint

Nature Communications, 2016
The Aurora B abscission checkpoint is activated when DNA is retained in the cleavage furrow on completion of anaphase. Here the authors show that PKCɛ directly phosphorylates Aurora B triggering a switch in Aurora B substrate specificity to elicit ...
Tanya Pike, Nicola Brownlow, Svend Kjaer, Jeremy Carlton, Peter J. Parker   +4 more
doaj   +1 more source

A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division

Nature Communications, 2021
PKCε is known to exert a role in genome protection by directly phosphorylating and switching the specificity of Aurora B. Here the authors identify SERBP1 as a parallel mitotic PKCε substrate controlling translation and ensuring the integrity of ...
Silvia Martini, Khalil Davis, Rupert Faraway, Lisa Elze, Nicola Lockwood, Andrew Jones, Xiao Xie, Neil Q. McDonald, David J. Mann, Alan Armstrong, Jernej Ule, Peter J. Parker   +11 more
doaj   +1 more source

Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylation [PDF]

, 2015
During mitosis, Bub1 kinase phosphorylates histone H2A-T120 to promote centromere sister chromatid cohesion through recruitment of shugoshin (Sgo) proteins. The regulation and dynamics of H2A-T120 phosphorylation are poorly understood. Using quantitative
Lajeunesse, Audrey, Asghar, Adeel, Combes, Guillaume, Thebault, Philippe, Dulla, Kalyan, Elowe, Sabine, Nigg, Erich A.   +6 more
core   +1 more source