Results 91 to 100 of about 5,158 (158)

miR-424 targets AKT3 and PSAT1 and has a tumor-suppressive role in human colorectal cancer

Cancer Management and Research, 2018
Yifeng Fang,1 Xiao Liang,1 Junfen Xu,2 Xiujun Cai1 1Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; 2Department of Gynecologic Oncology, Women’s Hospital, Zhejiang University School
Fang Y, Liang X, Xu J, Cai X
doaj  

Quantitative proteomics of a B12 -dependent alga grown in coculture with bacteria reveals metabolic tradeoffs required for mutualism [PDF]

, 2017
The unicellular green alga Lobomonas rostrata requires an external supply of vitamin B12 (cobalamin) for growth, which it can obtain in stable laboratory cultures from the soil bacterium Mesorhizobium loti in exchange for photosynthate.
Amin, Amin, Arrigo, Ashen, Beliaev, Bertrand, Bertrand, Biller, Bradford, Catalano, Chauvin, Cooper, Copley, Croft, Durham, Eisenreich, Elias, Emerich, Falkowski, Fernandes, Geng, González, Grant, Helliwell, Helliwell, Helliwell, Hold, Hom, Kanehisa, Kazamia, Kazamia, Koch, Koch, Liu, Lodwig, Lohse, Longworth, Matsuo, Maxwell, Mus, Nedelcu, Noirel, Ohlrogge, Paerl, Palmer, Pandhal, Panter, Park, Pfaffl, Saalbach, Saibil, Schmollinger, Shargool, Sher, Song, Tai, Thiel, Untergasser, Vizcaíno, Wagner-Döbler, Wienkoop, Xie, Zhang   +62 more
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Serine starvation suppresses the progression of esophageal cancer by regulating the synthesis of purine nucleotides and NADPH

Cancer & Metabolism
Serine metabolism provides important metabolic intermediates that support the rapid proliferation of tumor cells. However, the role of serine metabolism in esophageal squamous cell carcinoma (ESCC) and the underlying mechanism remains unclear.
Hui Jie, Jing Wei, Zhuoling Li, Min Yi, Xinying Qian, Yan Li, Chunqi Liu, Chuan Li, Liang Wang, Pengchi Deng, Lunxu Liu, Xiaobo Cen, Yinglan Zhao   +12 more
doaj   +1 more source

Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer [PDF]

, 2010
Cancer cells adapt their metabolic processes to drive macromolecular biosynthesis for rapid cell growth and proliferation[superscript 1, 2]. RNA interference (RNAi)-based loss-of-function screening has proven powerful for the identification of new and ...
A Bric, A Marson, Abhishek K. Jha, Albert M. Chan, B Luo, Bingbing Yuan, D Wiederschain, DA Walsh, David E. Root, David M. Sabatini, Dohoon Kim, DR Rhodes, Edward M. Driggers, Elena F. Brachtel, FR Miller, FR Miller, Francesca G. Barrett, Glenn S. Cowley, Hin-Koon Woo, Hyun G. Jang, I Ben-Porath, J Debnath, J Kim, J Moffat, JM Buescher, Jordi Barretina, K Lund, K Snell, Kathleen Ottina, Kevin M. Marks, Kıvanç Birsoy, Levi A. Garraway, Mari Mino-Kenudson, Michael E. Pacold, MJ van de Vijver, Nada Y. Kalaany, Nicolas Stransky, NY Kalaany, Peggy P. Hsu, PP Hsu, R Beroukhim, RG Jones, Richard Possemato, RJ DeBerardinis, S Pollari, Shalini Sethumadhavan, TS Mikkelsen, Walter W. Chen, WE Knox, Y Achouri, Y Sancak, Yoav D. Shaul, Zhi-Yang Tsun   +52 more
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Comparisons of Transcriptional Profiles of Gut Genes between Cry1Ab-Resistant and Susceptible Strains of Ostrinia nubilalis Revealed Genes Possibly Related to the Adaptation of Resistant Larvae to Transgenic Cry1Ab Corn [PDF]

, 2017
Citation: Yao, J. X., Zhu, Y. C., Lu, N. Y., Buschman, L. L., & Zhu, K. Y. (2017). Comparisons of Transcriptional Profiles of Gut Genes between Cry1Ab-Resistant and Susceptible Strains of Ostrinia nubilalis Revealed Genes Possibly Related to the ...
Buschman, Lawrent L., Lu, N. Y., Yao, Jianxiu, Zhu, Kun Y., Zhu, Y. C.   +4 more
core   +2 more sources

Probing the role of Coniferin and Tetrahydrocurcumin from Traditional Chinese medicine against PSAT1 in early-stage ovarian cancer: An in silico study.

PLoS ONE
Ovarian cancer, a formidable gynaecological malignancy, poses a significant global health challenge, and it is characterised by late-stage diagnosis and a high mortality rate. Even in its early stages, when treatment choices are scarce, ovarian cancer is
Jia Zhang, Shalesh Gangwar, Nagmi Bano, Shaban Ahmad, Mohammed S Alqahtani, Khalid Raza   +5 more
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Phosphorylation of CREB affects its binding to high and low affinity sites [PDF]

, 1992
Cyclic AMP treatment of hepatoma cells leads to increased protein binding at the cyclic AMP response element (CRE) of the tyrosine aminotransferase (TAT) gene in vivo, as revealed by genomic footprinting, whereas no increase is observed at the CRE of the
Boshart, Michael, DeVack, Carol, Kowenz-Leutz, Elisabeth, Luckow, Bruno, Nichols, Mark, Schmid, Wolfgang, Schütz, Günther, Weih, Falk   +7 more
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Ambiguity of human gene symbols in LocusLink and MEDLINE: creating an inventory and a disambiguation test collection [PDF]

, 2003
Genes are discovered almost on a daily basis and new names have to be found. Although there are guidelines for gene nomenclature, the naming process is highly creative.
Eijk, C.C. (Christiaan) van der, Jelier, R. (Rob), Kors, J.A. (Jan), Mons, B. (Barend), Mulligen, E.M. (Erik) van, Schijvenaars, R.J.A. (Bob), Weeber, M. (Marc)   +6 more
core  

Histone lactylation-boosted AURKB facilitates colorectal cancer progression by inhibiting HNRNPM-mediated PSAT1 mRNA degradation

Journal of Experimental & Clinical Cancer Research
Background Aurora kinase B (AURKB), a key regulator of mitosis, is frequently upregulated in various malignancies, including colorectal cancer (CRC), and is associated with poor prognosis.
Yuyi Li, Jinjin Peng, Di Wu, Qingxin Xie, Yichao Hou, Linjing Li, Xintian Zhang, Yu Liang, Jing Feng, Jiaqing Chen, Wangshuang Chen, Che Xu, Han Yao, Xiangjun Meng   +13 more
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Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama, Bruce C. Richardson, Dipak Patel, Faith M. Strickland, Sushma Yarlagadda   +4 more
core   +1 more source