Results 11 to 20 of about 5,158 (158)

MicroRNA-340 Inhibits Esophageal Cancer Cell Growth and Invasion by Targeting Phosphoserine Aminotransferase 1 [PDF]

Cellular Physiology and Biochemistry, 2015
Background/Aims: Emerging evidence indicates that microRNA (miR)-340 is downregulated in various human cancers, suggesting that it acts as a tumor suppressor.
Shuo Yan, Haosheng Jiang, Shiming Fang, Fang Yin, Zhenlei Wang, Yiping Jia, Xianjun Sun, Shaoqiu Wu, Tinghui Jiang, Aiwu Mao   +9 more
doaj   +3 more sources

Overexpression of Phosphoserine Aminotransferase 1 (PSAT1) Predicts Poor Prognosis and Associates with Tumor Progression in Human Esophageal Squamous Cell Carcinoma [PDF]

Cellular Physiology and Biochemistry, 2016
Background/Aims: Phosphoserine aminotransferase 1 (PSAT1) is over-expressed in many carcinoma tissues, however little is known regarding its expression and function in esophageal carcinogenesis.
Bingyan Liu, Yiping Jia, Yan Cao, Shaoqiu Wu, Haosheng Jiang, Xianjun Sun, Jun Ma, Xiang Yin, Aiwu Mao, Mingyi Shang   +9 more
doaj   +3 more sources

Structural Analysis of Phosphoserine Aminotransferase (Isoform 1) From Arabidopsis thaliana– the Enzyme Involved in the Phosphorylated Pathway of Serine Biosynthesis [PDF]

Frontiers in Plant Science, 2018
Phosphoserine aminotransferase (PSAT) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes the conversion of 3-phosphohydroxypyruvate (3-PHP) to 3-phosphoserine (PSer) in an L-glutamate (Glu)-linked reversible transamination reaction.
Bartosz Sekula, Milosz Ruszkowski, Zbigniew Dauter   +2 more
doaj   +3 more sources

Hydrocortisone interacts with endoplasmic reticulum stress in hypoxic regulation of phosphoserine aminotransferase 1 gene expression differently in normal human astrocytes and glioblastoma cells

Endocrine Regulations
Objective. Endoplasmic reticulum (ER) stress and hypoxia are key factors for the effective growth of malignant tumors, including glioblastoma. The phosphoserine aminotransferase 1 (PSAT1) is an ER stress-responsive enzyme responsible for serine synthesis
Minchenko Oleksandr H., Abramchuk Anastasiia I., Khikhlo Yevgen P., Sliusar Myroslava Y., Halkin Oleh V., Luzina Olha Y., Danilovsryi Serhiy V., Viletska Yuliia M., Minchenko Dmytro O.   +8 more
doaj   +3 more sources

Examination of the effects of microRNA-145-5p and phosphoserine aminotransferase 1 in colon cancer. [PDF]

Bioengineered, 2022
Previous studies manifested that microRNA-145-5p is pivotal in the development of various cancers. Nevertheless, the potential function of microRNA-145-5p in colorectal cancer remains unclear. This study attempted to investigate the potential role and possible mechanism of microRNA-145-5p in colon cancer.
Ding R, Hong W, Huang L, Shao J, Yu W, Xu X.   +5 more
europepmc   +3 more sources

The protective effects of phosphoserine aminotransferase 1 (PSAT1) against hepatic ischemia-reperfusion injury. [PDF]

J Cell Commun Signal, 2023
Hepatic ischemia-reperfusion (I/R) injury is a severe clinical syndrome, causing a profound medical and socioeconomic burden worldwide. This study aimed to explore underlying biomarkers and treatment targets in the progression of hepatic I/R injury. We screened gene expression profiles of the hepatic I/R injury from the Gene Expression Omnibus (GEO ...
Deng Y, Luo H.
europepmc   +3 more sources

Nuclear Pyruvate Kinase M2 (PKM2) Contributes to Phosphoserine Aminotransferase 1 (PSAT1)-Mediated Cell Migration in EGFR-Activated Lung Cancer Cells. [PDF]

Cancers (Basel), 2021
An elevated expression of phosphoserine aminotransferase 1 (PSAT1) has been observed in multiple tumor types and is associated with poorer clinical outcomes. Although PSAT1 is postulated to promote tumor growth through its enzymatic function within the serine synthesis pathway (SSP), its role in cancer progression has not been fully characterized. Here,
Biyik-Sit R, Kruer T, Dougherty S, Bradley JA, Wilkey DW, Merchant ML, Trent JO, Clem BF.   +7 more
europepmc   +4 more sources

Phosphoserine aminotransferase 1 promotes serine synthesis pathway and cardiac repair after myocardial infarction. [PDF]

Theranostics
Magadum A, Mallaredy V, Roy R, Joladarashi D, Thej C, Cheng Z, Cimini M, Truongcao M, Chatoff A, Crispim CV, Rigaud VOC, Gonzalez C, Benedict C, Santos CXC, Snyder NW, Khan M, Shah AM, Koch WJ, Kishore R.   +18 more
europepmc   +3 more sources

Cancer-associated Fibroblast-like Cells Promote Osteosarcoma Metastasis by Upregulation of Phosphoserine Aminotransferase 1 and Activation of the mTOR/S6K Pathway. [PDF]

Int J Biol Sci
Metastasis remains a major obstacle limiting the survival of patients with osteosarcoma (OS). Cross-talk between cancer-associated fibroblasts (CAFs) and OS cells has been found to facilitate metastasis, although the effects of CAFs on OS cell metabolism are poorly understood.
Feng L, Xiao G, Chen Y, Ye T, Fan L, Xie Y, Mei T, Wang L, Ge J, Ye C, Chen J.   +10 more
europepmc   +2 more sources

A phosphoserine phosphatase variant present in the brain of Alzheimer's disease patients favors nuclear mistargeting. [PDF]

FEBS J
l‐serine levels in the human brain are maintained by the phosphorylated pathway, a three‐step process catalyzed by phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase (PSAT) and phosphoserine phosphatase (PSP). These enzymes assemble in a metabolon called the serinosome. The double R27S/D32G PSP variant was identified in the brain of
Sacchi S, Buoli Comani V, Arisi I, Marchesani F, Rabattoni V, De Bei O, Motta Z, Peracchi A, Bruno S, Pollegioni L, Campanini B.   +10 more
europepmc   +2 more sources