Results 51 to 60 of about 5,158 (158)

Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells

Biochemistry and Biophysics Reports, 2019
Skeletal muscle is a highly metabolic and dynamic tissue that is formed through the complex and well-organised process of myogenesis. Although there is a good understanding about the role of the Muscle Regulatory Factors during myogenesis, little is ...
Madelaine C. Brearley, Congcong Li, Zoe C.T.R. Daniel, Paul T. Loughna, Tim Parr, John M. Brameld   +5 more
doaj   +1 more source

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis [PDF]

, 2010
Most tumors exhibit increased glucose metabolism to lactate, however, the extent to which glucose-derived metabolic fluxes are used for alternative processes is poorly understood [1, 2].
Adam J Bass, AL Richardson, Alexandra R Grassian, Andrea L Richardson, Atsuo T Sasaki, Azra H Ligon, CA Fernandez, CB Thompson, CH Eng, Christian M Metallo, Costas A Lyssiotis, Dimitrios Anastasiou, DJ Slamon, DK Nomura, DR Rhodes, Edouard Mullarky, G Bodenhausen, Gerhard Wagner, Gregory Heffron, Gregory Stephanopoulos, H Bismut, Hadar Sharfi, J Debnath, J Greshock, J Luo, Jason W Locasale, Joan S Brugge, John M Asara, JW Locasale, K Hara, K Hoek, K Snell, Katherine R Mattaini, L Tabatabaie, Lewis C Cantley, Lynda Chin, Matthew G Vander Heiden, Matthew Meyerson, MG Vander Heiden, MG Vander Heiden, Mika Sasaki, MR Antoniewicz, Natalie I Vokes, O Warburg, R Beroukhim, R Teperino, Rameen Beroukhim, RJ DeBerardinis, S Kit, S Pollari, Tamar Melman, Taru Muranen, TJ de Koning, W Lu, WD Foulkes, Y Achouri, ZT Schafer   +56 more
core   +1 more source

Valproate induces the unfolded protein response by increasing ceramide levels [PDF]

, 2016
Bipolar disorder (BD), which is characterized by depression and mania, affects 1–2% of the world population. Current treatments are effective in only 40–60% of cases and cause severe side effects.
Cottier, Stéphanie, Cowart, Ashley, Greenberg, Miriam L., Jadhav, Shyamalagauri, Russo, Sarah, Schneiter, Roger   +5 more
core   +1 more source

Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome

Food Biomacromolecules, EarlyView.
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley   +1 more source

Choice of Bacterial Growth Medium Alters the Transcriptome and Phenotype of Salmonella enterica Serovar Typhimurium [PDF]

, 2013
The type of bacterial culture medium is an important consideration during design of any experimental protocol. The aim of this study was to understand the impact of medium choice on bacterial gene expression and physiology by comparing the transcriptome ...
A Buckley, A Haraga, A Sturm, AK Lee, Al Ivens, AM Bailey, Andrew J. Roe, Andrew M. Bailey, BK Coombes, C Wray, CR Beuzón, D Cirillo, D Zhou, DM Cirillo, FC Neidhardt, Grace E. Richmond, H Ochman, H Tao, I Hautefort, I Hautefort, J Deiwick, J Garmendia, Jessica M. A. Blair, JMA Blair, KA Christensen, L Clark, Laura J. V. Piddock, M Hensel, MA Webber, MA Webber, MP Dibb-Fuller, O Steele-Mortimer, S Eriksson, SA Bustin, SE Majowicz, V Bajaj   +35 more
core   +3 more sources

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

Overexpression of microRNA-195-5p reduces cisplatin resistance and angiogenesis in ovarian cancer by inhibiting the PSAT1-dependent GSK3β/β-catenin signaling pathway

Journal of Translational Medicine, 2019
Background Ovarian cancer (OC) is one of the leading causes for cancer-related deaths among women. MicroRNAs (miRs) have been proved to be vital to the development and progression of OC.
Jun Dai, Rujia Wei, Peihai Zhang, Beihua Kong   +3 more
doaj   +1 more source

Moderate strength (0.23–0.28 T) static magnetic fields (SMF) modulate signaling and differentiation in human embryonic cells [PDF]

, 2009
Background Compelling evidence exists that magnetic fields modulate living systems. To date, however, rigorous studies have focused on identifying the molecular-level biosensor (e.g., radical ion pairs or membranes) or on the behavior of whole animals ...
Zhiyun Wang, Anshu Sarje, Pao-Lin Che, Kevin J Yarema   +3 more
core   +1 more source

Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins [PDF]

, 2008
We report an advanced chemoenzymatic strategy for the direct fluorescence detection, proteomic analysis, and cellular imaging of O-GlcNAc-modified proteins.
Agnew, Brian J., Buck, Suzanne B., Clark, Peter M., Dweck, Jessica F., Hart, Courtenay R., Hsieh-Wilson, Linda C., Mason, Daniel E., Peters, Eric C.   +7 more
core   +1 more source

Bioinformatics‐based discovery of the involvement of PSAT1 in mediating the anti‐lung adenocarcinoma activity of triptolide

Animal Models and Experimental Medicine, Volume 9, Issue 1, Page 115-127, January 2026.
Transcriptome sequencing was performed on tumor tissues from triptolide‐treated tumor‐bearing mice. The sequencing results were integrated with data from public databases for comprehensive analysis, and potential regulatory targets of triptolide were identified.
Zhiwen Cao, Lulu Zhang, Wenqiang Zhang, Rong Wan, Xiaogang Peng, Jinyan Xie, Ruru Bai, Jiejing Jin, Changqi Shi, Lan Yan, Xiangyu Guo, Yang Shen, Cheng Lu   +12 more
wiley   +1 more source