Results 81 to 90 of about 5,158 (158)

Metabolic Reprogramming: A Crucial Contributor to Anticancer Drug Resistance

MedComm, Volume 6, Issue 9, September 2025.
Role of metabolic reprogramming in drug resistance in cancer: Metabolic reprogramming in cancer cells profoundly impacts the responsiveness of these cells to drugs. Cancer cells rewire the flux of the metabolism of the three major nutrients, glucose, lipid, and amino acids, leading to abnormalities in drug orientation, defects in cell death mechanisms,
Yunhan Zhu, Weijie Yan, Lingfeng Tong, Jie Yang, Shengfang Ge, Jiayan Fan, Renbing Jia, Xuyang Wen   +7 more
wiley   +1 more source

Isolation and functional characterization of cold-regulated promoters, by digitally identifying peach fruit cold-induced genes from a large EST dataset [PDF]

, 2009
Background Cold acclimation is the process by which plants adapt to the low, non freezing temperatures that naturally occur during late autumn or early winter. This process enables the plants to resist the freezing temperatures of winter.
Andrés Tittarelli, Margarita Santiago, Andrea Morales, Lee A Meisel, Herman Silva   +4 more
core   +1 more source

Colorectal Cancer Cells Promote de novo Glycine Synthesis for Collagen Production in Cancer‐Associated Fibroblasts by Secreting TGF‐β1

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Cancer‐associated fibroblasts (CAFs) exhibit profound amino acid reprogramming, especially the production of glycine in colorectal cancer (CRC). CRC cell‐derived TGF‐β1 activates de novo glycine synthesis in CAFs, promoting collagen production. The pharmacological inhibition of PHGDH, the rate‐limiting enzyme of de novo glycine synthesis pathway ...
Chunqi Liu, Huaqin Zhang, Jin Gong, Yuzhou Xiao, Yiyun Lin, Wen Peng, Xiaodan Pan, Yan Li, Hui Jie, Xinying Qian, Na Sang, Lei Tao, Na Su, Jing Wei, Xiaobo Cen, Xiao Du, Yinglan Zhao   +16 more
wiley   +1 more source

Environmental Perturbations Lift the Degeneracy of the Genetic Code to Regulate Protein Levels in Bacteria [PDF]

, 2014
The genetic code underlying protein synthesis is a canonical example of a degenerate biological system. Degeneracies in physical and biological systems can be lifted by external perturbations, thus allowing degenerate systems to exhibit a wide range of ...
Cluzel, Philippe, Pan, Tao, Subramaniam, Arvind R   +2 more
core   +1 more source

Mitochondria ATP Pro‐Ferroptosis by Adjusting the Conversion of PUFA to PUFA‐PLs

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Glutamine deprivation can promote PUFA oxidation and PTGS2 expression through the upregulation of intracellular ROS, but not ferroptosis. Because glutamine deficiency exhausts mitochondrial ATP, thereby hinders the conversion of PUFA into their active form of PUFA‐CoA needed for lipid synthesis.
Chaoyi Xia, Lianchao Gao, Jingshu Min, Caiyun Fu   +3 more
wiley   +1 more source

eIF1 modulates the recognition of suboptimal translation initiation sites and steers gene expression via uORFs [PDF]

, 2017
Alternative translation initiation mechanisms such as leaky scanning and reinitiation potentiate the polycistronic nature of human transcripts. By allowing for reprogrammed translation, these mechanisms can mediate biological responses to stimuli.
Fijalkowska, Daria, Jonckheere, Veronique, Menschaert, Gerben, Ndah, Elvis, Van Damme, Petra, Verbruggen, Steven   +5 more
core   +1 more source

Genome-scale metabolic network reconstruction and in silico flux analysis of the thermophilic bacterium Thermus thermophilus HB27 [PDF]

, 2014
10.1186/1475-2859-13-61Microbial Cell Factories131 ...
Aggarwal, S., Karimi, I.A., Lakshmanan, M., Lee, D.-Y., Lee, N.-R., Park, J.-B., Song, J.-W.   +6 more
core   +2 more sources

Effect of adeno-associated virus (AAV)-mediated overexpression of PEPCK-M (Pck2) on Clenbuterol-induced muscle growth.

PLoS ONE, 2019
We previously identified PEPCK-M (encoded by the Pck2 gene) to be highly up-regulated in skeletal muscle of pigs treated with Ractopamine, an anabolic beta-adrenergic receptor agonist.
David M Loczenski-Brown, Sarah Jones, Jeni Luckett, Zoe Daniel, Madelaine C Brearley, Francis J P Ebling, Tim Parr, John M Brameld   +7 more
doaj   +1 more source

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth [PDF]

, 2016
We aimed to identify novel molecular mechanisms for muscle growth during administration of anabolic agents. Growing pigs (Duroc/(Landrace/Large-White)) were administered Ractopamine (a beta-adrenergic agonist; BA; 20ppm in feed) or Reporcin (recombinant ...
A Bassols, A Conesa, A Méndez-Lucas, AA Sneddon, AM Gunawan, B Sève, C Chaosap, C Kung, CP Velloso, DM Brown, DM Spurlock, EE Vincent, FA Wilson, FFS Depreux, FR Dunshea, GM DeNicola, GS Lynch, H Rhinn, J Bush, J Yang, J Ye, JA Bush, JA Higgins, JK Apple, JM Brameld, JW Locasale, JW Locasale, K Leithner, KM Hemmings, L Norton, L Sun, M Ruusunen, M Sandri, M Vestergaard, MA Pearen, MT Sørensen, O Bohorov, PJ Buttery, PJ Reeds, PM Tedeschi, PS Ward, PW Emery, R Koopman, R Possemato, RG Campbell, RJ DeBerardinis, RJ Samms, S Bardocz, S Modaressi, SA Gahr, SC Kalhan, SY Lunt, T Kitaura, T Laeger, T Parr, TA Armstrong, TJ Caperna, WO Kline, YR Boisclair   +58 more
core   +3 more sources

Molecular Marker-Assisted Selection of Rice Grain Quality on Rice (Oryza Sativa L.) Lines Tolerant to Fe Toxicity Stress [PDF]

, 2017
The elite rice has been produced, including iron (Fe) tolerant varieties. To get the appropriate rice lines which superior not only Fe tolerant but also have good grain quality needs to be developed selection system, especially in the use of molecular ...
Lestari, P. (Puji), Rosdianti, I. (Ida), Utami, D. W. (Dwinita), Utami, S. (Silvia), Widyastuti, U. (Utut)   +4 more
core   +2 more sources