APH Inhibitors that Reverse Aminoglycoside Resistance in Enterococcus casseliflavus. [PDF]
ChemMedChemMolecular dynamics simulations and in silico screening were used to identify non‐competitive inhibitors of APH, the enzymes that confer resistance to aminoglycoside antibiotics. A hit molecule showed activity against APH(2′′)‐IVa. Allosteric inhibition by the hit molecule and a two‐fold more potent analogue was confirmed by enzymatic measurements. Both
Kaplan E +6 more
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iMeta, Volume 1, Issue 4, December 2022., 2022 The diversity, composition, and network of gut microbiota differed between the sympatric and diet‐sharing Drosophila simulans and Dicranocephalus wallichii bowringi. Host species shape the bacterial and fungal community in two insect hosts by altering the relative contribution of community assembly processes.
Yu‐Xi Zhu +8 more
wiley +1 more source
Phosphoenolpyruvate:carbohydrate phosphotransferase system of bacteria. [PDF]
Microbiological Reviews, 1985 P.W. Postma, J W Lengeler
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Pantothenate Kinase Associated Neurodegeneration in Two Brothers
Acta Médica Portuguesa, 2015 Keywords: Neurodegenerative Diseases; Phosphotransferases (Alcohol Group Acceptor); Siblings.
Bruno Niemeyer de Freitas Ribeiro +3 more
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Effects of precursors on kitasamycin production in Streptomyces kitasatoensis
Bioscience Journal, 2019 To improve kitasamycin biosynthesis by Streptomyces kitasatoensis Z-7, the addition of two precursors, sodium acetate and ethyl acetate, to the fermentation medium was evaluated.
Xiong Zheng +4 more
doaj +3 more sources
Identification of a protein kinase activity that phosphorylates connexin43 in a pH-dependent manner
Brazilian Journal of Medical and Biological Research, 2000 The carboxyl-terminal (CT) domain of connexin43 (Cx43) has been implicated in both hormonal and pH-dependent gating of the gap junction channel. An in vitro assay was utilized to determine whether the acidification of cell extracts results in the ...
P. Yahuaca +4 more
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Protein Model and Function Analysis in Quorum-Sensing Pathway of Vibrio qinghaiensis sp.-Q67
Biology, 2021 Bioluminescent bacteria are mainly found in marine habitats. Vibrio qinghaiensis sp.-Q67 (Q67), a nonpathogenic freshwater bacterium, has been a focus due to its wide use in the monitoring of environmental pollution and the assessment of toxicity ...
Ze-Jun Wang +4 more
doaj +1 more source
Aminoglycoside 3'-phosphotransferase III, a new phosphotransferase. Resistance mechanism.
The Journal of Antibiotics, 1975 The aminoglycoside phosphotransferase of Pseudomonas aeruginosa 21-75 was purified by affinity chromatography using dibekacin-Sephadex 4B or lividomycin A-Sepharose 4B followed by DEAE Sephadex A-50 chromatography. It had activities of both the known aminoglycoside 3'-phosphotransferases I and II, and transferred phosphate from ATP to the 3'-hydroxyl ...
Tsutomu Sawa +6 more
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The unphosphorylated EIIA(Ntr) protein represses the synthesis of alkylresorcinols in Azotobacter vinelandii. [PDF]
PLoS ONE, 2015 Upon encystment induction, Azotobacter vinelandii produces the phenolic lipids alkylresorcinols (ARs) that are structural components of the cysts. The enzymes responsible for the ARs synthesis are encoded in the arsABCD operon, whose expression is ...
Luis Felipe Muriel-Millán +6 more
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Look and Outlook on Enzyme-Mediated Macrolide Resistance
Frontiers in Microbiology, 2018 Since their discovery in the early 1950s, macrolide antibiotics have been used in both agriculture and medicine. Specifically, macrolides such as erythromycin and azithromycin have found use as substitutes for β-lactam antibiotics in patients with ...
Tolou Golkar +3 more
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