Results 11 to 20 of about 25,251 (292)

PHOSPHOMANNOMUTASE 2-CONGENITAL DISORDER OF GLYCOSYLATION: A CASE REPORT AND LITERATURE REVIE [PDF]

open access: yes精准医学杂志, 2023
Objective To investigate the clinical and genetic features of patients with phosphomannomutase 2 (PMM2)-congenital disorder of glycosylation (CDG), and to provide a basis for the early diagnosis of PMM2-CDG. Methods A retrospective analysis was performed
WMENG Qiutong, ZHANG Tian, RAN Ni, YANG Zhaochuan, FU Peng, SHAN Yanchun
doaj   +1 more source

Merestinib monotherapy or in combination for japanese patients with advanced and/or metastatic cancer: A phase 1 study

open access: yesCancer Medicine, 2021
This phase 1, multi‐center, nonrandomized, open‐label, dose‐escalation study consisted of Part A wherein merestinib 80 or 120 mg (40‐mg tablets) was administered orally QD during a 28‐day cycle to patients diagnosed with solid tumors and Part B wherein ...
Toshihiko Doi   +9 more
doaj   +1 more source

Chromogenic Detection of Aminoglycoside Phosphotransferases [PDF]

open access: yesAntimicrobial Agents and Chemotherapy, 1998
ABSTRACT A coupled chromogenic reaction (based on an agar overlay combining NADH, pyruvate kinase, lactate dehydrogenase, phosphoenolpyruvate, ATP, and kanamycin sulfate with thiazolyl blue-phenazine methosulfate for detection of NADH consumption) was optimized for the detection of aminoglycoside phosphotransferases (APHs).
Ana Maria Amoroso   +1 more
openaire   +5 more sources

Global epigenetic changes induced by SWI2/SNF2 inhibitors characterize neomycin-resistant mammalian cells. [PDF]

open access: yesPLoS ONE, 2012
Previously, we showed that aminoglycoside phosphotransferases catalyze the formation of a specific inhibitor of the SWI2/SNF2 proteins. Aminoglycoside phosphotransferases, for example neomycin-resistant genes, are used extensively as selection markers in
Popy Dutta   +7 more
doaj   +1 more source

Pantothenate Kinase Associated Neurodegeneration in Two Brothers

open access: yesActa Médica Portuguesa, 2015
Keywords: Neurodegenerative Diseases; Phosphotransferases (Alcohol Group Acceptor); Siblings.
Bruno Niemeyer de Freitas Ribeiro   +3 more
doaj   +1 more source

In Silico Assigned Resistance Genes Confer Bifidobacterium with Partial Resistance to Aminoglycosides but Not to Β-Lactams [PDF]

open access: yes, 2013
peer-reviewedBifidobacteria have received significant attention due to their contribution to human gut health and the use of specific strains as probiotics.
Cotter, Paul D.   +6 more
core   +3 more sources

Effects of precursors on kitasamycin production in Streptomyces kitasatoensis

open access: yesBioscience Journal, 2019
To improve kitasamycin biosynthesis by Streptomyces kitasatoensis Z-7, the addition of two precursors, sodium acetate and ethyl acetate, to the fermentation medium was evaluated.
Xiong Zheng   +4 more
doaj   +3 more sources

Identification of a protein kinase activity that phosphorylates connexin43 in a pH-dependent manner

open access: yesBrazilian Journal of Medical and Biological Research, 2000
The carboxyl-terminal (CT) domain of connexin43 (Cx43) has been implicated in both hormonal and pH-dependent gating of the gap junction channel. An in vitro assay was utilized to determine whether the acidification of cell extracts results in the ...
P. Yahuaca   +4 more
doaj   +1 more source

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