Results 1 to 10 of about 4,150 (110)

APH Inhibitors that Reverse Aminoglycoside Resistance in Enterococcus casseliflavus. [PDF]

ChemMedChem
Molecular dynamics simulations and in silico screening were used to identify non‐competitive inhibitors of APH, the enzymes that confer resistance to aminoglycoside antibiotics. A hit molecule showed activity against APH(2′′)‐IVa. Allosteric inhibition by the hit molecule and a two‐fold more potent analogue was confirmed by enzymatic measurements. Both
Kaplan E, Chaloin L, Guichou JF, Berrou K, Rahimova R, Labesse G, Lionne C.   +6 more
europepmc   +2 more sources

Transition transferases prime bacterial capsule polymerization. [PDF]

Nat Chem Biol
Capsules are long-chain carbohydrate polymers that envelop the surfaces of many bacteria, protecting them from host immune responses. Capsule biosynthesis enzymes are potential drug targets and valuable biotechnological tools for generating vaccine ...
Litschko C, Di Domenico V, Schulze J, Li S, Ovchinnikova OG, Voskuilen T, Bethe A, Cifuente JO, Marina A, Budde I, Mast TA, Sulewska M, Berger M, Buettner FFR, Lowary TL, Whitfield C, Codée JDC, Schubert M, Guerin ME, Fiebig T.   +19 more
europepmc   +7 more sources

6-O-Nucleotidyltransferase: an aminoglycoside-modifying enzyme specific for streptomycin/streptidine [PDF]

, 2016
Aminoglycosides are especially useful for the treatment of hospital-acquired infections. The main problem for the application of these antibiotics is the presence of bacterial resistance enzymes, in particular, nucleotidyltransferases (ANTs).
Bastida, Agatha, García-Junceda, Eduardo, Latorre, Montserrat, Revuelta, Julia   +3 more
core   +1 more source

Nucleotide Sugars in Chemistry and Biology [PDF]

, 2022
Nucleotide sugars have essential roles in every living creature. They are the building blocks of the biosynthesis of carbohydrates and their conjugates.
Satu Mikkola
core   +1 more source

Enzymes Are Enriched in Bacterial Essential Genes [PDF]

, 2011
Essential genes, those indispensable for the survival of an organism, play a key role in the emerging field, synthetic biology. Characterization of functions encoded by essential genes not only has important practical implications, such as in identifying
AG Holman, AM Gustafson, AR Mushegian, BJ Akerley, C Lartigue, CM Sassetti, CT French, E Pennisi, EC Webb, EP Rocha, EV Koonin, Feng Gao, GC Langridge, H Jeong, IK Jordan, IM Keseler, J Deng, J Henkel, JI Glass, K Knuth, K Kobayashi, KSJY Ko, LA Gallagher, M Ashburner, M Kanehisa, M May, M Seringhaus, NM de S Cameron, NR Salama, NT Liberati, R Zhang, R Zhang, RA Forsyth, Randy Ren Zhang, RR Chaudhuri, S Gerdes, S Gotz, S Kumar, S Saha, SY Gerdes, T Baba, V de Berardinis, Vasu D. Appanna, W Huang da, Y Chen, Y Ji   +45 more
core   +4 more sources

Molecular fingerprints for a novel enzyme family in actinobacteria with glucosamine kinase activity [PDF]

, 2019
Actinobacteria have long been the main source of antibiotics, secondary metabolites with tightly controlled biosynthesis by environmental and physiological factors.
Empadinhas, N, Macedo-Ribeiro, S, Manso, JA, Nunes-Costa, D, Pereira, PJB   +4 more
core   +1 more source

AglH, a thermophilic UDP‑N‑acetylglucosamine‑1‑phosphate:dolichyl phosphate GlcNAc‑1‑phosphotransferase initiating protein N‑glycosylation pathway in Sulfolobus acidocaldarius, is capable of complementing the eukaryal Alg7 [PDF]

, 2016
AglH, a predicted UDP-GlcNAc-1-phosphate:dolichyl phosphate GlcNAc-1-phosphotransferase, is initiating the protein N-glycosylation pathway in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius. AglH successfully replaced the endogenous GlcNAc-1-
A Bouhss, A Larkin, A Larkin, A Spang, A Typas, AJ Lloyd, AO Amer, AO Amer, AR Nogare Dal, B Chaban, B Chaban, Benjamin H. Meyer, BH Meyer, BH Meyer, BH Meyer, C Ginsberg, C Whitfield, C Yanisch-Perron, D Calo, D Calo, D Mumberg, DC Alexander, DJ Mancuso, DW Grogan, E Hartmann, FA Troy, G Paul, G Samuel, G Schmidt, H Shams-Eldin, Hosam Shams-Eldin, J Jaeken, J Lehrer, J Lu, JD Esko, JM Archibald, K Hjort, KF Jarrell, KJ Glover, KJ Stone, KR Mclachlan, L Guy, L Kaminski, L Masson, L Xu, M Wagner, M Wagner, MA Lehrman, MG Elferink, MM Chang, MS Anderson, N Kurosawa, O Wurtzel, P Burda, PA Amor, R Mazhari-Tabrizi, RS Sikorski, S Brown, S Ohnuma, S Ohnuma, S Yamashita, S Yurist-Doutsch, Sonja-Verena Albers, TD Brock, TD Bugg, U Meier-Dieter, U Zahringer, V Eckert, W Meyer, Y Boucher, Y Taguchi, Z Guan, Z Guan, ZQ Guan   +73 more
core   +2 more sources

Singular Features of Trypanosomatids' Phosphotransferases Involved in Cell Energy Management [PDF]

, 2011
Trypanosomatids are responsible for economically important veterinary affections and severe human diseases. In Africa, Trypanosoma brucei causes sleeping sickness or African trypanosomiasis, while in America, Trypanosoma cruzi is the etiological agent of
Bouvier, León A., Cámara, María de los Milagros, Miranda, Mariana R., Pereira, Claudio A.   +3 more
core   +4 more sources

Catalytic mechanism of the colistin resistance protein MCR-1 [PDF]

, 2020
The mcr-1 gene encodes a membrane-bound Zn2+-metalloenzyme, MCR-1, which catalyses phosphoethanolamine transfer onto bacterial lipid A, making bacteria resistant to colistin, a last-resort antibiotic.
Fey, Natalie, Hinchliffe, Philip, Lythell, Emily, Mulholland, Adrian J, Spencer, James, Suardíaz, Reynier, Van Der Kamp, Marc W   +6 more
core   +1 more source

Phosphorylation Mechanism of Phosphomevalonate Kinase: Implications for Rational Engineering of Isoprenoid Biosynthetic Pathway Enzymes [PDF]

, 2016
The mevalonate pathway is of important clinical, pharmaceutical, and biotechnological relevance. However, lack of the understanding of the phosphorylation mechanism of the kinases in this pathway has limited rationally engineering the kinases in industry.
Hu, Guixiiang, Huang, Meilan, Li, Xiao, McClory, James, Timson, David J., Wei, Kexin, Zou, Jian-Wei   +6 more
core   +4 more sources