Results 21 to 30 of about 4,347 (134)

Enzymes Are Enriched in Bacterial Essential Genes [PDF]

, 2011
Essential genes, those indispensable for the survival of an organism, play a key role in the emerging field, synthetic biology. Characterization of functions encoded by essential genes not only has important practical implications, such as in identifying
AG Holman, AM Gustafson, AR Mushegian, BJ Akerley, C Lartigue, CM Sassetti, CT French, E Pennisi, EC Webb, EP Rocha, EV Koonin, Feng Gao, GC Langridge, H Jeong, IK Jordan, IM Keseler, J Deng, J Henkel, JI Glass, K Knuth, K Kobayashi, KSJY Ko, LA Gallagher, M Ashburner, M Kanehisa, M May, M Seringhaus, NM de S Cameron, NR Salama, NT Liberati, R Zhang, R Zhang, RA Forsyth, Randy Ren Zhang, RR Chaudhuri, S Gerdes, S Gotz, S Kumar, S Saha, SY Gerdes, T Baba, V de Berardinis, Vasu D. Appanna, W Huang da, Y Chen, Y Ji   +45 more
core   +4 more sources

Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress. [PDF]

, 2015
Adenylate kinases (AKs) are phosphotransferases that regulate the cellular adenine nucleotide composition and play a critical role in the energy homeostasis of all tissues.
Al-Zahrani, Alberto Rissone, Alex DeVine, Aloj, Antoine, Argenton, Axel Schambach, Bandlow, Bertrand, Bertrand, Bujan, Burkart, Castaigne, Chen, Choi, Craven, Daily, De Vaal, Dzeja, Dzeja, Dzeja, Elisa Giocaliere, Fabio Candotti, Finckbeiner, Fischer, Flicek, Fujisawa, Giancarlo la Marca, Goujon, Hatefi, Henderson, Jang, Janssen, Jayashree Jagadeesh, Karen Lyn Simon, Katja Gabriele Weinacht, Kerry Dobbs, Kerstin Felgentreff, Kevin Bishop, Kimmel, Kissa, Köhler, Lagresle-Peyrou, Lagresle-Peyrou, Lawson, Le Guyader, Lee, Lee, Liesa, Lin, Liu, Luigi D. Notarangelo, Martha Kirby, Marypat Jones, Mugoni, Pannicke, Park, Park, Poliani, Pucar, Pucar, Raman Sood, Renaud, Rissone, Ryter, Sauer, Settara Chandrasekharappa, Shapiro, Sheehan, Single, Sood, Sood, Stephen Wincovitch, Takubo, Thisse, Thorsten Schlaeger, Traver, Waleed Al-Herz, Warlich, Westerfield, Whitford, Yuval Itan   +81 more
core   +4 more sources

Singular Features of Trypanosomatids' Phosphotransferases Involved in Cell Energy Management [PDF]

, 2011
Trypanosomatids are responsible for economically important veterinary affections and severe human diseases. In Africa, Trypanosoma brucei causes sleeping sickness or African trypanosomiasis, while in America, Trypanosoma cruzi is the etiological agent of
Bouvier, León A., Cámara, María de los Milagros, Miranda, Mariana R., Pereira, Claudio A.   +3 more
core   +4 more sources

Lipid phosphate phosphatase 3 participates in transport carrier formation and protein trafficking in the early secretory pathway [PDF]

, 2013
The inhibition of phosphatidic acid phosphatase (PAP) activity by propanolol indicates that diacylglycerol (DAG) is required for the formation of transport carriers at the Golgi and for retrograde trafficking to the ER.
Alderton, Ambroggio, Antony, Asp, Bard, Baron, Bechler, Beck, Ben-Tekaya, Ben-Tekaya, Billah, Brindley, Brindley, Brown, Burger, Cabrera, Carrasco, de Figueiredo, Dejgaard, Escalante-Alcalde, Fernández-Ulibarri, Grigoriev, Grigoriev, Grimsey, Hammond, Henneberry, Ho, Huijbregts, Humtsoe, Jackson, Jasinska, Johannes, Kai, Kai, Kano, Kearns, Klumperman, Kooijman, Krauss, Lev, Lippincott-Schwartz, Litvak, Long, Long, Martinez, Martínez-Alonso, Meier, Morikawa, Morris, Mérida, Nagaya, Nilsson, Pappu, Pyne, Pyne, Roberts, Rohde, Roth, Roux, San Pietro, Saraste, Sarri, Schindler, Schmidt, Sciorra, Shemesh, Sigal, Sorre, Subathra, Tian, Ulrix, van Meer, Villani, Waggoner, White, Yang, Yang, Zhang   +77 more
core   +2 more sources

Catalytic mechanism of the colistin resistance protein MCR-1 [PDF]

, 2020
The mcr-1 gene encodes a membrane-bound Zn2+-metalloenzyme, MCR-1, which catalyses phosphoethanolamine transfer onto bacterial lipid A, making bacteria resistant to colistin, a last-resort antibiotic.
Fey, Natalie, Hinchliffe, Philip, Lythell, Emily, Mulholland, Adrian J, Spencer, James, Suardíaz, Reynier, Van Der Kamp, Marc W   +6 more
core   +2 more sources

Molecular mechanism of dietary phospholipid requirement of Atlantic salmon, Salmo salar, fry [PDF]

, 2015
The phospholipid (PL) requirement in fish is revealed by enhanced performance when larvae are provided PL-enriched diets. To elucidate the molecular mechanism underlying PL requirement in Atlantic salmon, Salmo salar, were fed a minimal PL diet and ...
Carmona-Antoñanzas, Greta, Martinez-Rubio, Laura, Taylor, John, Tocher, Douglas R   +3 more
core   +1 more source

Biochemical characterization of the maltokinase from Mycobacterium bovis BCG [PDF]

, 2010
Background Maltose-1-phosphate was detected in Mycobacterium bovis BCG extracts in the 1960's but a maltose-1-phosphate synthetase (maltokinase, Mak) was only much later purified from Actinoplanes missouriensis, allowing the identification of the mak ...
da Costa, Milton S, Empadinhas, Nuno, Lamosa, Pedro, Maranha, Ana, Mendes, Vítor   +4 more
core   +3 more sources

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Self-Resistance During Muraymycin Biosynthesis: A Complementary Nucleotidyltransferase and Phosphotransferase with Identical Modification Sites and Distinct Temporal Order [PDF]

, 2018
Muraymycins are antibacterial natural products from Streptomyces spp. that inhibit translocase I (MraY), which is involved in cell wall biosynthesis. Structurally, muraymycins consist of a 5′-C-glycyluridine (GlyU) appended to a 5″-amino-5″-deoxyribose ...
Cui, Zheng, Ducho, Christian, Koppermann, Stefan, Lemke, Anke, Liu, Xiaodong, Rohr, Jürgen, Thorson, Jon S., Van Lanen, Steven G., Wang, Xia-Chang   +8 more
core   +2 more sources

Conformational dynamics in insulin receptor kinase reveal a type III allosteric pocket

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Allosteric modulation is a promising strategy for selective kinase inhibition, yet structural insights into allosteric pockets remain limited across the human kinome. In this work, we present comprehensive characterization of a type III allosteric pocket in the insulin receptor kinase (IRK), integrating structural, conformational, and ...
Jyoti Verma, Harish Vashisth
wiley   +1 more source