Drug-Induced Photosensitivity: Clinical Types of Phototoxicity and Photoallergy and Pathogenetic Mechanisms [PDF]
Frontiers in Allergy, 2022 Drug-induced photosensitivity (DIP) is a common cutaneous adverse drug reaction, resulting from the interaction of ultraviolet radiations, mostly ultraviolet A, with drugs. DIP includes phototoxicity and photoallergy.
Luca Di Bartolomeo +10 more
doaj +5 more sources
Photoallergy to Naproxen. [PDF]
Cureus, 2021 Reactions caused by photosensitivity, also called photodermatosis, are cutaneous reactions induced or exacerbated by exposure to electromagnetic radiation, including UV radiation, visible light, and infrared radiation.
Rojas Perez-Ezquerra P +4 more
europepmc +8 more sources
Innovative Strategies for Photoallergy Assessment: Breaking Free from Animal Models in Cosmetic Ingredient Development [PDF]
CosmeticsPhotoallergy, a unique form of skin sensitization induced by specific compounds under ultraviolet irradiation, has traditionally been investigated using animals.
Adriana Solange Maddaleno +2 more
doaj +5 more sources
Pterin-lysine photoadduct: a potential candidate for photoallergy [PDF]
Photochemical & Photobiological Sciences, 2022 Photoallergy is a photosensitivity disorder associated with a modified ability of the skin to react to the combined effect of drugs and sunlight. It has been attributed to the covalent conjugation of proteins with a photosensitizer, yielding modified ...
Jesuán J. Farías +4 more
semanticscholar +11 more sources
Topical minocycline foam 4%: Results of four phase 1 studies evaluating the potential for phototoxicity, photoallergy, sensitization, and cumulative irritation [PDF]
Journal of Immunotoxicology, 2019 FMX101 4% contains 4% micronized minocycline (as an HCl) formulated in a lipophilic foam vehicle for topical administration. FMX101 4% has been shown to be an effective and well-tolerated treatment for moderate-to-severe acne in three Phase 3 pivotal ...
Jonathan Dosik +2 more
doaj +3 more sources
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2015 SummaryMany – topically applied or systemically administered – substances may trigger photoallergic skin reactions following exposure to ultraviolet (UV) radiation. While most cases represent photoallergic contact dermatitis due to topically applied agents, systemically triggered photoallergy is considerably less common.
Anna Wilm, Mark Berneburg
semanticscholar +5 more sources
Latest Evidence Regarding the Effects of Photosensitive Drugs on the Skin: Pathogenetic Mechanisms and Clinical Manifestations [PDF]
Pharmaceutics, 2020 Photosensitivity induced by drugs is a widely experienced problem, concerning both molecule design and clinical practice. Indeed, photo-induced cutaneous eruptions represent one of the most common drug adverse events and are frequently an important issue
Flavia Lozzi +10 more
doaj +5 more sources
Experimental Photoallergy to Systemic Drugs
Journal of Investigative Dermatology, 1985 We have induced photoallergy in mice to systemically administered drugs, specifically sulfanilamide and chlorpromazine. Mice were photosensitized to systemic sulfanilamide or chlorpromazine by i.p.
Paula A. Giudici, Henry Maguire
semanticscholar +5 more sources
Establishment of an in vitro photoallergy test using NCTC2544 cells and IL-18 production [PDF]
Toxicology in Vitro, 2012 Differentiation between photoallergenic and phototoxic reactions induced by low molecular weight compounds represents a current problem. The use of eratinocytes as a potential tool for the detection of photoallergens as opposed to photoirritants is ...
Valentina Galbiati +4 more
semanticscholar +4 more sources
Contact Sensitization and Phototoxic and Photoallergic Potential of Tirbanibulin 1% Ointment in Healthy Volunteers [PDF]
JID Innovations, 2023 Tirbanibulin 1% ointment is approved for the topical treatment of actinic keratosis, applied once daily for 5 days. Three phase 1 randomized, single-center, controlled, within-subject comparison studies were conducted to evaluate the sensitization (KX01 ...
Jonathan Dosik +3 more
doaj +2 more sources