Drug-Induced Photosensitivity—From Light and Chemistry to Biological Reactions and Clinical Symptoms [PDF]
Pharmaceuticals, 2021 Photosensitivity is one of the most common cutaneous adverse drug reactions. There are two types of drug-induced photosensitivity: photoallergy and phototoxicity. Currently, the number of photosensitization cases is constantly increasing due to excessive
Justyna Kowalska +3 more
doaj +2 more sources
Japanese Journal of Clinical Immunology, 2011 Photoallergy is an entity of allergy in the dermatological field. Sunlight is involved in the pathophysiology of photoallergy. Photoallergy is classified into intrinsic and extrinsic diseases. As extrinsic diseases, photosensitivity due to drugs and photocontact dermatitis are important for physicians as well as dermatologists.
Akira Kawada
openalex +4 more sources
Modernizing U.S. Sunscreen Regulations: How Newer Filters Can Improve Public Health. [PDF]
Photodermatol Photoimmunol PhotomedABSTRACT Background Skin cancer is the most common cancer in the United States, with over 5 million cases diagnosed annually. Despite being largely preventable, incidence rates continue to rise, largely due to inadequate protection from ultraviolet (UV) radiation, the primary environmental cause of skin cancer.
Turner CW, Torgerson L.
europepmc +2 more sources
Photosensitivity to Triflusal: Formation of a Photoadduct with Ubiquitin Demonstrated by Photophysical and Proteomic Techniques [PDF]
Frontiers in Pharmacology, 2016 Triflusal is a platelet aggregation inhibitor chemically related to acetylsalicylic acid, which is used for the prevention and/or treatment of vascular thromboembolisms, which acts as a prodrug.
E Nuin +4 more
doaj +5 more sources
Probing skin photoallergens in reconstructed human epidermis: An EPR spin trapping investigation. [PDF]
Photochem PhotobiolWe present an original proof‐of‐concept methodology to probe radical generation from allergens in contact with photoexposed skin, using electron paramagnetic resonance and spin trapping in a reconstructed human epidermis model mimicking real‐life exposure scenarios.
Port-Lougarre Y +3 more
europepmc +2 more sources
PhotoChem Reference Chemical Database for the Development of New Alternative Photosafety Test Methods [PDF]
ToxicsPhotosafety assessments are a key requirement for the safe development of pharmaceuticals, cosmetics, and agrochemicals. Although in vitro methods are widely used for phototoxicity and photoallergy testing, their limited applicability and predictive ...
Ga-Young Lee +4 more
doaj +2 more sources
Photosensitivity Reactions Induced by Photochemical Degradation of Drugs [PDF]
Advanced Pharmaceutical Bulletin, 2022 Photochemical degradation of drugs can lead to degradation products with potential toxic or allergizing effects for the human body. A significant amount of work has been carried out over the past few decades to clarify the molecular mechanism of ...
Hajnal Klelemen +3 more
doaj +2 more sources
, 2018 Drugs are one of the representative exogenous agents that cause photosensitive dermatitis. Both phototoxic and photoallergic mechanisms exist in photosensitivity to exogenous agents.
Y. Tokura
openalex +2 more sources
Formation of Antigenic Quinolone Photoadducts on Langerhans Cells Initiates Photoallergy to Systemically Administered Quinolone in Mice [PDF]
Journal of Investigative Dermatology, 2000 Quinolone antibacterial agents are well known to cause photoallergy as a side-effect. Murine photoallergy to fluoroquinolones is a T cell-mediated immune response, evoked either by systemic fluoroquinolone and subsequent exposure of skin to ultraviolet A
Akihiro Ohshima +3 more
openalex +2 more sources
Long-Term Observations on the European Photopatch Test Baseline Series (EPTBS) in Real Clinical Practice: 11 Years of Results in a Spanish Cohort and Suggestions for an EPTBS Update. [PDF]
Contact DermatitisABSTRACT Background The European Photopatch Testing Baseline Series (EPTBS) was published in 2013. However, limited data exist regarding the real‐world clinical application of the EPTBS. Objectives This study aims to describe the photopatch test experience with the EPTBS over 11 years at a tertiary hospital in Spain.
Gómez-Martínez S +4 more
europepmc +2 more sources