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Photosensitizers for Photodynamic Therapy
Advanced Healthcare Materials, 2019AbstractAs an emerging clinical modality for cancer treatment, photodynamic therapy (PDT) takes advantage of the cytotoxic activity of reactive oxygen species (ROS) that are generated by light irradiating photosensitizers (PSs) in the presence of oxygen (O2).
Minhuan Lan +5 more
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Photodynamic Therapy in Gynecology
Obstetrics and Gynecology Clinics of North America, 1991PDT is a technique in which visible light is used in combination with photosensitizing agents to achieve a tumoricidal effect. Hematoporphyrins are the most commonly used photosensitizers in clinical practice. DHE is the active fraction of hematoporphyrin. Intravenously injected DHE is found in highest concentration in the liver followed by the spleen,
M, Spitzer, B A, Krumholz
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Photodynamic Therapy in Dermatology
Archives of Dermatology, 1998Photodynamic therapy (PDT) uses exogenously administered or endogenously formed photosensitizers activated by light to induce cell death via formation of singlet oxygen and other free radicals. Photodynamic therapy is increasingly used for the treatment of skin cancers and other indications.
C, Fritsch, G, Goerz, T, Ruzicka
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Photodynamic therapy in dermatology
Journal of the American Academy of Dermatology, 2000The combination of light and chemicals to treat skin diseases is widely practiced in dermatology. Within this broad use of light and drugs, in recent years the concept of photodynamic therapy (PDT) has emerged. PDT is a promising modality for the management of various tumors and nonmalignant diseases, based on the combination of a photosensitizer that ...
K, Kalka, H, Merk, H, Mukhtar
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Dermatology, 2007
<i>Background:</i> Photodynamic therapy (PDT) is increasingly used in the treatment of various skin diseases. The main adverse effect in PDT treatment is pain. Each lesion is generally treated twice, and clinical experience suggests that the 2nd treatment causes more pain than the 1st and thus becomes a therapy-limiting factor.
Katrine E K, Lindeburg +2 more
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<i>Background:</i> Photodynamic therapy (PDT) is increasingly used in the treatment of various skin diseases. The main adverse effect in PDT treatment is pain. Each lesion is generally treated twice, and clinical experience suggests that the 2nd treatment causes more pain than the 1st and thus becomes a therapy-limiting factor.
Katrine E K, Lindeburg +2 more
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Photodynamic therapy in oncology
Expert Opinion on Pharmacotherapy, 2001Photodynamic therapy (PDT) is a cancer treatment modality that is based on the administration of a photosensitiser, which is retained in tumour tissues more than in normal tissues, followed by illumination of the tumour with visible light in a wavelength range matching the absorption spectrum of the photosensitiser.
C H, Sibata +3 more
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Photodynamic therapy: An update
Clinical Oncology, 1994The cytotoxic potential of photosensitisers has been known for more than half a century, but it is only in the last decade or so that it has been studied in much greater depth and evaluated critically in both laboratory and clinical settings. Photodynamic therapy (PDT) usually involves the systemic administration of a photosensitiser which is retained ...
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Photodynamic therapy for mesothelioma
Current Treatment Options in Oncology, 2001Multiple trials of traditional cancer therapies for malignant pleural mesothelioma (including surgery, radiation therapy, and chemotherapy) have not convincingly demonstrated that any one treatment is superior to supportive care alone. Although there have been reports of long-term survivors who were treated with aggressive surgery combined with ...
S M, Hahn, R P, Smith, J, Friedberg
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Lasers in Surgery and Medicine, 2006
AbstractBackground and ObjectivesPhotodynamic therapy (PDT) is an emerging modality for the treatment of various neoplastic and non‐neoplastic pathologies.Study Design/Materials and MethodsPDT usually occurs when reactive oxygen species (ROS) generated from light‐activated chemicals (photosensitizer, PS) destroy the target.
Nicolas, Solban +2 more
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AbstractBackground and ObjectivesPhotodynamic therapy (PDT) is an emerging modality for the treatment of various neoplastic and non‐neoplastic pathologies.Study Design/Materials and MethodsPDT usually occurs when reactive oxygen species (ROS) generated from light‐activated chemicals (photosensitizer, PS) destroy the target.
Nicolas, Solban +2 more
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2019
Photodynamic therapy is a promising, minimally invasive, and clinically approved treatment strategy that destroys the cell components by oxidizing the biological molecules such as nucleic acids, carbohydrates, proteins, and lipids, and leads apoptosis in the cells of the target tissue through the generation of singlet oxygen and reactive oxygen species
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Photodynamic therapy is a promising, minimally invasive, and clinically approved treatment strategy that destroys the cell components by oxidizing the biological molecules such as nucleic acids, carbohydrates, proteins, and lipids, and leads apoptosis in the cells of the target tissue through the generation of singlet oxygen and reactive oxygen species
openaire +3 more sources