Results 171 to 180 of about 1,927 (190)
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Photopharmacological control of lipid function
2020Photopharmacology enables the optical control of biological processes through the use of molecular photoswitches, such as functionalized azobenzenes. In this protocol, we describe general considerations for working with bioactive azobenzene photoswitches. Our approach is exemplified with a photoswitchable sphingosine-1-phosphate analog (PhotoS1P).
Johannes, Morstein, Dirk, Trauner
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Specificity and Speed: Tethered Photopharmacology
Biochemistry, 2017Genetics and pharmacology are often seen as two distinct approaches to interrogating, elucidating, and manipulating biological systems. The former is renowned for its precision whereas the latter for its fast kinetics, reversibility, and practicality.
Philipp Leippe +2 more
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A Roadmap to Success in Photopharmacology
Accounts of Chemical Research, 2015Light is a fascinating phenomenon that ties together physics, chemistry, and biology. It is unmatched in its ability to confer information with temporal and spatial precision and has been used to map objects on the scale of tens of nanometers (10(-8) m) to light years (10(16) m).
Johannes, Broichhagen +2 more
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Photopharmacology in Alzheimer's Disease
Advanced Therapeutics, 2018AbstractIn this report, the advances of photopharmacology as a method that allows the study of therapeutically relevant target proteins for Alzheimer's disease (AD) with high spatiotemporal resolution through photoswitchable molecules that are manipulated by light irradiation will be presented.
Diego Alejandro Rodríguez‐Soacha +1 more
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Photopharmacological approaches for dissecting potassium channel physiology
Current Opinion in Pharmacology, 2022Photopharmacology allows for the remote control of ion channels and receptors by the application of light-sensitive compounds. Upon irradiation with light these molecules change their configuration, enabling channel modulation with both spatial and temporal resolution.
Stephanie Häfner, Guillaume Sandoz
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Photopharmacological control of cell signaling with photoswitchable lipids
Current Opinion in Pharmacology, 2022Many aspects of cell signaling are controlled by lipids. Several signaling lipids have been functionalized with an azobenzene photoswitch to control underlying signaling dynamics with light. Herein, we provide an overview of signaling photolipids developed to date focusing on their biological applications.
Tufan K, Mukhopadhyay +2 more
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New challenges for photopharmacology and computational modeling
Trends in Biochemical Sciences, 2022Mous et al. recently reported the molecular mechanism of chloride transport through a light-activated pumping rhodopsin, a key process involved in a range of cellular functions. Their results open exciting new challenges for photopharmacology and computational modeling that should be addressed in the coming years.
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Optofluidic neural interfaces for in vivo photopharmacology
Current Opinion in Pharmacology, 2022Light-sensitive small molecules can be applied to control cell signaling with enhanced spatiotemporal precision, and their accuracy in intact tissues like the brain can be further enhanced by tethering them to genetically encoded protein tags. Coined "photopharmacology," this approach can acutely manipulate neurotransmission through specific receptor ...
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ChemInform Abstract: Emerging Targets in Photopharmacology
ChemInform, 2016AbstractReview: 184 refs.
Michael M. Lerch +4 more
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In vivo adrenergic modulation with photopharmacology
2021Adrenoceptors are ubiquitous and regulate most vital functions in the human body, including heart and respiratory rate, digestion, smooth-muscle contraction, gland secretion, and pupil diameter among others. In addition, adrenergic neurons firing from the locus coeruleus towards different areas of the central nervous system mediate alertness, responses
D. Prischich +14 more
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