Results 161 to 170 of about 2,002 (201)

Synthesis of <i>N</i>-acetyl diazocine derivatives via cross-coupling reaction. [PDF]

Beilstein J Org Chem
Brandt T, Lentes P, Rudtke J, Hösgen M, Näther C, Herges R.   +5 more
europepmc   +1 more source

Manipulation of Chemistry and Biology with Visible Light Using Tetra-ortho-Substituted Azobenzenes and Azonium Ions. [PDF]

Angew Chem Int Ed Engl
Cardano F, Márquez García R, Szymanski W.   +2 more
europepmc   +1 more source

A Transient Phenolate Enables Relaxation of Z-Tetra-ortho-fluoroazobenzene to the Stable State in Seconds. [PDF]

Angew Chem Int Ed Engl
Brittain W, Barrett S, Mouer L, Sauceda N.   +3 more
europepmc   +1 more source

Reversible Photoswitching of Donor-Acceptor Stenhouse Adducts in Water. [PDF]

J Am Chem Soc
Blandón-Cumbreras FG, Jurtík M, Závodná A, Janovský P, Rouchal M, Vícha R, Pischel U.   +6 more
europepmc   +1 more source

Light-Activatable, Cell-Type Specific Labeling of the Nascent Proteome. [PDF]

ACS Chem Neurosci
Evans HT, Ko T, Oliveira MM, Yu A, Kalavai SV, Golhan EN, Polavarapu A, Balamoti E, Wu V, Klann E, Trauner D.   +10 more
europepmc   +1 more source

Standardized and Quantitative ICG Perfusion Assessment: Feasibility and Reproducibility in a Multicentre Setting. [PDF]

Life (Basel)
Feitsma E, Schouw H, Hoffman T, van Dijk S, Heeman W, Vonk J, Tange F, Koetje J, Jansen L, Schepers A, van Ginhoven T, Kelder W, van Dam G, Szymanski W, Noltes M, Kruijff S.   +15 more
europepmc   +1 more source

Photopharmacology of Antimitotic Agents [PDF]

International Journal of Molecular Sciences, 2022
Antimitotic agents such as the clinically approved vinca alkaloids, taxanes and epothilone can arrest cell growth during interphase and are therefore among the most important drugs available for treating cancer. These agents suppress microtubule dynamics and thus interfere with intracellular transport, inhibit cell proliferation and promote cell death.
Susanne Kirchner, Zbigniew L Pianowski
exaly   +7 more sources

Rational Design in Photopharmacology with Molecular Photoswitches [PDF]

Angewandte Chemie - International Edition, 2023
AbstractPhotopharmacology is an attractive approach for achieving targeted drug action with the use of light. In photopharmacology, molecular photoswitches are introduced into the structure of biologically active small molecules to allow for the optical control of their potency.
Piermichele Kobauri, Frank J Dekker, Wiktor Szymanski   +2 more
exaly   +5 more sources

Emerging Targets in Photopharmacology [PDF]

Angewandte Chemie - International Edition, 2016
AbstractThe field of photopharmacology uses molecular photoswitches to establish control over the action of bioactive molecules. It aims to reduce systemic drug toxicity and the emergence of resistance, while achieving unprecedented precision in treatment. By using small molecules, photopharmacology provides a viable alternative to optogenetics.
Michael M Lerch, Mickel J Hansen, Gooitzen M Van Dam   +2 more
exaly   +4 more sources

GPCR photopharmacology

Molecular and Cellular Endocrinology, 2019
New technologies for spatial and temporal remote control of G protein-coupled receptors (GPCRs) are necessary to unravel the complexity of GPCR signalling in cells, tissues and living organisms. An effective approach, recently developed, consists on the design of light-operated ligands whereby light-dependent GPCR activity regulation can be achieved ...
Joan Font, Amadeu Llebaria
exaly   +4 more sources